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Gabapentin is an anticonvulsant medication, structurally similar to gamma-aminobutyric acid (GABA). Its pharmacological effects arise from its interaction with the alpha-2-delta subunit of voltage-gated L-type calcium channels, which helps inhibit the release of excitatory neurotransmitters by affecting amino acid transferases.
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✅ Description:
Safety Advices
Alcohol
UNSAFE
It is not safe to consume alcohol while taking Gabapentin, as it may exacerbate side effects such as dizziness and drowsiness.
Pregnancy
CONSULT YOUR DOCTOR
Gabapentin is classified as a category B1 pregnancy drug. Consult your doctor to evaluate the benefits and potential risks before prescribing Gabapentin.
Breastfeeding
CONSULT YOUR DOCTOR
Generally, it is possible to breastfeed while taking Gabapentin. However, consult your doctor before starting the medication to discuss the benefits and potential risks.
Driving
UNSAFE
Avoid driving or operating machinery if you experience dizziness, drowsiness, or visual disturbances (such as blurry or double vision) while using Gabapentin. Seek medical attention if these symptoms persist.
Kidney
CONSULT YOUR DOCTOR
Use Gabapentin with caution if you have a history of kidney disease or conditions. Dose adjustments may be necessary, and your doctor will assess this based on your medical history.
Liver
CONSULT YOUR DOCTOR
Use Gabapentin with caution if you have a history of liver disease or conditions. Your doctor may need to adjust your dose accordingly.
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✔️ Indications: Adjunct anti-epileptic drugs
- Neuropathic Pain
- Adjunctive therapy in partial seizure and secondary generalized seizure
✔️ Dosage: Gabapen 300
Neuropathic Pain:
- Day 1: Initiate treatment with a single dose of 300 mg.
- Day 2: Increase to 300 mg twice daily.
- Day 3: Increase to 300 mg three times daily.
- After Day 3, titrate up to a maximum of 1800 mg daily (divided into three doses) as needed for pain relief.
Epilepsy:
- Patients over 12 years: Effective daily dose ranges from 900 mg to 1800 mg, administered in three divided doses, starting with 300 mg three times a day.
- Pediatric patients (ages 3-12): Starting dose of 10-15 mg/kg/day in three divided doses, titrated upward over approximately three days.
Administration: Gabapentin can be taken orally, with or without food.
✔️ Side Effects: Possible side effects include:
- Fatigue
- Dizziness
- Ataxia
- Weight gain
- Peripheral edema
- Dry mouth
- Somnolence
✔️ Interactions: Gabapen 300
- Antacids may decrease the bioavailability of Gabapentin by up to 20%.
- Cimetidine may affect its renal excretion.
- Gabapentin does not interact with other antiepileptic drugs or oral contraceptives.
✔️ Contraindications:
Known hypersensitivity to Gabapentin.
✔️ Pregnancy & Lactation:
- Pregnancy Category C: Gabapentin should only be used during pregnancy if the potential benefits justify the risks to the fetus.
- Gabapentin may be excreted in breast milk; use during lactation should be considered only if the benefits outweigh the risks.
✔️ Precautions & Warnings:
- Patients should take Gabapentin only as prescribed.
- Caution is advised when driving or operating machinery until the effects of the medication are known.
✔️ Use in Special Populations:
- Dosage adjustments are necessary for patients with renal impairment.
✔️ Storage Conditions:
- Store below 25°C, and protect from light and moisture. Keep out of reach of children.
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lab tests, medicines, all possible side effects, drug interactions,
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