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Comet 500mg Tablet

Generic: Metformin Hydrochloride

Type: Tablet

Pack Size: 10 Pcs

  • Used to treat type 2 diabetes in adults and children
  • Helps control blood sugar levels
  • Available in both quick release and extended-release tablets
  • Should be used with caution in patients with liver or kidney disease
  • Dosage may need to be adjusted in some patients
  • May cause gastrointestinal side effects, such as nausea, vomiting, diarrhea, and abdominal pain
  • Regular monitoring of kidney and liver function is advisable while taking this medication

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Discount Price: ৳ 37.39
MRP: ৳ 40.2 7% Off

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✅ Description:

Comet 500mg is a medication that belongs to the biguanide class and is primarily used to treat type 2 diabetes. It works by increasing peripheral glucose uptake and utilization, lowering hepatic glucose production, and decreasing intestinal glucose absorption. It is available in both quick release and extended-release tablets.

Safety Advices


Alcohol
UNSAFE

It is unsafe to consume alcohol with Comet 500.


Pregnancy
SAFE IF PRESCRIBED

Limited human studies have been conducted on the use of Comet 500 during pregnancy, but it is generally considered safe. Animal studies have shown little to no adverse effects on fetal development.


Breastfeeding
SAFE IF PRESCRIBED

Although limited human data suggests that Comet 500 is likely safe to use during breastfeeding, caution should still be exercised as there is not enough evidence to confirm that the drug does not pose any significant risk to the baby. It is advised to consult with a healthcare professional before taking Comet 500 while breastfeeding.


Driving
CAUTION

Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.


Kidney
CAUTION

Caution should be exercised when using Comet 500 in patients with kidney disease, and dosage adjustment may be necessary. It is not recommended to use Comet 500 in patients with severe kidney disease. Regular monitoring of kidney function tests is advised while taking this medication. It is recommended to consult with a doctor before taking Comet 500.


Liver
CAUTION

Caution is advised when using Comet 500 in patients with liver disease, and dosage adjustment may be necessary. It is recommended to consult with a doctor before taking Comet 500. The medication is typically started with a low dose in patients with mild to moderate liver disease, and is not recommended for use in patients with severe liver disease.

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✔️ Indications of Comet 500mg
  • Treatment of type 2 diabetes mellitus, especially in overweight people, when food and exercise alone are unable to provide appropriate glycemic control.
  • Metformin can be used alone or in conjunction with other oral antidiabetic drugs or insulin in adults.
  • Metformin can be taken alone or in conjunction with insulin in children and adolescents as young as ten years old.
  • In overweight type 2 diabetes adult patients treated with metformin as first-line treatment following diet failure, there was a decrease in diabetic complications.
✔️ Pharmacology

Metformin is an antihyperglycemic medication of the biguanide class that is used to treat type 2 diabetes. Both baseline and postprandial plasma glucose levels are reduced. It has a different mode of action than sulfonylureas and does not cause hypoglycemia. Metformin increases insulin sensitivity by increasing peripheral glucose uptake and utilization. It lowers hepatic glucose production, lowers intestinal glucose absorption, and lowers hepatic glucose production.

✔️ Dosage & Administration of Comet 500mg

Comet 500 Dosage:

Metformin Hydrochloride dosage is individualized based on effectiveness and tolerance, without surpassing recommended daily limits.

Adults: Metformin typically begins at 500 mg twice daily or 850 mg once daily with meals. Increase by 500 mg weekly or 850 mg every two weeks, up to 2000 mg daily in divided doses. Glucomin's maximum daily dose is 2550 mg for enhanced glycemic control.

Children start with Metformin 500 mg twice daily, increasing weekly to 2000 mg daily in divided doses.

Metformin extended-release tablets must be swallowed whole, not crushed or chewed.

Adults use Metformin XR 500 mg once daily with dinner, escalating by 500 mg weekly to a max of 2000 mg once daily with dinner, or 1000 mg twice daily with supper if preferred. Patients on Metformin quick-release can shift to Metformin extended-release up to daily max.

Children: Metformin XR hasn't been studied in children.

Kidney impaired: Avoid Metformin if eGFR is below 30 mL/min/1.73 m². Evaluate risks if eGFR drops below 45 mL/min/1.73 m².

✔️ Interaction of Comet 500mg

Carbonic anhydrase (Topiramate, Zonisamide) co-administration may raise the risk of lactic acidosis. Drugs that decrease Metformin clearance (Ranolazine, Dolutegravir, Cimetidine) may cause Metformin buildup. Metformin's effect on lactate metabolism can be amplified by alcohol.

