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MIG 5mg Tablet is indicated for the treatment of:
- Neuropathic Pain
- Diabetic Peripheral Neuropathic Pain (DPNP)
- Postherpetic Neuralgia (PHN)
- Peripheral Neuropathic Pain (PNP)
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✅ Description:
Neuropathic Pain
Neuropathic pain is a complex, chronic pain state usually accompanied by tissue injury. It occurs when nerves in the central nervous system (CNS) or peripheral nervous system (PNS) are damaged or dysfunctional.
- Symptoms: Pain is often described as a burning, shooting, or stabbing sensation. It may also involve tingling, numbness, or a pins-and-needles feeling.
- Causes: This can be caused by injury, infection, diabetes, surgery, chemotherapy, or diseases such as multiple sclerosis.
- Treatment: Often involves medications like anticonvulsants, antidepressants, or specific neuropathic pain drugs like mirogabalin. Physical therapy, lifestyle changes, and pain management techniques are also common.
Diabetic Peripheral Neuropathic Pain (DPNP)
DPNP is a type of neuropathic pain that affects the peripheral nerves, primarily in the lower extremities, and is a common complication of diabetes.
- Symptoms: Symptoms include burning, tingling, or stabbing pain in the feet or legs, which may be worse at night. It can also involve numbness or loss of sensation.
- Causes: High blood sugar levels damage nerves and blood vessels over time, leading to peripheral neuropathy.
- Treatment: Management of blood glucose levels, along with pain relief medications like anticonvulsants (e.g., pregabalin, mirogabalin) and antidepressants. Lifestyle changes such as regular exercise, maintaining a healthy diet, and proper foot care are also crucial.
Postherpetic Neuralgia (PHN)
PHN is a persistent nerve pain that occurs in the area of a previous shingles (herpes zoster) infection. It can last for months or years after the shingles rash has healed.
- Symptoms: Severe pain in the area where the shingles rash occurred, which can be sharp, burning, or aching. Sensitivity to touch and temperature changes are also common.
- Causes: Caused by damage to the nerves during a shingles outbreak, which leads to chronic pain even after the rash resolves.
- Treatment: Antiviral medications can reduce the risk of PHN if taken early during the shingles outbreak. Pain management may include anticonvulsants, antidepressants, topical lidocaine, or capsaicin patches. Steroid injections and nerve blocks can also be considered.
Peripheral Neuropathic Pain (PNP)
PNP encompasses various conditions that cause pain due to nerve damage in the peripheral nervous system. This can include any nerve outside the brain and spinal cord.
- Symptoms: Symptoms are similar to other types of neuropathic pain and may include burning, shooting, or stabbing pain, along with tingling, numbness, and muscle weakness.
- Causes: Causes can range from physical injuries, infections, metabolic problems (such as diabetes), exposure to toxins, or other underlying conditions like cancer or autoimmune diseases.
- Treatment: Treatment focuses on addressing the underlying cause, managing symptoms with medications like anticonvulsants or antidepressants, and utilizing physical therapy and lifestyle modifications to improve function and reduce pain.
Each type of neuropathic pain requires a comprehensive approach to treatment, often involving a combination of medication, physical therapy, and lifestyle adjustments to manage symptoms and improve quality of life.
Safety Advices
Alcohol
UNSAFE
Mirogabalin may cause excessive drowsiness with alcohol.
Pregnancy
CONSULT YOUR DOCTOR
Safety profile during pregnancy and lactation is not established.
Breastfeeding
CONSULT YOUR DOCTOR
There is no information available on the safety profile on using in lactation.
CAUTION
MIG 5mg Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Use with caution in patients with kidney disease. Consult your doctor for dose adjustments.
CAUTION
Generally safe for use in patients with liver disease; no dose adjustment recommended.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Uses of MIG 5mg Tablet
- Neuropathic Pain
- Diabetic Peripheral Neuropathic Pain (DPNP)
- Postherpetic Neuralgia (PHN)
- Peripheral Neuropathic Pain (PNP)
✔️ Pharmacology
Mirogabalin belongs to the class of gamma amino acids and its derivatives. It selectively binds to the α2δ subunits of voltage-gated calcium channels (VGCCs), reducing calcium influx and inhibiting neurotransmitter release in presynaptic neuron endings. This inhibition decreases the hyper-excitability of central nervous system (CNS) neurons.
- Absorption: Rapidly absorbed after oral administration, with a median time to maximum plasma concentration of 0.5-1.5 hours.
- Protein Binding: Approximately 25%.
- Volume of Distribution: 64-88L.
- Metabolism: Primarily renal excretion (61-72% unchanged), with minor hepatic metabolism (13-20%).
- Elimination Half-life: 2-4.9 hours.
- Excretion: 99% through kidneys, 1% through feces.
✔️ The most reported adverse reactions include:
- Somnolence
- Dizziness
- Edema
- Weight gain
✔️ Rare Symptoms (Seek medical attention if these occur):
- Light-headedness, impaired consciousness, loss of consciousness (dizziness, somnolence, unconsciousness).
- General malaise, loss of appetite, nausea, vomiting, and jaundice (indicative of liver dysfunction).
✔️ Dosage & Administration
Adults:
- Initial dose: 5 mg twice daily.
- Gradually increase by 5 mg at weekly intervals to 15 mg twice daily.
- Dose range: Adjust between 10 mg and 15 mg twice daily based on age and symptoms.
Children and Adolescents:
- Safety and efficacy not established.
Hepatic Impairment:
- Mild to moderate: No significant adverse reaction with a single 15 mg dose.
- Severe: No data available.
Renal Impairment:
- Mild: Start with 5 mg twice daily, increase by 5 mg weekly to 10 mg.
- Moderate: Start with 2.5 mg twice daily, increase by 2.5 mg weekly to 7.5 mg twice daily.
- Severe: Start with 2.5 mg once daily, increase by 2.5 mg weekly to 7.5 mg once daily.
- Follow the doctor's advice for dosage adjustments.
✔️ Interaction
- With Medications:
- Cimetidine or Probenecid: May increase Mirogabalin plasma concentration.
- Alcohol or Lorazepam: Potentiates depressive effects on the CNS, causing excessive drowsiness.
- Cytochrome P450 Isoenzymes: Mirogabalin does not induce or inhibit cytochrome P450 isoenzymes.
✔️ Mirogabalin is contraindicated in:
- Patients with known hypersensitivity to Mirogabalin.
- Patients with mild to moderate hepatic and renal impairment.
✔️ Pregnancy & Lactation
- Use only if the therapeutic benefit outweighs the risks.
- Animal studies have shown presence in placental passage and transfer into milk.
- Consider therapeutic and breastfeeding benefits before continuing or discontinuing breastfeeding.
✔️ Precautions & Warnings
- May cause dizziness, somnolence, or loss of consciousness; avoid operating machinery or driving.
- Elderly patients should be cautious of falls and fractures.
- May cause weight gain, blurred vision, and double vision.
- Discontinue use and consult a doctor if an allergic reaction occurs.
- Dose adjustment is needed for patients with renal dysfunction.
- Consult with a doctor if taking other medications.
✔️ Storage Conditions:
- Store below 30°C in a dry place, away from light and moisture.
- Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
