Isovent 200mcg (Misoprostol) Tablet is used for medical abortion and to treat post-delivery bleeding. It is used also for preventing stomach ulcers while you are under the medication of certain NSAID drugs; especially if you are at a greater risk or have a family medical history of ulcers. It can also help to decrease your risk of ulcer complications such as bleeding.
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Alcohol is known to cause excessive dizziness and if taken along with Isovent 200mcg Tablet and increase uterine bleeding.
It is exceedingly risky to use Misoprost tablet while pregnant. Research on pregnant women and animals has revealed severe risks to the growing infant. In case you are pregnant and have already taken this tablet, seek medical advice immediately.
Isovent 200mcg Tablet is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.
Do not drive or operate any heavy tools or machines if your ability is affected by Isovent 200mcg Tablet.
Isovent 200mcg Tablet to be taken with caution, especially if you have a history of Kidney diseases/conditions. The dose may have to be adjusted by your doctor.
Isovent 200mcg Tablet to be taken with caution, especially if you have a history of Liver diseases/conditions. The dose may have to be adjusted by your doctor.
Isovent 200mcg Tablet can help reduce the production of excessive stomach acid that may occur due to prolonged use of NSAIDs. By doing so, it aids in the healing of existing ulcers, prevents the formation of new ulcers, and provides relief from symptoms like acidity and heartburn that affect the gastrointestinal tract.
In addition, this medication also has effects on the uterine muscles. It stimulates their contractions, which can be useful in initiating labor pain, reducing postpartum bleeding, and inducing abortion in the early stages of pregnancy. Furthermore, it contributes to the softening and preparation of the cervix by breaking down cells and tissues surrounding it, particularly in advance of uterine procedures.
Misoprostol-
Misoprostol is well-absorbed by the body and undergoes rapid conversion to its active form, called Misoprostol acid, which is responsible for its clinical effects. Misoprostol acid can be detected in the bloodstream. When Misoprostol is taken with food, the maximum levels of Misoprostol acid in the blood are reduced. Additionally, the use of antacids along with Misoprostol can decrease the total availability of Misoprostol acid.
Misoprostol has two main properties: it inhibits gastric acid secretion, which helps reduce the production of stomach acid, and it has protective effects on the gastric mucosa (the lining of the stomach), as observed in animal studies. Nonsteroidal anti-inflammatory drugs (NSAIDs) can inhibit the production of prostaglandins, and a deficiency of prostaglandins in the gastric mucosa can lead to decreased secretion of bicarbonate (a substance that neutralizes stomach acid) and mucus. This deficiency may contribute to the damage that NSAIDs can cause to the gastric mucosa.
Misoprostol, on the other hand, can increase the production of bicarbonate and mucus in the stomach. However, it has been demonstrated in humans that this effect is seen at doses of 200 mcg and higher, which are also associated with the inhibition of gastric acid secretion. Therefore, it is not clear whether the ability of Misoprostol to reduce the risk of gastric ulcers is solely due to its antisecretory effect, its mucosal protective effect, or a combination of both.
In summary, Misoprostol has both antisecretory and mucosal protective properties. While it can increase bicarbonate and mucus production, its ability to reduce the risk of gastric ulcers may be attributed to its antisecretory effect, its mucosal protective effect, or a combination of both.
Dosage and administration of Misoprostol for different indications:
Antiulcerant (reducing the risk of NSAID-induced gastric ulcers):
Gynecological use (induction of labor):
NSAID-induced ulcer treatment and prophylaxis:
Termination of pregnancy:
Postpartum Hemorrhage (PPH) prophylaxis:
Postpartum Hemorrhage (PPH) treatment:
Renal Dose:
Isovent 200mcg Tablet has the following interactions with other medications and conditions:
Medicines for labor pain (Dinoprostone): There may be an increased risk of excessive uterine contractions and other adverse effects. It is important to avoid concomitant use or follow the specific instructions provided by your doctor.
Antacid (magaldrate): Concurrent use of antacids can reduce the effectiveness of the Isovent 200mcg Tablet. It is recommended to avoid taking antacids together with Isovent 200mcg Tablet or to separate their administration by a few hours.
Mineral supplements (magnesium carbonate, magnesium oxide) and medicines for constipation (magnesium hydroxide): These medications containing magnesium can enhance the gastrointestinal side effects of Isovent 200mcg Tablet, such as diarrhea. It is advisable to avoid or use them with caution, as directed by your doctor.
Blood pressure-lowering pills (quinapril): Concurrent use of quinapril and Isovent 200mcg Tablet may reduce the blood pressure-lowering effects of quinapril. Your doctor may need to adjust the dosage or monitor your blood pressure closely if you are taking these medications together.
Regarding drug-food interaction, it is recommended to avoid consuming grapefruit juice while taking Isovent 200mcg Tablet, as it may interfere with the metabolism and effectiveness of the medication.
Isovent 200mcg Tablet should not be given to patients with heart disease, as it can potentially worsen their condition. Additionally, caution should be exercised in patients with diarrhea, as Isovent 200mcg Tablet can increase the frequency and severity of diarrhea symptoms.
Misoprostol should not be taken by pregnant women to reduce the risk of ulcers induced by nonsteroidal anti-inflammatory drugs (NSAIDs) because it can cause miscarriage, premature birth, or birth defects. It is contraindicated in pregnancy.
Additionally, Misoprostol should not be taken by individuals with a history of allergy to prostaglandins, as it belongs to the prostaglandin class of medications. Allergic reactions to prostaglandins can be severe and potentially life-threatening.
It is important to follow the prescribing information and consult with a healthcare professional before starting any medication to ensure it is safe and appropriate for your specific circumstances.
Misoprostol, due to its abortifacient property, is contraindicated in pregnant women. However, in certain cases where women of childbearing potential require NSAID therapy and are at high risk of developing gastric or duodenal ulcers, Misoprostol may be prescribed after considering certain conditions:
The excretion of the active metabolite, Misoprostol acid, into breast milk is possible but has not been extensively studied. Due to the potential for serious adverse reactions in nursing infants, Misoprostol is not recommended for use by nursing mothers.
It is important to consult with a healthcare professional for a thorough evaluation of individual circumstances and to discuss the potential risks and benefits before considering the use of Misoprostol in women of childbearing potential.
Store in a cool and dry place, protected from light and moisture. Keep out of the reach of the children.
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