✔️ Contraindications

Hypersensitivity to the active substance or to any of the excipients.

Any type of acute metabolic acidosis (such as lactic acidosis, diabetic ketoacidosis).

Severe renal failure (GFR <30 mL/min).

Acute conditions with the potential to alter renal function such as dehydration, severe infection, shock.

Acute or chronic disease, which may cause tissue hypoxia such as 

  • cardiac or respiratory failure,
  • recent myocardial infarction,
  • shock,
  • Hepatic insufficiency,
  • acute alcohol intoxication,
  • alcoholism.
✔️ Side Effects of Comet 500mg

Hemolytic anemia is a blood and lymphatic system disease that is not well understood.

Metabolism and nutrition disorders: 

Very rare: 

Lactic acidosis. Decrease of vitamin B12 absorption with a decrease of serum levels during long-term use of metformin. Consideration of such etiology is recommended if a patient presents with megaloblastic anemia. Cases of peripheral neuropathy in patients with vitamin B12 deficiency have been reported in post-marketing experience (frequency not known)

Taste disturbance is a common nervous system disease. Encephalopathy is a condition that is currently unknown.

Gastrointestinal disorders: 

Very common: 

Gastrointestinal disorders, such as nausea, vomiting, diarrhea, abdominal pain, and loss of appetite. These undesirable effects occur most frequently during the initiation of therapy and resolve spontaneously in most cases. To prevent them, it is recommended that metformin be taken in 2 or 3 daily doses during or after meals. A slow increase of the dose may also improve gastrointestinal tolerability.

Isolated instances of liver function test problems or hepatitis resolving after metformin cessation are extremely rare.

Skin and subcutaneous tissue disorders: 

  • Erythema,
  • pruritus, and
  • urticaria are extremely infrequent.
✔️ Pregnancy & Lactation

Uncontrolled diabetes (gestational or permanent) during pregnancy is linked to an increased risk of congenital malformations and perinatal death. When a patient intends to become pregnant or is pregnant, it is advised that diabetes be managed with insulin rather than metformin to keep blood glucose levels as near to normal as possible, reducing the risk of fetal abnormalities.

Metformin is secreted in human breast milk during breastfeeding. In breastfed newborns/infants, no harmful effects were found. Breastfeeding is not suggested when using metformin since there is insufficient data. The benefits of nursing and the possible danger of harmful effects on the kid should be considered while deciding whether or not to stop breastfeeding.

✔️ Precautions & Warnings for Comet 500mg

Comet 500 is known to be eliminated in large amounts via the kidneys, and the danger of Metformin buildup and lactic acidosis rises as renal function declines. Metformin has been linked to a reduction in vitamin B12 levels. 

When combined with insulin or an insulin secretagogue, it raises the risk of hypoglycemia.

✔️ Storage Conditions

Keep the temperature below 30°C and away from light and moisture. Keep out of children's reach.

Frequently Asked Questions (FAQ)

Comet 500mg is a brand of Metformin, an antihyperglycemic medication used to treat type 2 diabetes.

The dosage of Comet 500mg should be customized based on efficacy and tolerance, and taken with meals. The starting dose is usually 500mg twice a day or 850mg once a day, with increases in dosage done in 500mg weekly increments of 850mg every two weeks, up to a maximum of 2000mg per day, given in split doses.

Some common side effects of Comet 500mg include gastrointestinal disorders, such as nausea, vomiting, diarrhea, abdominal pain, and loss of appetite. Rare side effects include lactic acidosis, vitamin B12 deficiency, and peripheral neuropathy. Hemolytic anemia, taste disturbance, and skin reactions may also occur.

It is recommended that diabetes be managed with insulin rather than Metformin during pregnancy. Metformin is secreted in human breast milk, and the potential risk to the infant is unknown.

If you miss a dose of Comet 500mg, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed dose.

Alcohol can amplify the effect of Metformin on lactate metabolism, so it is recommended to avoid excessive alcohol consumption while taking Comet 500mg.

If you experience side effects while taking Comet 500mg, contact your healthcare provider for advice. In some cases, a change in dosage or medication may be necessary.
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Check our pricing section for Comet 500mg Tablet price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Pricing Information, Availability:
ePharma reserves the right to make adjustments to pricing, Products and Service offerings for reasons including, but not limited to, changing market conditions, Product discontinuation, Product unavailability, manufacturer price changes, supplier price changes and errors in advertisements. All orders are subject to Product availability and the availability of Personnel to perform the Services. Therefore, Seller cannot guarantee that it will be able to fulfill Customer’s orders. If Services are being performed on a time and materials basis, any estimates provided by Seller are for planning purposes only.

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