Zeptol CR 200mg Tablet

✔️ Uses of Zeptol CR 200mg Tablet

• Trigeminal Neuralgia
• Epilepsy

✔️ How does Zeptol CR 200mg Tablet work?

Zeptol CR 200 Tablet works by decreasing the excitability of the nerve cells in the brain. This helps in reducing seizure episodes and nerve pain.

✔️ Side Effects of Zeptol CR 200mg Tablet

• Blurred vision
• Diarrhea
• Nausea or Vomiting
• Muscle stiffness
• Headache
• Drowsiness
• Weight gain
• Yellow-colored eyes or skin
• Dry mouth
• Increased sweating
• Skin Rash
• Dizziness

✔️ Quick Suggestions:

1. Practice yoga daily.
2. Ensure you get enough sleep at night.
3. Limit screen time on devices like mobile phones and laptops.
4. Take your medication on time as directed by your doctor.
5. Be cautious of dizziness and sleepiness caused by the medication. Avoid driving or activities requiring mental focus until you understand its effects on you.
6. Regular tests may be needed to monitor blood cell levels while taking this medication.
7. Inform your doctor if you experience sudden mood changes or have suicidal thoughts.
8. If you notice a rash or other skin changes while on the medication, consult your doctor immediately.
9. Do not stop taking the medication suddenly without consulting your doctor, as it may increase the frequency of seizures.
10. For children with epilepsy, a ketogenic diet (low in carbohydrates and high in fats) is recommended.
11. Adolescents and adults may benefit from the Atkins diet (high fat and controlled carbohydrates).
12. Prioritize getting enough rest and sleep.
13. Avoid smoking and alcohol consumption.
14. Regular exercise, meditation, and yoga can help lower stress and improve coping skills.
15. Make adjustments in your living area to reduce the risk of physical injury during a seizure.
16. Consider installing an alarm or emergency device for assistance during a seizure.
17. Regularly monitor sodium levels while taking Zeptol CR 200 Tablet 10's to prevent hyponatremia.
18. Be aware that prolonged use of Zeptol CR 200 Tablet 10's may cause severe skin reactions such as Stevens Johnsons syndrome (SJS) and toxic epidermal necrolysis (TEN). If you notice any skin blisters or rashes, seek immediate medical attention.
19. Zeptol CR 200 Tablet 10's may cause low blood cell count, so inform your doctor if you notice any red or purple spots on your body.

✔️ Indication of Zeptol CR 200mg Tablet

Zeptol 200Mg Tablet Cr essentially treats nerve pain like trigeminal neuralgia as well as diabetic neuropathy. Moreover, the drug also effectively treats bipolar disorder. Zeptol 200Mg Tablet Cr functions as an anticonvulsant and decreases the occurrence of abnormal nerve impulses in the brain which can lead to severe reactions like seizures and acute pain.

✔️ Pharmacology

Carbamazepine works in the brain by inhibiting the activity in the thalamic nucleus ventralis. It also limits the spread of excitatory impulses at the synapses and reduces neuronal discharge by decreasing the influx of sodium ions across the cell membrane. These actions contribute to its anticonvulsant and mood-stabilizing effects, making it useful in the treatment of epilepsy and mood disorders.

Additionally, carbamazepine has an effect on the secretion of antidiuretic hormone (ADH) and its ability to promote water reabsorption in the kidneys. This can lead to increased water retention and help manage conditions like diabetes insipidus, where there is excessive thirst and urination due to impaired ADH function.

✔️ Dosage & Administration of Zeptol CR 200mg Tablet

• Zeptol CR 200mg Tablet is used to treat epilepsy and trigeminal neuralgia. For adults and children over 12 years of age, the initial dose is 200 mg twice a day for tablets or controlled-release tablets, or 1 teaspoon four times a day for suspension (total daily dose of 400 mg). The dosage can be increased weekly by up to 200 mg/day using a twice-daily, three-times-daily, or four-times-daily regimen until the optimal response is achieved.
• For children between 6-12 years, the initial dose is 100 mg twice a day for tablets or controlled-release tablets, or half a teaspoon four times a day for suspension (total daily dose of 200 mg). The dosage can be increased weekly by up to 100 mg/day using a twice-daily, three-times-daily, or four-times-daily regimen until the optimal response is achieved. The maximum daily dose should generally not exceed 1000 mg.
• For children under 6 years, the initial dose is 10-20 mg/kg/day twice or three times a day for tablets, or four times a day for suspension. The dosage can be increased weekly to achieve the optimal clinical response. The maintenance dose is usually below 35 mg/kg/day, and plasma levels should be measured if the response is not satisfactory.
• For trigeminal neuralgia, the initial dose is 100 mg twice a day for tablets or controlled-release tablets, or half a teaspoon four times a day for suspension (total daily dose of 200 mg). The dose can be increased by up to 200 mg/day in increments of 100 mg every 12 hours for tablets or controlled-release tablets, or 50 mg (half a teaspoon) four times a day for suspension, as needed to achieve pain relief. The total daily dose should not exceed 1200 mg. Maintenance doses of 400-800 mg daily are usually sufficient, but some patients may require up to 1200 mg daily.

