✔ 100% Authentic Product
Generic Name: Phenytoin Sodium 30/5mg/ml
Manufacturer/Distributor: Ambee Pharmaceuticals Ltd.
🛒 How to order this item?
✅ Description:
Indications
Parenteral phenytoin is used to treat generalized tonic-clonic seizures, as well as the prevention and treatment of seizures that occur during neurosurgery. Oral phenytoin can be replaced with intravenous phenytoin for short-term use. When oral phenytoin administration is not possible, parenteral phenytoin should be used.
Pharmacology
Phenytoin works as an anticonvulsant by increasing efflux or decreasing the influx of sodium ions across cell membranes in the motor cortex during nerve impulse generation, thereby stabilizing neuronal membranes and reducing seizure activity. It works as an antiarrhythmic by prolonging the effective refractory period and inhibiting the automaticity of the ventricular pacemaker.
Administration & Dosage
It's best if you take it with food. Do not administer feeds 2 hours before or after a dose to patients on nasogastric or other enteral feeds. Feeding times should be consistent throughout therapy. Switching dosage forms/brands without thinking about it is not a good idea.
Epilepsy: Oral
Adults: Start with 3-4 mg/kg per day in a single dose or divided doses. Alternatively, if necessary, start with 150-300 mg per day and gradually increase to 600 mg per day. 200-500 mg per day for maintenance.
Initially, 5 mg/kg per day, divided into 2-3 doses. 4-8 mg/kg per day in divided doses for maintenance. The maximum daily dose is 300 mg.
Interaction
The effects of other sedatives or ethanol may be amplified. Increases the toxicity of paracetamol and lithium. Acetazolamide raises the risk of osteomalacia. Acyclovir, antineoplastics, benzodiazepines, ciprofloxacin, CYP2C9 inducers (e.g. carbamazepine), CYP2C19 inducers (e.g. rifampin), folic acid, and vigabatrin all reduced serum levels/effects.
Contraindications
Patients with a history of hypersensitivity to phenytoin, its inactive ingredients, or other hydantoins should not take phenytoin sodium.
Because of the effect of parenteral phenytoin on ventricular automaticity, sinus bradycardia, sino-atrial block, second and third-degree A-V block, and Adams-Stokes syndrome can occur.
A history of phenytoin-related acute hepatotoxicity in the past.
Side Effect
Hypersensitivity, loss of appetite, headache, dizziness, tremor, transient nervousness, insomnia, GI disturbances (e.g. nausea, vomiting, constipation), gum tenderness and hyperplasia, acne, hirsutism, coarsening of facial features, rashes, and osteomalacia
Pregnancy & Lactation
Although there is evidence of human fetal risk, the benefits of use in pregnant women may outweigh the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
Precautions & Warnings
DM; hepatic impairment; hypoalbuminemia; porphyria; seizures (may increase the frequency of petit mal seizures); debilitated patients; elderly. Cardiovascular disease, e.g. sinus bradycardia, heart blocks; DM; hepatic impairment; hypoalbuminemia; porphyria; seizures (may increase the frequency of petit mal seizures). In hypotension, heart failure, or MI, use caution when administering IV medications, and keep a close eye on your blood pressure and ECG during treatment. IV administration should be done slowly to avoid hypotension, CNS depression, and cardiac arrhythmias.
Storage Conditions
Keep the temperature below 15-30°C and away from light and moisture. Keep out of children's reach.
Similar Products
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
Pricing Information, Availability:
ePharma reserves the right to make adjustments to pricing,
Products and Service offerings for reasons including, but not limited
to,
changing market conditions, Product discontinuation, Product
unavailability,
manufacturer price changes, supplier price changes and errors in
advertisements.
All orders are subject to Product availability and the availability of
Personnel to perform the Services.
Therefore, Seller cannot guarantee that it will be able to fulfill
Customer’s orders.
If Services are being performed on a time and materials basis, any
estimates provided
by Seller are for planning purposes only.
Reliable
All products displayed on ePharma are procured from govt. approved pharmaceuticals and verified licensed pharmacies from 2016.
Secure
ePharma uses Secure Sockets Layer (SSL) 128-bit 🔒 encryption and is Payment Card Industry DataSecurity Standard (PCI DSS) compliant.
Affordable
Find affordable medicine substitutes, save up to 50% on health products, up to 30% off on doctor consultations.
Social
Providing health care services under the health and beauty category with more than 170K Facebook audience and 10M+ reach.
Get more features!
Download the app now
- Pill reminder
- Prescription & Report
- Doctor consultation
- 24/7 helpline
