Prelica 50mg | 10pcs | Box | View Uses, Dosage, Interaction | ePharma
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Prelica 50mg Capsule

Generic: Pregabalin

Type: Capsule

Pack Size: 10 Pcs

Pregabalin is used in adults to treat:

  • Peripheral and central neuropathic pain
  • Epilepsy (fits or seizures) in combination with other medicines
  • Generalized Anxiety Disorder

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Discount Price: ৳ 139.5
MRP: ৳ 150 7% Off

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✅ Description:

Prelica 50mg Capsule contains pregabalin, which is an anticonvulsant medication used to treat neuropathic pain, certain forms of epilepsy, and generalized anxiety disorders. Here are some important points to note about Prelica 50mg Capsule:

  • Neuropathic pain: Prelica 50mg Capsule is used to treat long-lasting nerve pain caused by nerve fiber damage. It helps alleviate various pain sensations such as burning, shooting, throbbing, or stabbing pain, along with tingling or numbness. It may also improve mood, and sleep, and reduce fatigue associated with nerve damage affecting the brain.
  • Epilepsy: Prelica 50mg Capsule can be used in combination with other antiepileptic medicines to control seizures in certain forms of epilepsy.
  • Anxiety disorders: In cases where other medications are ineffective, Prelica 50mg Capsule may be used to treat severe anxiety that significantly impacts daily activities.

Pregabalin controls seizures by reducing abnormal activity in the brain's nerve cells. It also alleviates pain by blocking the transmission of pain signals in the nervous system. Furthermore, it relieves anxiety by decreasing the release of specific brain chemicals associated with abnormal mood stimulation and anxiety.

Inform your doctor about any lung, liver, kidney, or heart problems you have or have had.

Disclose any history of drug abuse, as well as diabetes or other nerve or brain disorders.

Women of childbearing age should use suitable contraceptive methods while on Prelica 50mg Capsule therapy.

Elderly patients (above 65 years) with kidney problems should use Prelica 50mg Capsule with caution.

Regularly monitor blood sugar levels, as Prelica 50mg Capsule may affect them. Weight gain is also possible, particularly in diabetic patients.

Always follow your doctor's instructions regarding the use of Prelica 50mg Capsule and report any concerning symptoms or side effects to your healthcare provider.

Safety Advices


Alcohol
UNSAFE

Avoid consumption of alcohol while taking Prelica 50mg Capsule as it could increase your dizziness.


Pregnancy
CONSULT YOUR DOCTOR

There is limited safety information available about the use of Prelica 50mg Capsules during pregnancy. Use effective contraception if you are a woman of childbearing age and taking this medicine.


Breastfeeding
CONSULT YOUR DOCTOR

Pregabalin passes into the breastmilk, but its effect on the breastfed baby is unknown. Thus, your doctor will decide whether to discontinue breastfeeding or discontinue the treatment with Prelica 50mg Capsule depending upon the benefits of the medicine for a nursing mother.


Driving
CAUTION

Do not drive or operate any heavy tools or machines if you feel dizzy or sleepy after taking Prelica 50mg of Capsule.


Kidney
CAUTION

Prelica 50mg Capsule should be used with caution in patients with kidney diseases (such as decreased urination). Therefore, consult your doctor before taking it.


Liver
CAUTION

Prelica 50mg Capsule should be used with caution in patients with severe liver diseases. Therefore, consult your doctor before taking it.

Similar Products

✔️ Uses of Prelica 50mg Capsule
  • Diabetic Neuropathy
  • Postherpetic Neuralgia
  • Epilepsy
  • Fibromyalgia
  • Neuropathic pain
  • Generalized anxiety disorder
✔️ How does Prelica 50mg Capsule work?

Prelica 50mg Capsule acts by reducing the action of certain chemical substances in the brain. Thus, it impairs the transmission of pain signals from the brain and provides pain relief.

✔️ Side Effects of Prelica 50mg Capsule

Major & minor side effects for Prelica 50mg Capsule

  • Difficulty in breathing
  • Chest tightness
  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Unusual tiredness and weakness
  • Blurred vision
  • Drowsiness
  • Dry mouth
  • Headache
  • Lack of coordination
  • Trouble sleeping
  • Loss of bladder control
  • Burning, numbness, and tingling in the arms and feet
  • Nausea
  • Weight gain
  • Confusion
✔️ Quick Suggestions:
  • Pregabalin may cause drowsiness, so refrain from driving or engaging in activities that require concentration until you know how the medication affects you.
  • If you experience blurring or loss of vision, inform your doctor immediately.
  • Include fruits, vegetables, whole grains, and omega-3-rich foods in your diet. Avoid fried foods, high-fat dairy products, pastries, and processed foods, as they may worsen neuropathic pain.
  • Regular exercise and maintaining a healthy weight can be beneficial.
  • Prolonged use of Prelica 50mg Capsule may lead to dependence, both mentally and physically. Follow your doctor's guidance regarding the duration of treatment.
  • Inform your doctor if you experience any unusual changes in mood or behavior, new or worsening depression, or if you have thoughts of self-harm.
  • Do not abruptly stop taking the medication without consulting your doctor, as it may worsen your underlying condition. It's important to follow a gradual tapering-off process under medical supervision.
✔️ Indication

Pregabalin is recommended for the treatment of post-herpetic neuralgia and neuropathic pain brought on by diabetic peripheral neuropathy. Additionally, it is approved as an adjunctive treatment for patients aged one month and older experiencing partial-onset seizures. It can be used to treat fibromyalgia and neuropathic pain brought on by spinal cord damage.

