Naproxen Plus Tablet

Uses of Naproxen Plus Tablet

• Pain Relief

How does Naproxen Plus Tablet work?

Naproxen Plus Tablet is a pain-relieving medication that contains a combination of two medicines: Naproxen and Esomeprazole. Naproxen is a non-steroidal anti-inflammatory drug (NSAID) that works by blocking the release of certain chemical messengers responsible for causing pain, fever, and inflammation (redness and swelling). Esomeprazole is a proton-pump inhibitor that reduces stomach acid levels, protecting the stomach lining from damage caused by Naproxen.

Side Effects of Naproxen Plus Tablet

• Headache
• Nausea
• Vomiting
• Diarrhea
• Indigestion
• Flatulence
• Stomach pain
• Flu-like symptoms

Quick Suggestions:

• Naproxen Plus Tablet is used to treat various painful conditions.
• Take it with a glass of milk in order to prevent side effects such as indigestion.
• If you have asthma, symptoms such as wheezing or breathlessness might get worse with Naproxen Plus Tablet. In such a case see your doctor right away.
• Inform your doctor if you have or ever had ulcers in your stomach or intestines.
• Inform your doctor if you are planning to have an operation (even a minor one, such as tooth extraction) since Naproxen Plus Tablet increases the risk of bleeding.

Indication of Naproxen Plus Tablet

Naproxen Plus Tablet contains Naproxen and esomeprazole (antacid). Naproxen is an anti-inflammatory and analgesic agent that reduces inflammation and relieves pain by blocking the COX enzyme responsible for producing pain-causing substances called prostaglandins. This reduces pain, swelling, and joint stiffness in various conditions, including fibrositis, tenosynovitis, low back pain, strains, and sprains.

Naproxen, like other NSAIDs, may cause gastric discomfort and increase the risk of stomach ulcers. To address this, it is combined with esomeprazole, a proton pump inhibitor that reduces stomach acid secretion. This combination helps minimize gastric irritation and ulceration risk, making it suitable for long-term treatment in individuals with pre-existing stomach ulcers or a history of developing stomach ulcers while using NSAIDs.

Pharmacology

Naproxen Plus Tablet consists of a fast-releasing Esomeprazole Magnesium coating and an enteric-coated Naproxen core. Esomeprazole is released in the stomach first, while Naproxen dissolves in the small intestine.

Naproxen is an NSAID with analgesic and antipyretic effects that work by blocking prostaglandin production. Esomeprazole is a proton pump inhibitor that inhibits gastric acid secretion by targeting the H+/K+ ATPase in gastric cells, leading to reduced gastric acidity. It selectively acts on the proton pump, blocking the final stage of acid generation.

Dosage & Administration of Naproxen Plus Tablet

Before using  Naproxen Plus Tablet, carefully consider the potential benefits and risks, as well as other treatment options. Use the lowest effective dose for the shortest duration that aligns with the individual patient's treatment goals. If a lower dose of Esomeprazole (less than 40 mg total daily dose) is more appropriate, consider alternative treatments.

Dosage for different conditions:

Rheumatoid Arthritis, Osteoarthritis, and Ankylosing Spondylitis in adults: Take one tablet twice daily of either 375 mg naproxen/20 mg of esomeprazole or 500 mg naproxen/20 mg of esomeprazole.

Juvenile Idiopathic Arthritis in Adolescent Patients 12 Years of Age and Older:

• Weight greater than 50 kg: Take one tablet twice daily of 375 mg naproxen/20 mg of esomeprazole or 500 mg naproxen/20 mg of esomeprazole.
• Weight 38 kg to less than 50 kg: Take one tablet twice daily of 375 mg naproxen/20 mg of esomeprazole.

Important instructions:

• Do not split, chew, crush, or dissolve the tablet.
• Take the tablet at least 30 minutes before meals.

Interaction

Naproxen Plus Tablet may interact with several drugs and should be used with caution in certain medical conditions:

Drug-Drug Interactions:

• Interaction with anti-inflammatory medicines (e.g. aspirin, ibuprofen)
• Interaction with blood thinners (e.g. warfarin, rivaroxaban)
• Interaction with steroids (e.g. prednisolone)
• Interaction with diuretic medicines (e.g. furosemide)
• Interaction with heart and high blood pressure-lowering medicines (e.g. propranolol, enalapril, losartan, candesartan)
• Interaction with antidepressants (e.g. citalopram)
• Interaction with medicine used to treat rheumatoid arthritis (e.g. methotrexate)

Drug-Food Interactions:

• Interaction with alcohol: Avoid alcohol intake while taking Naproxen Plus Tabletas it may increase the risk of stomach bleeding and cause drowsiness and dizziness.

Drug-Disease Interactions:

• People with diabetes, stomach ulcers, gastrointestinal bleeding, asthma, kidney, liver, or heart problems, and autoimmune conditions like systemic lupus erythematosus, colitis, or Crohn’s disease should consult a doctor before taking Naproxen Plus Tablet.

Contraindications

Naproxen Plus Tablet is contraindicated in the following situations:

• Hypersensitivity to any of the ingredients of the product.
• Patients who have developed asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
• Treatment of intraoperative pain during coronary artery bypass grafting (CABG).

Pregnancy & Lactation

Use of Naproxen Plus Tablet should be avoided during pregnancy and breastfeeding unless the benefit of the other tablet outweighs the possible risk to the fetus.

Precautions & Warnings

• Avoid Naproxen Plus Tablet if you are allergic to it.
• Long-term use of NSAIDs like naproxen may increase the risk of heart attack, stroke, and stomach ulcers.
• Higher risk of ulcers if you have a history of ulcers, bleeding disorders, alcoholism, or multiple diseases.
• Elderly patients are at greater risk for gastrointestinal bleeding problems, so their dose should be limited.
• Not recommended for pregnant women, especially in the third trimester, as it may harm the baby. Consult a doctor if pregnant or breastfeeding.
• Not recommended for children unless prescribed by a doctor.
• Do not take other NSAIDs for pain relief along with Naproxen Plus Tablet unless prescribed.
• Prolonged use of esomeprazole may affect bone health, so taking Vitamin D and calcium might be advised by the doctor.
• Avoid alcohol with Naproxen Plus Tablet to reduce the risk of stomach bleeding or ulcer.

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.