Pregabalin is used in adults to treat:
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Prelica 50mg Capsule contains pregabalin, which is an anticonvulsant medication used to treat neuropathic pain, certain forms of epilepsy, and generalized anxiety disorders. Here are some important points to note about Prelica 50mg Capsule:
Pregabalin controls seizures by reducing abnormal activity in the brain's nerve cells. It also alleviates pain by blocking the transmission of pain signals in the nervous system. Furthermore, it relieves anxiety by decreasing the release of specific brain chemicals associated with abnormal mood stimulation and anxiety.
Inform your doctor about any lung, liver, kidney, or heart problems you have or have had.
Disclose any history of drug abuse, as well as diabetes or other nerve or brain disorders.
Women of childbearing age should use suitable contraceptive methods while on Prelica 50mg Capsule therapy.
Elderly patients (above 65 years) with kidney problems should use Prelica 50mg Capsule with caution.
Regularly monitor blood sugar levels, as Prelica 50mg Capsule may affect them. Weight gain is also possible, particularly in diabetic patients.
Always follow your doctor's instructions regarding the use of Prelica 50mg Capsule and report any concerning symptoms or side effects to your healthcare provider.
Avoid consumption of alcohol while taking Prelica 50mg Capsule as it could increase your dizziness.
There is limited safety information available about the use of Prelica 50mg Capsules during pregnancy. Use effective contraception if you are a woman of childbearing age and taking this medicine.
Pregabalin passes into the breastmilk, but its effect on the breastfed baby is unknown. Thus, your doctor will decide whether to discontinue breastfeeding or discontinue the treatment with Prelica 50mg Capsule depending upon the benefits of the medicine for a nursing mother.
Do not drive or operate any heavy tools or machines if you feel dizzy or sleepy after taking Prelica 50mg of Capsule.
Prelica 50mg Capsule should be used with caution in patients with kidney diseases (such as decreased urination). Therefore, consult your doctor before taking it.
Prelica 50mg Capsule should be used with caution in patients with severe liver diseases. Therefore, consult your doctor before taking it.
Prelica 50mg Capsule acts by reducing the action of certain chemical substances in the brain. Thus, it impairs the transmission of pain signals from the brain and provides pain relief.
Major & minor side effects for Prelica 50mg Capsule
Pregabalin is recommended for the treatment of post-herpetic neuralgia and neuropathic pain brought on by diabetic peripheral neuropathy. Additionally, it is approved as an adjunctive treatment for patients aged one month and older experiencing partial-onset seizures. It can be used to treat fibromyalgia and neuropathic pain brought on by spinal cord damage.
Pregabalin, the active ingredient in Prelica 50mg Capsule, is indeed a structural derivative of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the central nervous system. However, pregabalin does not directly bind to GABAA, GABAB, or benzodiazepine receptors.
Pregabalin's precise mechanism of action is not fully understood. It is believed to bind with high affinity to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system. By binding to these sites, pregabalin modulates the calcium influx into neurons, which in turn affects the release of various neurotransmitters, including glutamate, noradrenaline, and substance P. This modulation of neurotransmitter release is thought to contribute to pregabalin's therapeutic effects.
Unlike some other medications, pregabalin is not active at serotonin or dopamine receptors, and it does not inhibit the reuptake of serotonin, dopamine, or noradrenaline.
When taken orally, pregabalin has a bioavailability equal to or greater than 90% and is not significantly influenced by the dosage. After absorption, it is primarily eliminated from the body through renal excretion as an unchanged drug. In individuals with normal renal function, the mean elimination half-life of pregabalin is approximately 6.3 hours.
The administration instructions for Prelica 50mg Capsule are as follows:
Please note that the use of Prelica 50mg Capsule in children has not been established, and the safety and efficacy in pediatric patients have not been determined.
For patients with renal impairment, the dosage adjustment is as follows:
It is important to follow your physician's instructions regarding the correct dose and duration of therapy. Do not stop taking Prelica 50mg Capsule without consulting your doctor. Swallow the capsule whole with a glass of water and do not crush or chew it.
It is important to be aware of the interactions between Prelica 50mg Capsule and other medications or medical conditions. Here is the information regarding the mentioned interactions:
Lorazepam: When using Lorazepam or other medications for sleep disorders or anxiety problems, inform your doctor. Taking Prelica 50mg Capsule 10's together with these medicines can increase the risk of adverse effects such as dizziness, drowsiness, confusion, and lack of focus. Special precaution is advised, particularly in elderly individuals.
Pioglitazone: Inform your doctor if you are taking Pregabalin before starting Pioglitazone or any other medication used to control high blood sugar levels. Using these medications together may increase the risk of weight gain, fluid retention, and heart failure. Your doctor may consider adjusting the dose and closely monitoring your condition if you need to use these medicines together.
Ramipril: If you are taking Ramipril or any other medication from the class of ACE inhibitors for lowering blood pressure, report it to your doctor. Using Prelica 50mg Capsule 10's with ACE inhibitors can increase the risk of fluid retention and associated adverse effects on the heart.
Oxycodone: Inform your doctor if you are using any opiate pain medicines before starting Pregabalin. Taking these medications together can cause severe dizziness, confusion, and lack of coordination, especially in elderly individuals or those with a history of emotional disturbances, suicidal thoughts, alcohol abuse, or drug abuse. If you experience any such effects while using them together, it should be reported to your doctor.
Interaction with Disease:
Angioedema: Use Prelica 50mg Capsule 10's with caution if you have a history of or are at risk of developing swellings of the inner layers of the skin (angioedema). These swellings can potentially cause airway blockage and be life-threatening.
It's crucial to inform your doctor about all the medications you are currently taking, including over-the-counter drugs, herbal supplements, and any underlying medical conditions, before starting Prelica 50mg Capsule 10's. This will help your doctor assess the potential interactions and make appropriate treatment decisions.
Pregabalin is not recommended for individuals who have a history of hypersensitivity to Pregabalin or any of its components.
Pregabalin, the active ingredient in Prelica 50mg Capsule, may cause harm to the fetus if used during pregnancy. It is important to consult with your healthcare provider before taking this medication if you are pregnant or planning to become pregnant.
Breastfeeding is not recommended while taking pregabalin. It is unknown whether pregabalin passes into breast milk and the potential risks to the nursing infant. It is advisable to discuss with your healthcare provider the potential benefits and risks of using this medication while breastfeeding.
It is essential to follow the guidance and recommendations of your healthcare provider regarding the use of pregabalin during pregnancy and lactation to ensure the safety of both the mother and the baby.
Store Prelica 50mg Capsule below 30°C protected from light and moisture. Keep it out of the reach of children and pets.
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