Valex 100ml - ePharma
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Valex Syrup 100ml

Generic: Sodium Valproate

Type: Syrup

Pack Size: 100ml

Syrup, Generic Name: Sodium Valproate, Manufacturer: Incepta Pharmaceuticals Ltd.


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Description:

Indications

Valex is indicated for the treatment of all types of epilepsy, e.g. Partial seizures, Absence seizures (petit mal), Generalized tonic-clonic seizures (grand mal), Myoclonic seizures, Atonic seizures, Mixed seizures that include absence attack, Prophylaxis of febrile convulsion, Prophylaxis of post-traumatic epilepsy. It is also indicated in the treatment of bipolar disorder & prophylaxis of migraine.

 

Pharmacology

The primary component in this formulation, sodium valproate, has anti-epileptic properties and can be used to treat a variety of seizures. The mechanism through which Sodium Valproate works as an anti-epileptic has yet to be discovered. However, it has been proposed that its action is linked to increased gamma-aminobutyric acid levels in the brain (GABA).

 

Dosage & Administration

Sodium Valproate tablets may be given once or twice daily. Sodium Valproate syrup should be given in divided doses.

Epilepsy-

Adults: Initially 600 mg daily given in 2 divided doses, preferably after food, increasing by 200 mg/day at 3-day intervals to a maximum of 2.5 g daily in divided doses until control of seizure is achieved. Usual maintenance dose is 1-2 g daily (20-30 mg/kg daily)

Children (up to 20 kg): Initially 20 mg/kg daily in divided doses, may be increased provided plasma concentrations monitored (above 40 mg/kg daily also monitor clinical chemistry and hematological parameters).

Children (over 20 kg): Initially 400 mg daily in divided doses increased until control (usually in the range of 20-30 mg/kg daily) Maximum 35 mg/kg daily.

Febrile convulsion: 20-30 mg/kg/day in 3 divided doses.

Bipolar disorder: Initially 20-30 mg/kg/day in 2-3 divided doses; adjust dosage in 3-5 days. Maintenance dosage is 1000-2000 mg/day.

Prophylaxis of migraine: 300 mg twice daily, although some may require 1000 mg daily.

 

Interaction

Sodium vaiproate appears to impede drug metabolism in a non-specific manner. Phenobarbital, Phenytoin, Warfarin, Aspirin, and other drugs with which it interacts the most are Phenobarbital, Phenytoin, Warfarin, and Aspirin.

 

Contraindications

Patients with documented hypersensitivity to the medication as well as liver disease should avoid sodium valproate. Sodium Valproate is not recommended for use during pregnancy or in women who may become pregnant.

 

Side Effect

Anorexia, nausea, and vomiting are the most prevalent adverse effects. The usage of enteric coated pills, on the other hand, reduces these adverse effects. Sedation, ataxia, and tremor are all CNS side effects. These symptoms are uncommon and usually respond to a dose reduction. Rash, baldness, and hunger stimulation have all been reported on occasion. Sodium vaiproate has a number of impacts on hepatic function, including an increase in liver enzymes in plasma in up to 40% of patients, which frequently happens asymptomatically during the first few months of treatment.

 

Pregnancy & Lactation

Sodium vaiproate passes the placenta, and in humans, first-trimester valproate exposure has been linked to neural tube abnormalities including anencephaly and spina bifida in newborns. Pregnant women using Sodium Vaiproate should have their blood a-fetoprotein levels measured. Breast milk excretes sodium valproate. Breast-feeding by a mother taking Sodium Valproate, on the other hand, is unlikely to harm the kid.

 

Precautions & Warnings

Liver function should be checked before starting treatment and during the first six months, especially in individuals who are most at risk. Before beginning and before major surgery, there must be no unnecessary risk of bleeding. Renal impairment, pregnancy, breast-feeding, and systemic lupus erythematosus all require caution. Because sodium valproate is partly removed in the urine as a ketone metabolite, the urine ketone test may be misinterpreted. The abrupt cessation of therapy should be avoided. Sodium Valproate should not be taken during pregnancy or by women who are planning to have children.

 

Therapeutic Class

Primary anti-epileptic drugs

 

Storage Conditions

Store in a cool and dry place, below 30 °C and keep away from light.

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Check our pricing section for Valex Syrup 100ml price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

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