Diazepam is indicated for the short-term treatment of mild to moderate anxiety, excitation, agitation, fear, aggressiveness, etc. Anxiety reactions caused by stressed conditions, anxiety states with somatic expression, acute alcohol withdrawal, status epilepticus, premedication for surgical procedures, febrile convulsions, and insomnia of hospitalized patients.
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Seduxen 5 mg is indicated for the short-term treatment of mild to moderate anxiety, excitation, agitation, fear, and aggressiveness. It is also used for anxiety reactions caused by stressful conditions, anxiety states with somatic expression, acute alcohol withdrawal, status epilepticus, premedication for surgical procedures, febrile convulsions, and insomnia in hospitalized patients.
Seduxen 5 mg belongs to the drug classes of benzodiazepine sedatives, centrally acting skeletal muscle relaxants, and primary anti-epileptic drugs. It attaches to specific sites on the GABA receptor, potentiating the effect of GABA, and leading to the opening of chloride ion channels into cells.
Seduxen 5 mg binds to receptors in various regions of the brain, potentiating the inhibitory actions of gamma-aminobutyric acid (GABA) mediated through chloride channels. This enhances GABA-facilitated, inhibitory synaptic transmission.
Common side effects of Seduxen 5 mg include somnolence, dizziness, lightheadedness, confusion, and ataxia. Higher doses may exacerbate these effects.
Dosage should be individualized for maximum benefit. For adults, the usual daily dosage ranges from 2 mg to 10 mg, 2 to 4 times daily depending on the severity of symptoms. Pediatric patients should start with the lowest effective dose and increase gradually. Dosage adjustments are required for geriatric patients and those with debilitating diseases.
Overdose may lead to symptoms such as sedation, muscle weakness, profound sleep, or paradoxical excitation. Severe cases may present with ataxia, hypotonia, hypotension, respiratory depression, coma, and rarely death.
Concomitant use of Seduxen 5 mg with alcohol is not recommended. Sedation may increase with concomitant use of neuroleptics, hypnotics, sedative antihistamines, CNS depressants, general anesthetics, narcotic analgesics, or antidepressants. Pharmacokinetic interactions may occur with phenobarbitone, cimetidine, omeprazole, and isoniazid.
Seduxen 5 mg is contraindicated in patients with myasthenia gravis, pulmonary insufficiency, respiratory depression, and hypersensitivity to benzodiazepines.
The use of Seduxen 5 mg during the first trimester of pregnancy should be avoided due to the risk of congenital malformations. It is detected in breast milk, so its use should be avoided during lactation if possible.
Prolonged use and abrupt withdrawal of Seduxen 5 mg should be avoided. Caution is advised in patients with respiratory disease, muscle weakness, a history of drug or alcohol abuse, and hepatic or renal impairment.
Seduxen 5 mg should be stored in a cool and dry place protected from light, preferably below 25°C temperature.
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