Zeptol CR 200mg Tablet should be taken as advised by the physician, swallowed with a glass of water, and not crushed or chewed. It can be taken with or without meals. Patients should not stop taking the medication without consulting their doctor, as it may cause symptoms to reappear. Regular attempts should be made to reduce the dose to the minimum effective level or discontinue the drug, under the guidance of a healthcare professional.

✔️ Interaction

Drug-Drug Interactions:

• Zeptol CR 200 Tablet 10's may interact with antipsychotics, anti-anxiety medications, antidepressants, antibiotics, painkillers, anticonvulsants, anti-thyroid medications, anticoagulants, antihistamines, and certain vitamins.
• It is important to inform your doctor about all the medications you are taking, including over-the-counter drugs, herbal supplements, and vitamins, to avoid potential interactions.

Drug-Food Interactions:

• Avoid consuming alcohol while taking Zeptol CR 200 Tablet 10's as it may increase dizziness and sleepiness.
• Grapefruit juice should be avoided while taking Zeptol CR 200 Tablet 10's.
• Herbal preparations containing St. John's wort should also be avoided.

Drug-Disease Interactions:

• Zeptol CR 200 Tablet 10's may interact with various disease conditions, including depression, liver disease, kidney dysfunction, suicidal tendencies, irregular heartbeat, thyroid dysfunction, low sodium levels in the blood (hyponatremia), blood disorders, anticholinergic effects, fructose intolerance, and psychosis.
• It is crucial to inform your doctor about your medical history and any existing health conditions before starting Zeptol CR 200 Tablet 10's to prevent potential adverse effects or complications.

Always follow your doctor's advice, and if you have any concerns about possible interactions, consult your healthcare provider. They can adjust your medication regimen or provide alternative treatment options to ensure safe and effective use of Zeptol CR 200 Tablet 10's.

✔️ Contraindications

• If you are allergic to carbamazepine or any other ingredient of Zeptol CR 200 tablet.
• If you are allergic to tricyclic antidepressants such as clomipramine, imipramine, amitriptyline, nortriptyline, doxepin. Ask your doctor what these medicines are if you are not sure.
• If you have a type of heart block known as an atrioventricular block (AV block).
• If you have had a history of bone marrow depression (decreased number of those cells in the bone marrow that can develop into all types of blood cells).
• If you have a history of hepatic porphyrias (acute intermittent porphyria, variegate porphyria, porphyria, cutanea tarda).
• If you are on monoamine oxidase inhibitors medicine (MAO's like selegiline, rasagiline, phenelzine, and tranylcypromine). If you are not sure, carry the prescription or packet along with you.

✔️ Pregnancy & Lactation

The pregnancy category of D indicates that there is evidence of risk to the fetus based on human data, but potential benefits may still warrant its use in pregnant women if no safer alternatives are available.

For lactating women, while the drug is considered compatible with nursing according to the American Academy of Pediatrics (AAP), there is a possibility of adverse reactions in breastfeeding infants. Therefore, healthcare providers should carefully consider the importance of the drug's use to the mother before deciding to discontinue breastfeeding or continue using the drug.

As always, it is essential for pregnant and breastfeeding women to consult their healthcare provider before taking any medication to ensure the safety and well-being of both the mother and the baby.

✔️ Precautions & Warnings

• Do not take Zeptol CR 200 Tablet 10's if you are allergic to 'Carbamazepine' or any of its components.
• Avoid using Zeptol CR 200 Tablet 10's if you have serious heart problems, blood illnesses, bone marrow problems, hypothyroidism, glaucoma, urinary retention, osteoporosis, or if you have taken monoamine oxidase inhibitors (MAOIs) or St. John's wort in the last 14 days.
• Inform your doctor if you have low sodium levels in the blood or are taking medications that could lower sodium levels or use hormonal contraceptives.
• Do not stop taking Zeptol CR 200 Tablet 10's without consulting your doctor to avoid worsening seizure episodes.
• Avoid taking Zeptol CR 200 Tablet 10's during pregnancy unless prescribed by the doctor as it may cause serious congenital disabilities.
• It is generally safe to take Zeptol CR 200 Tablet 10's while breastfeeding but consult your doctor immediately if you notice side effects in the baby like excessive sleepiness, skin reactions, or yellowing of the skin or eyes.
• Zeptol CR 200 Tablet 10's may cause drowsiness and dizziness, so avoid driving or operating heavy machinery if you are not alert.
• Do not administer Zeptol CR 200 Tablet 10's to individuals below 18 years of age unless prescribed by the doctor.
• Avoid consuming alcohol while taking Zeptol CR 200 Tablet 10's as it may increase dizziness and sleepiness.
• Consult your doctor immediately if you experience suicidal tendencies or mood swings.

Always follow your doctor's advice and inform them about your medical history and any other medications you are taking before starting Zeptol CR 200 Tablet 10's to ensure safe and effective use.

✔️ Storage Conditions

Store in a cool and dry place below 30°C away from direct sunlight. Keep it out of reach of children and pets.