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Barbit 30mg Tablet, also known as phenobarbitone or phenobarbital, is used to treat various types of seizures except for absence seizures. It can also be used to manage epilepsy, insomnia, and drug withdrawal symptoms.
Barbit 30mg Tablet works by affecting GABA receptors in the brain, leading to the production of GABA, an amino acid that reduces neuron excitability. However, there is a potential for drug dependency, and sudden cessation may lead to withdrawal symptoms, including status epilepticus in epileptic patients.
The drug is not recommended for patients with porphyria, hypersensitivity or allergy to barbiturates, respiratory insufficiency, hyperkinesia, liver cell deterioration, and other liver problems. Caution should be exercised when using it with certain drugs like aceprometazine and adipilon.
Common side effects of Barbit 30mg Tablet include drowsiness, excitation, irritability, loss of balance or coordination, headache, loss of appetite, nausea, vomiting, and constipation. More severe side effects such as insomnia, hypoventilation, apnea, hypotension, and syncope may also occur, requiring medical attention. Therefore, it is essential to consult a doctor to determine the appropriate dosage and avoid unwanted and severe side effects.
In case of overdose, symptoms may include unsteady gait, slurred speech, confusion, jaundice, hypothermia, hypotension, respiratory depression, and coma. If hypotension occurs, intravenous fluids and positioning the patient in the Trendelenburg position may be necessary. In severe cases, an intravenous vasopressor (e.g., dopamine, epinephrine) might be required.
Activated charcoal can be used to reduce the half-life of phenobarbital through nonrenal elimination. Adequate hydration and renal function should be ensured. Urinary alkalinization with intravenous sodium bicarbonate can also enhance elimination. Hemodialysis or hemoperfusion may be considered for patients in stage IV coma due to high serum barbiturate levels.
It is unsafe to consume alcohol with Barbit 30mg Tablet.
Barbit 30mg Tablet is not recommended for use during pregnancy due to the potential risk to the fetus. However, in certain life-threatening situations, the benefits of using the medication may outweigh the risks. Please consult your doctor for further guidance.
Not recommended for breastfeeding women unless essential. Discuss risks and benefits with the doctor. Breastfeeding may need to be discontinued or drug use stopped based on your condition. Consult your doctor.
May cause blurred vision or dizziness. Avoid driving or operating machinery if these symptoms occur during treatment.
There is no data available. Please consult the doctor before consuming the drug.
There is no data available. Please consult a doctor before consuming the drug.
This medication works by affecting GABA receptors. The drug facilitates the production of GABA (Gamma AminoButyric Acid) an amino acid that helps in reducing the excitability of neurons.
The uses of Barbit 30mg Tablet include:
Phenobarbital is a long-acting barbiturate that works by depressing the sensory cortex, reducing motor activity, and changing cerebellar function, leading to drowsiness, sedation, and hypnosis. It acts on GABAA receptors to increase synaptic inhibition, elevating the seizure threshold and reducing seizure activity. Additionally, it may inhibit calcium channels, decreasing excitatory transmitter release. The sedative and hypnotic effects are likely due to its impact on the polysynaptic midbrain reticular formation, which controls CNS arousal.
Adult Dose:
Child Dose:
12 years: 1-3 mg/kg/day in 1-2 divided doses, OR 50-100 mg BID/TID.
Renal Dose:
Administration:
Phenobarbital may interact with several medications and substances, leading to potential effects on their levels and actions. Some notable interactions include:
It is crucial for patients and healthcare professionals to be aware of these interactions and adjust treatment plans accordingly to avoid adverse effects or reduced efficacy of medications. Always consult a healthcare provider before starting or stopping any medications or substances while taking phenobarbital.
Barbit 30mg Tablet should not be used in individuals with these conditions as it may cause adverse effects or worsen the existing health conditions. Pregnant women should avoid using this medication due to potential risks to the unborn baby. It is important to consult a healthcare professional before starting or stopping any medication.
Phenobarbital is classified as Pregnancy Category D, which means it has the potential to cause fetal harm when used during pregnancy. The drug, either used alone or in combination with other anticonvulsants, may lead to coagulation defects in the newborn infant. This effect can be prevented by giving the mother prophylactic Vitamin K before delivery.
Furthermore, phenobarbital is excreted in human breast milk, so caution should be exercised when using the medication during the lactation period. The potential risk to the nursing infant should be carefully weighed against the benefits of using phenobarbital in lactating mothers. It is essential for pregnant or breastfeeding women to consult their healthcare provider before using phenobarbital or any other medications to ensure the safety of both the mother and the child.
Phenobarbital should be used with caution and under the supervision of a healthcare professional in the following conditions:
Patients should be aware that phenobarbital may impair their ability to drive or operate machinery. Regular monitoring of complete blood count (CBC), liver function tests (LFTs), mental status, and seizure activity may be necessary during treatment. For lactating women, nursing should be avoided while using phenobarbital. It is essential to discuss any medical history or concerns with the prescribing healthcare professional. Abrupt withdrawal from the medication should also be avoided
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
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