✔️ Pharmacology

Pregabalin, the active ingredient in Prelica 50mg Capsule, is indeed a structural derivative of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the central nervous system. However, pregabalin does not directly bind to GABAA, GABAB, or benzodiazepine receptors.

Pregabalin's precise mechanism of action is not fully understood. It is believed to bind with high affinity to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system. By binding to these sites, pregabalin modulates the calcium influx into neurons, which in turn affects the release of various neurotransmitters, including glutamate, noradrenaline, and substance P. This modulation of neurotransmitter release is thought to contribute to pregabalin's therapeutic effects.

Unlike some other medications, pregabalin is not active at serotonin or dopamine receptors, and it does not inhibit the reuptake of serotonin, dopamine, or noradrenaline.

When taken orally, pregabalin has a bioavailability equal to or greater than 90% and is not significantly influenced by the dosage. After absorption, it is primarily eliminated from the body through renal excretion as an unchanged drug. In individuals with normal renal function, the mean elimination half-life of pregabalin is approximately 6.3 hours.

✔️ Dosage & Administration of Prelica 50mg Capsule

The administration instructions for Prelica 50mg Capsule are as follows:

  • It may be taken with or without food.
  • For adults with neuropathic pain or postherpetic neuralgia: The initial dose is 150 mg per day, which may be increased to 300 mg per day after 3-7 days. The maximum dose is 600 mg per day, given in 2 or 3 divided doses.
  • For adults with diabetic peripheral neuropathic pain: The initial dose is 50 mg taken orally every 8 hours. The maintenance dose may be increased to 100 mg taken orally every 8 hours within 1 week if needed. The maximum daily dose should not exceed 300 mg.
  • For adults as an adjunct in partial seizures: The initial dose is 150 mg per day, which may be increased to 300 mg per day after one week. The maximum dose is 600 mg per day, given in 2 or 3 divided doses.
  • For adults with fibromyalgia: The initial dose is 150 mg per day, which may be increased to 300 mg per day after one week. The maximum dose is 450 mg per day if needed. All doses should be given in 2 or 3 divided doses.

Please note that the use of Prelica 50mg Capsule in children has not been established, and the safety and efficacy in pediatric patients have not been determined.

For patients with renal impairment, the dosage adjustment is as follows:

  • Hemodialysis: 25-100 mg immediately after each 4-hour hemodialysis session.
  • Creatinine clearance (CrCl) 30 to <60 mL/min: 75 mg per day. The maximum dose is 300 mg per day.
  • CrCl 15 to <30 mL/min: Initially, 25-50 mg per day. The maximum dose is 150 mg per day.
  • CrCl <15 mL/min: Initially, 25 mg per day. The maximum dose is 75 mg per day.

It is important to follow your physician's instructions regarding the correct dose and duration of therapy. Do not stop taking Prelica 50mg Capsule without consulting your doctor. Swallow the capsule whole with a glass of water and do not crush or chew it.

✔️ Interaction

It is important to be aware of the interactions between Prelica 50mg Capsule and other medications or medical conditions. Here is the information regarding the mentioned interactions:

Lorazepam: When using Lorazepam or other medications for sleep disorders or anxiety problems, inform your doctor. Taking Prelica 50mg Capsule 10's together with these medicines can increase the risk of adverse effects such as dizziness, drowsiness, confusion, and lack of focus. Special precaution is advised, particularly in elderly individuals.

Pioglitazone: Inform your doctor if you are taking Pregabalin before starting Pioglitazone or any other medication used to control high blood sugar levels. Using these medications together may increase the risk of weight gain, fluid retention, and heart failure. Your doctor may consider adjusting the dose and closely monitoring your condition if you need to use these medicines together.

Ramipril: If you are taking Ramipril or any other medication from the class of ACE inhibitors for lowering blood pressure, report it to your doctor. Using Prelica 50mg Capsule 10's with ACE inhibitors can increase the risk of fluid retention and associated adverse effects on the heart.

Oxycodone: Inform your doctor if you are using any opiate pain medicines before starting Pregabalin. Taking these medications together can cause severe dizziness, confusion, and lack of coordination, especially in elderly individuals or those with a history of emotional disturbances, suicidal thoughts, alcohol abuse, or drug abuse. If you experience any such effects while using them together, it should be reported to your doctor.

