Verospiron 25mg Tablet

Uses of Verospiron 25mg Tablet

• Heart failure
• High blood pressure (hypertension)
• Edema (swelling) caused by various conditions
• Treatment of low potassium levels in the body (hypokalemia)

How does Verospiron 25mg Tablet work?

Verospiron is a potassium-sparing diuretic that lowers blood pressure and reduces swelling by eliminating excess water and electrolytes without causing potassium loss.

Side Effects of Verospiron 25mg Tablet

Nausea, Vomiting, Leg cramps, Dizziness, Drowsiness, Confusion, Breast enlargement in males, Increased creatinine level in blood.

Quick Suggestions:

• May cause dizziness initially; avoid activities requiring concentration.
• May increase potassium levels; avoid potassium supplements and potassium-rich foods.
• Regularly monitor kidney function, potassium levels, and blood pressure.
• Report dizziness, diarrhea, vomiting, swelling in feet, or difficulty breathing to the doctor.

Indication

Hypertension, Edema, Hypokalemia, Hepatic cirrhosis with ascites and edema, Hyperaldosteronism, Severe congestive heart failure.

Pharmacology

• Spironolactone, the active ingredient, is a specific pharmacologic antagonist of aldosterone.
• Acts by binding to receptors at the aldosterone-dependent sodium-potassium exchange site.
• Causes increased sodium and water excretion while retaining potassium.

Dosage & Administration:

• Varied dosages based on the specific condition being treated.
• Adjustments may be made according to the patient's response.
• Regular monitoring of kidney function and potassium levels is essential.
• Should be taken with food. Taking it early in the day can reduce the need to wake up at night for frequent urination.

Interaction

• ACE inhibitors: Concomitant use may lead to severe hyperkalemia.
• Alcohol, barbiturates, or narcotics: Potentiation of orthostatic hypotension may occur.
• Corticosteroids, ACTH: Intensified electrolyte depletion, particularly hypokalemia, may occur.
• Lithium: High risk of lithium toxicity.
• Digoxin: Verospiron increases the half-life of digoxin.

Contraindications

Anuria, Hyperkalemia, Acute or progressive renal insufficiency, Addison's disease.

Pregnancy & Lactation

Use in pregnancy and lactation requires careful consideration of potential benefits versus risks.

Precautions & Warnings

• Patients with kidney problems or difficulty urinating should use Verospiron with caution.
• Lifestyle changes like exercise and a low-salt diet may enhance its effectiveness.
• Avoid alcohol consumption.
• Inform the doctor about kidney, liver, or heart diseases, pregnancy, or other medications being used.
• Pregnant or breastfeeding women should consult their doctor.

Storage Conditions

• Store in a cool and dry place protected from light.
• Keep out of reach of children.