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Valex CR 500mg Tablet (Box)
Valex CR is indicated for the treatment of various forms of epilepsy, including:
- Partial seizures
- Absence seizures (petit mal)
- Generalized tonic-clonic seizures (grand mal)
- Myoclonic and atonic seizures
- Mixed seizure types involving absence episodes
- Prevention of febrile seizures
- Prevention of post-traumatic epilepsy
Additionally, Valex CR is used in managing bipolar disorder and for migraine prophylaxis.
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✅ Description:
Sodium Valproate exerts broad-spectrum antiepileptic action. Although its exact mechanism is not fully defined, it is thought to enhance gamma-aminobutyric acid (GABA) levels in the brain, contributing to its anticonvulsant properties.
Injection:
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Side Effects
- GI disturbances (anorexia, nausea, vomiting) — minimized with enteric-coated tablets
- CNS effects: sedation, tremor, ataxia — dose-dependent
Occasional: - Rash, hair thinning, increased appetite
- Elevated liver enzymes in ~40% of patients (often transient)
Serious (rare): - Fulminant hepatitis, especially in young children or those on multiple AEDs
- Acute pancreatitis
- Hyperammonemia
✔️ Dosage & Administration
Epilepsy
- Adults: Start with 600 mg/day in 2 doses, increasing by 200 mg/day every 3 days up to 2.5 g/day as needed. Usual maintenance: 1–2 g/day (20–30 mg/kg/day).
- Children >20 kg: Begin at 400 mg/day in divided doses; adjust up to 35 mg/kg/day.
- Children <20 kg: Initiate at 20 mg/kg/day in divided doses.
Febrile Seizures: 20–30 mg/kg/day in 3 doses.
Bipolar Disorder: Begin with 600 mg/day (20–30 mg/kg/day) in 2–3 doses; maintenance: 1000–2000 mg/day.
Migraine Prophylaxis: Usually 400–600 mg/day; some may need 1000–1500 mg/day.
✔️ Drug Interactions
Sodium Valproate can inhibit hepatic drug metabolism, notably interacting with:
- Phenobarbital
- Phenytoin
- Warfarin
- Aspirin
✔️ Contraindications
- Known hypersensitivity to sodium valproate
- Liver dysfunction
- Use is restricted during pregnancy and in women of childbearing potential
✔️ Use in Pregnancy & Lactation
- Crosses pthe lacenta; first trimester exposure linked to neural tube defects (e.g., spina bifida)
- Monitor maternal serum alpha-fetoprotein during pregnancy
- Excreted in breast milk, though considered relatively safe for breastfeeding infants
✔️ Precautions & Warnings
- Monitor liver function before initiation and regularly during the first 6 months, particularly in high-risk patients
- Ensure no bleeding risk before initiating or performing major surgery
- Caution in renal impairment, pregnancy, lactation, and lupus
- May cause false-positive urine ketone tests
- Do not abruptly discontinue therapy
- Contraindicated during pregnancy and in women with reproductive potential
✔️ Storage
Store below 30°C. Protect from light and keep out of reach of children.
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