Spotclen 4% Cream

Uses of Spotclen 4% Cream

• Melasma
• Hyperpigmentation
• Dark spots
• Photoaging (premature aging of the skin caused by repeated exposure to UV radiation)

How does Spotclen 4% Cream work?

Hydroquinone suppresses melanocyte metabolic processes, increases melanin excretion from melanocytes, and prevents melanin production.

Side Effects of Spotclen 4% Cream

Mild skin irritation, sensitization, dryness, fissuring, ochronosis, and colloid milium (after chronic use of up to 8 years).

Quick Suggestions:

• Use Spotclen along with sun-avoidance measures such as sunscreen and protective clothing.
• Apply a thin layer to the affected area/lesion.
• Avoid contact with eyes or mouth; rinse with water if it happens.
• Use as prescribed by your doctor with regular follow-up.
• Test for allergic reactions by applying a small amount to a patch of skin. Continue if there's no allergic reaction.
• Do not use on broken or infected skin.

Indications:

Hydroquinone is recommended for the progressive bleaching of hyperpigmented skin disorders such as chloasma, melasma, freckles, senile lentigines, and other regions of unwanted melanin hyperpigmentation. It also reduces hyperpigmentation induced by photosensitization caused by inflammation or the use of certain cosmetics.

Pharmacology

Hydroquinone is a topical depigmenting drug that inhibits the enzymatic oxidation of tyrosine to 3,4-dihydroxyphenylalanine and suppresses melanocyte metabolic processes, leading to reversible skin depigmentation.

Dosage & Administration of Spotclen 4% Cream

Adult Dose:

• Topical/Cutaneous Hyperpigmented skin conditions: Apply and rub in a thin layer preparation to the affected area twice daily.

Child Dose:

• Safety and efficacy in children under 12 years old have not been established.

Administration:

• Apply a thin layer of Hydroquinone Cream to the affected area once daily, at least 30 minutes before bedtime.
• Gently cleanse the face and neck with a mild cleanser, rinse, and pat the skin dry.
• Apply Hydroquinone Cream to the hyperpigmented areas of melasma, including about ½ inch of normal-appearing skin surrounding each lesion.
• Rub it in lightly and evenly. Discontinue therapy once control is achieved. During the day, use SPF 30 sunscreen and wear protective clothing. Avoid sunlight exposure.
• Moisturizers and/or cosmetics may be used during the day.
• Hydroquinone Cream is for topical use only; do not use it orally, in the eyes, or intravaginally.

Interaction

If you have kidney or liver problems, eczema, and asthma, inform your physician before using Hydroquinone.

Contraindications

Hydroquinone is contraindicated for patients with a prior history of hypersensitivity or allergic reaction to hydroquinone or other ingredients in the preparation.

Pregnancy & Lactation

 Pregnancy Classification C. Animal studies have indicated negative effects on the fetus (teratogenic, embryocidal, or other), and no controlled studies in women have been conducted. Drugs should be administered only if the potential benefit outweighs the risk to the fetus. It is unknown if topical hydroquinone is absorbed or eliminated in human milk during lactation, so caution is suggested when a nursing mother uses it.

Precautions & Warnings

Hydroquinone is a skin whitening agent, and if not used as directed, it can produce unwanted cosmetic effects. Doctors must be familiar with the contents of this manual before prescribing or dispensing the medication. Test skin sensitivity before use by applying a small amount to a small area of skin and checking for a reaction within 24 hours. Mild redness is not a contraindication, but if itching, blistering, or excessive inflammation occurs, further treatment is not recommended. If no whitening or lightening effect is observed after 2 months of treatment, discontinue the drug. Avoid contact with eyes and lips, and do not use on cut or bruised skin.

Storage Conditions

Store between 20-25°C and protect from light.