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Mirogabalin belongs to the gamma amino acid derivative class. It works by selectively binding to the α2δ subunits of voltage-gated calcium channels (VGCCs). This action reduces calcium influx into nerve cells, thereby decreasing neurotransmitter release from presynaptic neurons. As a result, it helps reduce the overactivity of neurons in the central nervous system (CNS), which is responsible for neuropathic pain.
After oral administration, Mirogabalin is rapidly absorbed, reaching peak plasma levels within approximately 0.5 to 1.5 hours. It has low protein binding (~25%) and a distribution volume of around 64–88 L. The drug is primarily eliminated unchanged through the kidneys (61–72%) via filtration and active secretion, while a small portion (13–20%) undergoes hepatic metabolism. Its elimination half-life ranges from about 2 to 4.9 hours, with nearly 99% excreted in urine and only about 1% in feces.
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100% Genuine Products, Guaranteed
Safe & Secure Payments, Always
Fast, Secure & Efficient Delivery
Proper Packaging
- Cash on Delivery - All over Bangladesh
- Regular Delivery: 24-48 Hours, Dhaka City* Charge Tk.39-59
- Regular Delivery: 48-96 Hours, Other Cities* Charge Tk.99-125
- ফ্রি ডেলিভারিঃ - ১৯৯৯ টাকা+ অর্ডারে, ঢাকা
শহরে
- ফ্রি ডেলিভারিঃ - ৪৯৯৯ টাকা+ অর্ডারে, ঢাকার
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- Google Play Store থেকে ডাউনলোড
- Apple Store থেকে ডাউনলোড
📲 মোবাইল অ্যাপ অর্ডারে সাশ্রয় বেশী
✅ Description:
Mirogabalin Besylate tablets are prescribed for the management of various types of nerve-related pain, including:
- Neuropathic pain
- Diabetic peripheral neuropathic pain (DPNP)
- Postherpetic neuralgia (PHN)
- Peripheral neuropathic pain (PNP)
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Side Effects
- Drowsiness (somnolence)
- Dizziness
- Edema (swelling)
- Weight gain
✔️ Dosage & Administration
Adults:
- Initial dose: 5 mg twice daily
- Gradually increase by 5 mg at intervals of at least one week
- Usual target dose: 15 mg twice daily
- Dose may be adjusted between 10 mg and 15 mg twice daily depending on patient response and tolerability
Children & Adolescents:
- Safety and efficacy have not been established
Hepatic Impairment:
- Mild to moderate impairment: generally well tolerated with a single 15 mg dose
- Severe impairment: insufficient data available
Renal Impairment:
- Mild: Start 5 mg twice daily → increase gradually to 10 mg twice daily
- Moderate: Start 2.5 mg twice daily → increase to 7.5 mg twice daily
- Severe: Start 2.5 mg once daily → increase to 7.5 mg once daily
✔️ Drug Interactions
With medicines:
- Co-administration with cimetidine or probenecid may increase plasma levels of Mirogabalin
- Use with lorazepam may enhance central nervous system (CNS) depression
- Mirogabalin is a substrate of transporters such as OAT1, OAT3, OCT2, MATE1, MATE2-K, and UGT
- Inhibitors of these transporters may increase drug exposure
With food & alcohol:
- Food does not significantly affect absorption
- Alcohol should be avoided as it may increase sedation and impair motor coordination
✔️ Mirogabalin should not be used in:
- Patients with known hypersensitivity to the drug
- Patients with mild to moderate hepatic or renal impairment
✔️ Pregnancy & Lactation
- Use during pregnancy only if the expected benefit outweighs potential risks
- Animal studies indicate placental transfer
- The drug may pass into breast milk; breastfeeding decisions should be made after evaluating risks and benefits
✔️ Precautions & Warnings
- May cause dizziness, drowsiness, or loss of consciousness; avoid driving or operating machinery
- Increased risk of falls, especially in elderly patients
- May cause weight gain and visual disturbances (blurred or double vision)
- Dose adjustment is necessary in renal impairment
- Discontinue immediately if allergic reactions occur
- Consult a doctor before combining with other medications
✔️ Storage:
- Store below 30°C in a dry place
- Protect from light and moisture
- Keep out of reach of children
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
