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Sindola 2.5mg Tablet 10pcs
Mirogabalin binds selectively and potently to the α2δ subunits of voltage-gated calcium channels (VGCCs). This reduces calcium (Ca²⁺) influx and neurotransmission in the dorsal root ganglia (DRG), inhibiting the release of neurotransmitters in presynaptic neuron endings. This mechanism reduces neuronal hyperexcitability and alleviates pain.
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✅ Description:
Mirogabalin Besylate is prescribed for the treatment of:
- Neuropathic Pain
- Diabetic Peripheral Neuropathic Pain (DPNP)
- Postherpetic Neuralgia (PHN)
- Peripheral Neuropathic Pain (PNP)
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✔️ Commonly reported side effects include:
- Somnolence
- Dizziness
- Edema
- Weight Gain
If severe symptoms like loss of consciousness, jaundice, or persistent dizziness occur, discontinue use and consult a doctor.
✔️ Dosage: Sindola 2.5
- Adults: The initial dose is 5 mg taken orally twice daily. The dose may be increased by 5 mg weekly to a maximum of 15 mg twice daily.
- Adjustments should be made based on age and symptoms.
- Always follow the doctor’s advice for dosage.
✔️ Drug Interactions
- Cimetidine and Probenecid may increase Mirogabalin plasma concentrations.
- Combining Mirogabalin with lorazepam or alcohol can potentiate CNS depressive effects (e.g., drowsiness or sedation).
- Mirogabalin does not induce or inhibit cytochrome P450 isoenzymes.
✔️ Contraindications
- Hypersensitivity to Mirogabalin.
- Patients with mild to moderate hepatic or renal impairment.
✔️ Precautions & Warnings
- This medication may cause drowsiness, dizziness, or loss of consciousness. Avoid activities requiring alertness, such as driving or operating machinery.
- Use with caution in elderly patients due to an increased risk of falls and fractures.
- May cause blurred vision or double vision.
- Monitor for signs of weight gain.
- In case of allergic reactions, stop taking the medication and seek immediate medical attention.
✔️ Storage Instructions
- Store below 30°C in a dry place, away from light and moisture.
- Keep out of reach of children.
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