Interaction with Disease:

Angioedema: Use Prelica 50mg Capsule 10's with caution if you have a history of or are at risk of developing swellings of the inner layers of the skin (angioedema). These swellings can potentially cause airway blockage and be life-threatening.

It's crucial to inform your doctor about all the medications you are currently taking, including over-the-counter drugs, herbal supplements, and any underlying medical conditions, before starting Prelica 50mg Capsule 10's. This will help your doctor assess the potential interactions and make appropriate treatment decisions.

✔️ Contraindications

Pregabalin is not recommended for individuals who have a history of hypersensitivity to Pregabalin or any of its components.

✔️ Pregnancy & Lactation

Pregabalin, the active ingredient in Prelica 50mg Capsule, may cause harm to the fetus if used during pregnancy. It is important to consult with your healthcare provider before taking this medication if you are pregnant or planning to become pregnant.

Breastfeeding is not recommended while taking pregabalin. It is unknown whether pregabalin passes into breast milk and the potential risks to the nursing infant. It is advisable to discuss with your healthcare provider the potential benefits and risks of using this medication while breastfeeding.

It is essential to follow the guidance and recommendations of your healthcare provider regarding the use of pregabalin during pregnancy and lactation to ensure the safety of both the mother and the baby.

✔️ Precautions & Warnings
  • Allergy and contraindications: Do not take Prelica 50mg Capsule if you are allergic to any of its components. Inform your doctor about any symptoms of suicidal ideation or behavior, drug addiction, chronic lung diseases, muscle weakness, heart problems, or liver/kidney impairment.
  • Pregnancy and breast-feeding: Caution is required when using Prelica 50mg Capsule 10's in pregnant or breastfeeding women. Consult with your doctor before taking this medication if you are pregnant or breastfeeding.
  • Use in children: Prelica 50mg Capsule 10's has not been established as safe and effective for use in children under 18 years of age. It should not be given to children.
  • Interactions with opioids, sleeping pills, and tranquilizers: Avoid taking Prelica 50mg Capsule together with opioid analgesics or painkillers like oxycodone, as it can lead to respiratory failure, coma, or even death. Inform your doctor if you are taking sleeping pills or tranquilizers, as Prelica 50mg Capsule10's can interact with these medications and cause sleepiness, drowsiness, and dizziness, affecting your daily activities.
  • Swelling and angioedema: Seek immediate medical attention if you experience swelling of your face, mouth, tongue, lips, gums, neck, or throat (angioedema). Discontinue the medication and receive appropriate treatment.
  • Gradual discontinuation: When discontinuing Pregabalin, it should be tapered gradually over a minimum of 1 week to avoid withdrawal symptoms such as insomnia, nausea, headache, and diarrhea.
  • Creatine kinase elevations: Pregabalin treatment may be associated with elevated creatine kinase levels. If myopathy is diagnosed or suspected or if markedly elevated creatine kinase levels occur, the medication should be discontinued.
  • Vision check: Regular vision checks are recommended while taking Prelica 50mg Capsule 10's.
  • Platelet count and PR interval: Prelica 50mg Capsule 10's may decrease platelet count and prolong the PR interval. Monitor these parameters as advised by your doctor.
  • Driving and hazardous activities: Prelica 50mg Capsule 10's may impair your ability to drive, operate machinery, or engage in hazardous activities. Use caution and assess your individual response to the medication.
  • Monitoring and counseling: Monitor for visual disturbances, clinical worsening, suicidality, and unusual changes in behavior. Inform patients, caregivers, and families about the increased risk of suicidal thoughts and behavior associated with antiepileptic drugs.
  • Angioedema: Angioedema, including life-threatening cases requiring emergency intervention, has been reported during treatment with Prelica 50mg Capsule 10's. Discontinue therapy and seek immediate medical attention if laryngeal stridor or angioedema of the face, tongue, or glottis occurs.
  • Lactation: It is unknown if Prelica 50mg Capsule 10's is excreted in breast milk. It is not recommended for use during lactation.
✔️ Storage Conditions

Store Prelica 50mg Capsule below 30°C protected from light and moisture. Keep it out of the reach of children and pets.

Frequently Asked Questions (FAQ)

This medication is an anticonvulsant and is considered to be the first-line of treatment for neurotic pain, shingles, seizures and fibromyalgia.

This medication should be taken after food in a prescribed dosage.

If your forgot to take a dose of Prelica 50mg Capsule, take it as soon as you remember. However, if it is time to take the next dose of Prelica 50mg Capsule, skip the missed one and take the next dose at regular times. Do not take a double dose of Prelica 50mg Capsule to compensate the missed dose.

Prelica 50mg Capsule is generally not recommended for use in children and adolescents (under 18 years of age) due to lack of clinical safety data. Therefore, consult your doctor for advice.

yes

Yes, Prelica 50mg Capsule may cause weight gain because it increases your hunger.

You are advised to contact your doctor so that the dosage may be adjusted accordingly to use safely.

Prelica 50mg Capsule has a low abuse potential with limited physical and psychological dependence.
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Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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