Jardian 10mg Tablet

✔️ Uses of Jardian 10mg Tablet

• Type 2 Diabetes

✔️ How does Jardian 10mg Tablet work?

Jardian 10mg Tablet works by blocking a protein (SGLT2) in your kidneys. This results in the removal of blood sugar (glucose) in your urine, thus lowering the amount of sugar in your blood. It also helps protect your heart from getting weaker and relieves your symptoms.

✔️ Side Effects of Jardian 10mg Tablet

• Thrush (fungal infection)
• Burning feeling when you pee
• Peeing more than normal
• Nausea
• Frequent Urge To Urinate
• Increased Thirst
• Urinary Tract Infection
• Mild skin rash or itchy skin
• Hives
• Stretching or pain when emptying the bladder

✔️ Quick Suggestions:

• Jardian 10 is used alone or together with other diabetes medicines to control blood sugar and avoid long-term complications.
• It may cause your body to lose too much fluid (dehydration) or you may urinate more often. Drink plenty of water and stay hydrated.
• It may cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
• Always carry some sugary food or fruit juice with you in case you experience hypoglycemia symptoms such as cold sweats, cool pale skin, tremor and anxiety.
• It can cause genital fungal and/or urinary tract infections (UTIs) in both females and males, so practice good hygiene.
• Monitor your blood sugar regularly while taking this medicine.
• Inform your doctor immediately if you experience constant dizziness, joint pain, cold-like symptoms or unexplained nausea/vomiting.

✔️ Indication

• Empagliflozin is used to improve glycemic control in persons with type 2 diabetes mellitus as a supplement to diet and exercise.
• In adult patients with type 2 diabetes mellitus with established cardiovascular disease, the goal is to lower the risk of cardiovascular death.

✔️ Pharmacology

Empagliflozin is an inhibitor of the sodium-glucose co-transporter-2 (SGLT-2). The SGLT2 co-transporters in the kidney are responsible for glucose reabsorption from the glomerular filtrate. SGLT2 inhibition has a glucuronic action, which inhibits renal absorption and lowers the renal glucose threshold, leading to higher glucose excretion. It also helps with weight loss and lowers blood pressure, as well as lowers hyperglycemia.

✔️ Dosage & Administration of Jardian 10mg Tablet

Recommended dose: The typical starting dose of Empagliflozin is 10 mg once daily. This can be taken in the morning with or without food.

Dose increase: For patients who tolerate Empagliflozin well, the dose may be increased to 25 mg once daily. However, the decision to increase the dose should be made by the healthcare provider based on individual patient factors and response to treatment.

Volume depletion: It is recommended to correct any volume depletion (low body fluid volume) in patients before initiating Empagliflozin. This is an important consideration, particularly for individuals with conditions such as low blood pressure or those taking diuretic medications that can contribute to volume depletion.

✔️ Interaction

Insulin: Jardian 10mg Tablet 10's may interact with insulin, which is used to lower blood sugar levels in individuals with diabetes. Your doctor may need to adjust your insulin dosage or monitor your blood sugar levels closely when using both medications together.

High blood pressure-lowering pills (hydrochlorothiazide, amlodipine): Jardian 10mg Tablet 10's may interact with these medications used to treat high blood pressure. Your doctor may need to monitor your blood pressure and adjust the dosage of these medications if necessary.

Water pills/diuretics (furosemide): Jardian 10mg Tablet 10's may interact with diuretics like furosemide, which are used to reduce fluid retention and lower blood pressure. Your doctor may need to monitor your fluid balance and electrolyte levels when using both medications.

Antibiotics used for eye infections (gatifloxacin): Jardian 10mg Tablet 10's may interact with gatifloxacin, an antibiotic used to treat eye infections. Your doctor may need to monitor your blood sugar levels more closely when using these medications together.

Anti-hypertensive (metoprolol): Jardian 10mg Tablet 10's may interact with metoprolol, a medication used to treat high blood pressure and certain heart conditions. Your doctor may need to monitor your blood pressure and adjust the dosage of metoprolol if necessary.

Steroids (prednisolone): Jardian 10mg Tablet 10's may interact with prednisolone, a steroid medication. Your doctor may need to monitor your blood sugar levels more closely when using these medications together.

