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Diphedan 100 | 1 Strip
Phenytoin stabilizes neuronal membranes by modulating sodium ion movement during nerve impulse generation in the motor cortex. This mechanism:
- Anticonvulsant Effect: Reduces seizure activity by decreasing neuronal excitability.
- Antiarrhythmic Effect: Extends the refractory period and suppresses ventricular pacemaker automaticity, thus stabilizing cardiac rhythm.
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বাহিরে
✅ Description:
Phenytoin – an anticonvulsant and antiarrhythmic agent.
- Status Epilepticus (Grand Mal Type): Effective in the treatment of prolonged seizures.
- Seizure Prevention During Neurosurgery: Used prophylactically in patients undergoing brain surgery.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Uses of Diphedan 100
- Epilepsy/Seizures
✔️ How does Diphedan 100 work?
Diphedan is an antiepileptic medication. It controls seizures or fits by decreasing the abnormal and excessive activity of the nerve cells in the brain.
✔️ Dosage and Administration
For Adults:
- Usual Dose:
- Initial: 200 mg daily (2 tablets).
- Maintenance: 300–400 mg/day (maximum of 600 mg/day) in divided doses.
- For Naive Patients: 1 tablet (100 mg) three times daily or as directed by a physician.
For Children:
- Initial Dose: 5 mg/kg per day, divided into 2–3 doses.
- Maintenance Dose: 4–8 mg/kg per day (maximum: 300 mg daily).
- Children Over 6 Years: Require the minimum adult dose (300 mg/day).
✔️ Side Effects of Diphedan 100
Common:
- Skin rashes (disappear after discontinuation).
- Insomnia, dizziness, slurred speech, headache, transient nervousness.
Serious:
- Hyperglycemia due to inhibition of insulin release.
✔️ Drug Interactions
Phenytoin exhibits extensive interactions:
Potentiation:
- Enhances toxic effects of paracetamol and lithium.
- Effects may be increased with other sedatives or alcohol.
Increased Serum Levels:
- With drugs like cimetidine, omeprazole, fluconazole, methylphenidate, and SSRIs.
Decreased Serum Levels:
- With carbamazepine, rifampin, ciprofloxacin, and folic acid.
Specific Notable Interactions:
- Valproic Acid: May displace phenytoin from protein-binding sites, altering its serum concentration.
- Warfarin: Initial increase in anticoagulation effects, followed by inhibition.
✔️ Contraindications
Known hypersensitivity to Phenytoin or other hydantoins.
✔️ Precautions & Warnings
Skin Reactions:
- Discontinue use if a rash develops.
Long-Term Use:
- Regular blood tests are advised during prolonged therapy.
Pregnancy and Nursing Mothers:
- Use with caution due to potential effects on fetal and infant health.
Hyperglycemia Risk:
- Monitor blood sugar levels, especially in diabetic patients.
✔️ Storage Conditions
- Store below 30°C, protected from light and moisture.
- Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
