Comet XR 500mg is a medication used to treat type 2 diabetes by reducing glucose levels in the blood and improving insulin sensitivity. It is typically used when diet and exercise alone are insufficient to achieve adequate glycemic control, particularly in overweight individuals. The recommended initial dose for adults is 850mg once daily or 500mg twice daily with meals, and dosage may be increased over time as needed. Patients with kidney or liver disease should use this medication with caution, and dose adjustment may be necessary. Common side effects of Comet XR 500mg include gastrointestinal discomfort, such as nausea, vomiting, and diarrhea. Regular monitoring of kidney function and blood glucose levels is recommended while taking this medication to ensure safe use.
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Comet XR 500mg is a medication used to treat type 2 diabetes. It works by reducing glucose levels in the blood and improving insulin sensitivity. Some key points about Comet XR 500mg are:
It is unsafe to consume alcohol with Comet XR 500.
Comet XR 500 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Based on limited data, it is likely that Comet XR 500 is safe to use while breastfeeding and is unlikely to pose a significant risk to the baby.
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
It is important to use Comet XR 500 with caution in patients with kidney disease, as dose adjustment may be necessary. However, it is not recommended to use this medication in patients with severe kidney disease. To ensure safe use, regular monitoring of kidney function tests is advisable while taking Comet XR 500.
Patients with liver disease should use Comet XR 500 with caution and may require dose adjustment. It is recommended to consult with a doctor before taking this medication. In patients with mild to moderate liver disease, Comet XR 500 is typically initiated with a low dose, and it is not advised for use in patients with severe liver disease.
Comet XR 500mg is used for
The biguanide class of antihyperglycemic drug metformin is used to treat type 2 diabetes. Plasma glucose levels at rest and after meals are both decreased. It works in a different way from sulfonylureas and doesn't result in hypoglycemia. Metformin improves peripheral glucose uptake and utilization to increase insulin sensitivity. It decreases intestinal glucose absorption, which in turn decreases hepatic glucose production.
Metformin Hydrochloride Dosage: The dosage of metformin hydrochloride should be adjusted based on effectiveness and tolerance, but not to go over the highest recommended daily dosages.
The extended-release tablet of metformin should not be chewed, chopped, or crushed before being taken.
Co-administration of carbonic anhydrase (Topiramate, Zonisamide) may increase the risk of lactic acidosis. Drugs like Ranolazine, dolutegravir, and Cimetidine that lower Metformin clearance may contribute to Metformin buildup. Alcohol can enhance the impact of metformin on lactate metabolism.
Disorders of metabolism and nutrition:
An increased risk of congenital defects and perinatal mortality is associated with uncontrolled diabetes (gestational or permanent) during pregnancy. In order to keep blood glucose levels as close to normal as possible and lower the risk of fetal abnormalities, it is advised that diabetes be managed with insulin rather than metformin when a patient is planning to become pregnant or is already pregnant.
During breastfeeding, metformin is secreted in human breast milk. No negative effects were observed in newborns or infants who were breastfed. Metformin uses while nursing is not advised due to a lack of research. When deciding whether or not to stop breastfeeding, one should weigh the advantages with any potential risks to the child.
Keep the temperature below 30°C and away from light and moisture. Keep out of children's reach.
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