It's important to note that this is not an exhaustive list of all possible drug interactions. Always inform your doctor about all the medications you are taking, including over-the-counter drugs and herbal supplements, to ensure the safe and effective use of Jardian 10mg Tablet 10's.

Regarding the drug-food interaction, as mentioned previously, it is advisable to avoid consuming alcoholic beverages while taking Jardian 10mg Tablet 10's. Alcohol consumption may increase the risk of lactic acidosis and hypoglycemia, which are serious conditions.

Furthermore, individuals with specific medical conditions such as vitamin B12 deficiency, kidney problems, liver problems, cardiovascular disease, and low blood sugar levels should avoid Jardian 10mg Tablet 10's, as it may worsen these conditions. It is important to discuss your medical history with your doctor before starting treatment with Jardian 10mg Tablet 10's to ensure it is safe and appropriate for you.

✔️ Contraindications

Patients having a history of serious allergic reactions to Empagliflozin or any of its constituents, severe renal impairment, end-stage renal disease, or dialysis should not take Empagliflozin.

✔️ Pregnancy & Lactation

Empagliflozin, the active ingredient in Jardian 10mg Tablet 10's, has not been extensively studied in pregnant women in well-controlled trials. The use of empagliflozin during pregnancy should only be considered if the potential benefits outweigh the potential risks to the fetus, and it should be used under the guidance and supervision of a healthcare professional.

Additionally, there is limited information available regarding the excretion of empagliflozin in human milk. It is not known whether empagliflozin is excreted in breast milk. Therefore, it is advisable to consult with your doctor before taking Jardian 10mg Tablet 10's if you are breastfeeding.

Your doctor will be able to assess your specific situation and provide you with the most appropriate advice regarding the use of empagliflozin during pregnancy or while breastfeeding, considering the potential risks and benefits involved. It is important to prioritize the safety and well-being of both the mother and the baby in such cases.

✔️ Precautions & Warnings

• Allergy: If you are allergic to any of the ingredients in Jardian 10mg Tablet 10's, do not consume it.
• Pre-existing conditions: Inform your doctor if you have heart abnormalities, diabetic ketoacidosis, skin problems, acute pancreatitis, low blood sugar levels, or kidney or liver problems. Hypotension: Prior to starting Empagliflozin, it is important to assess the patient's volume status and correct any hypovolemia, especially in elderly patients, those with renal impairment, those with low systolic blood pressure, and patients taking diuretics. Empagliflozin can cause intravascular volume contraction, which may lead to hypotension (low blood pressure).
• Impairment in Renal Function: Renal function should be evaluated before initiating Empagliflozin and periodically thereafter. Empagliflozin can increase serum creatinine levels and decrease estimated glomerular filtration rate (eGFR), which are measure of kidney function.
• Hypoglycemia: In patients taking insulin or an insulin secretagogue (a medication that stimulates insulin secretion), a lower dose of insulin or the insulin secretagogue may be considered to reduce the risk of hypoglycemia (low blood sugar levels) when using Empagliflozin.
• Genital mycotic infections: Monitoring and treatment should be done if indicated. Empagliflozin has been associated with an increased risk of genital mycotic (fungal) infections, such as yeast infections in the genital area.
• Urinary Tract Infections: Monitoring and appropriate treatment should be conducted for urinary tract infections as needed. Empagliflozin has been associated with an increased risk of urinary tract infections.
• Increased LDL-C: Monitoring and treatment should be initiated if required. Empagliflozin use has been associated with a slight increase in low-density lipoprotein cholesterol (LDL-C), often referred to as "bad" cholesterol. If necessary, treatment to manage elevated LDL-C levels should be considered.
• Pregnancy and breast-feeding: Consult your doctor before taking Jardian 10mg Tablet 10's if you are pregnant or breastfeeding.
• Alcohol consumption: Avoid drinking alcohol while taking Jardian 10mg Tablet 10's, as it may produce unpleasant side effects.
• Medications and medical history: Inform your doctor about all the medications you are taking, including over-the-counter drugs and herbal supplements, as well as your complete medical history. This will help rule out any potential unwanted side effects or interactions.

✔️ Storage Conditions

Keep away from light and moisture in a cool, dry location (below 30° C). Keep out of children's reach.