Pendoril 4mg Tablet 10pcs

✔️ Uses of Pendoril 4mg Tablet

• Hypertension (high blood pressure)
• Prevention of heart attack and stroke
• Heart failure

✔️ How does Pendoril 4mg Tablet work?

Perindopril is an ACE inhibitor, blocking the action of angiotensin-converting enzyme (ACE). This leads to a reduction in angiotensin II production, allowing blood vessels to relax and widen, resulting in a drop in blood pressure.

✔️ Side Effects of Pendoril 4mg Tablet

• Rare and Mild: Cough, fatigue, asthenia, headache, disturbances of mood and/or sleep.
• Less Often: Taste impairment, epigastric discomfort, nausea, abdominal pain, and rash.
• Reversible Increase: Blood urea and creatinine.
• Proteinuria: Occurred in some patients.
• Rarely: Angioneurotic edema, decrease in hemoglobin, red cells, and platelets.

✔️ Quick Suggestions:

• Rise slowly due to initial dizziness.
• Report persistent cough or throat irritation.
• Avoid potassium supplements and rich foods.
• Inform the doctor if pregnant, planning pregnancy, or breastfeeding.

✔️ Indication of Pendoril 4mg Tablet

• High blood pressure (hypertension)
• Heart failure
• Post-heart attack therapy to reduce the risk of future strokes and heart attacks

✔️ Pharmacology

Perindopril, a long-acting ACE inhibitor, is indicated in essential hypertension, stable coronary artery disease, and congestive heart failure.

✔️ Dosage & Administration of Pendoril 4mg Tablet

• Hypertension: One Perindopril 4 tablets once daily in the morning. The dose may be increased to 8 mg after 1 month if necessary.
• Stable Coronary Artery Disease: Perindopril 4 once daily for two weeks, then increased to 8 mg once daily. Elderly patients may start with 2 mg and titrate.
• Congestive Heart Failure: Start with 2 mg in the morning, may increase to 4 mg if necessary. Caution in elderly patients, start at a low daily dose.

✔️ Interaction

• May enhance the hypotensive effect with diuretics.
• Additive hyperkalaemic effect with K supplements, K-sparing diuretics, and other drugs.
• Increased serum levels and toxicity of lithium.
• Antihypertensive effects may be reduced by aspirin or other NSAIDs.
• Coadministration with NSAIDs may increase the risk of renal impairment.
• Increased risk of hypoglycemia with antidiabetic agents.
• Rare nitritoid reactions with concomitant use of gold (Na aurothiomalate).

✔️ Contraindications

• Hypersensitivity to Perindopril.
• Contraindicated in children, during pregnancy, and lactation.

✔️ Pregnancy & Lactation

Perindopril should not be used during pregnancy and lactation.

✔️ Precautions & Warnings:

• Use with caution in renovascular hypertension, surgery/anesthesia, and renal failure.
• Adjust the dose cautiously per creatinine clearance.
• Symptomatic hypotension is rare but more likely in volume-depleted patients.
• Stop diuretic 3 days before starting Perindopril in diuretic-treated patients.

✔️ Storage Conditions

• Keep below 30°C temperature, away from light and moisture.
• Keep out of the reach of children.