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Numira 5mg Tablet 1 Strip
Mirogabalin Besylate
- Neuropathic Pain
- Diabetic Peripheral Neuropathic Pain (DPNP)
- Postherpetic Neuralgia (PHN)
- Peripheral Neuropathic Pain (PNP)
Discount
Price: ৳ 188
MRP:
৳
200
6%
Off
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Cash on Delivery - All over Bangladesh
Regular Delivery - 12-24 Hours, Dhaka City* Charge Tk.39-59- Regular Delivery - 24-48 Hours, Other Cities* Charge Tk.99-110
ফ্রি ডেলিভারিঃ - ৯৯৯ টাকা+ অর্ডারে, ঢাকা
শহরে- ফ্রি ডেলিভারিঃ - ২৯৯৯ টাকা+ অর্ডারে, ঢাকার
বাহিরে
100% Genuine Products, Guaranteed
Safe & Secure Payments, Always
Fast, Secure & Efficient Delivery
Proper Packaging
- Cash on Delivery - All over Bangladesh
- Regular Delivery - 12-24 Hours, Dhaka City* Charge Tk.39-59
- Regular Delivery - 24-48 Hours, Other Cities* Charge Tk.99-110
- ফ্রি ডেলিভারিঃ - ৯৯৯ টাকা+ অর্ডারে, ঢাকা
শহরে
- ফ্রি ডেলিভারিঃ - ২৯৯৯ টাকা+ অর্ডারে, ঢাকার
বাহিরে
✅ Description:
Mirogabalin belongs to the class of gamma amino acids and their derivatives.
It selectively binds to the α2δ subunits of voltage-gated calcium channels (VGCCs). This reduces calcium influx and inhibits neurotransmitter release from presynaptic neurons, decreasing central nervous system (CNS) hyperexcitability.
- Rapid absorption after oral intake, with a time to maximum plasma concentration of 0.5-1.5 hours.
- Plasma protein binding is about 25%.
- Excretion: 99% via kidneys, 1% via feces.
Half-life: 2-4.9 hours.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Dosage & Administration:
Adult Dose:
- Initial dose: 5 mg twice daily.
- Gradually increase by 5 mg each week up to 15 mg twice daily.
- Adjust dose between 10 mg and 15 mg twice daily depending on age and symptoms.
Use in Children and Adolescents: Safety and efficacy not established.
Hepatic Impairment: No significant adverse reactions for mild to moderate impairment. No data for severe hepatic impairment.
Renal Impairment:
- Mild: Start with 5 mg twice a day, increase to 10 mg.
- Moderate: Start with 2.5 mg twice a day, increase to 7.5 mg.
- Severe: Start with 2.5 mg once a day, increase to 7.5 mg.
✔️ Side Effects:
- Common: Somnolence, dizziness, edema, weight gain.
- Rare: Liver dysfunction (loss of appetite, jaundice, nausea), and loss of consciousness.
✔️ Interactions:
- With Medicines: Co-administration with Cimetidine or Probenecid may raise plasma concentration.
- CNS Depressive Effects: If combined with Lorazepam, may increase sedative effects.
- Drug Transporters: Numira is a substrate for several transporters; avoid using with inhibitors of OAT1, OAT3, OCT2, MATE1, MATE2-K, or UGT as it may increase exposure.
- Food & Alcohol: No clinically relevant effect with food. Avoid alcohol as it may increase sedative effects.
✔️ Contraindications:
- Hypersensitivity to Mirogabalin.
- Mild to moderate hepatic and renal impairment.
✔️ Pregnancy & Lactation:
- Pregnancy: Use only if the benefit outweighs risks.
- Lactation: May transfer into breast milk, consider the benefits of breastfeeding before discontinuation.
✔️ Precautions & Warnings:
- May cause dizziness, somnolence, or loss of consciousness. Avoid dangerous activities like driving.
- Can cause weight gain, blurred vision, and double vision.
- Elderly patients should be cautious of falling and fractures.
- Dose adjustment needed in patients with renal dysfunction.
- Consult with a doctor before using with other medications.
✔️ Storage:
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
📦Pricing Information, Availability:
Product Availability & Pricing Notice
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