Losartan Potassium-
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Consumption of alcohol with Osartil 50mg Tablet may increase the risk of low blood pressure and cause adverse effects such as dizziness, fainting, light-headedness, or headache.
Osartil 50mg Tablet is unsafe for use during pregnancy as it can cause harm to your developing fetus.
Osartil 50mg Tablet is not recommended during breastfeeding. It is advisable to consult a doctor to find a safer alternative.
Avoid driving vehicles or operating machines if you feel dizzy or drowsy after taking Osartil 50mg Tablet.
Osartil 50mg Tablet should be given with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.
Osartil 50mg Tablet should be given with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.
Osartil 50mg Tablet blocks the action of a chemical messenger that causes the narrowing of the blood vessels. Hence, it relaxes the blood vessels and allows the blood to flow easily, thus lowering blood pressure.
Osartil 50mg Tablet is used to lower high blood pressure and protect the kidneys from diabetes. It reduces the risk of stroke by relaxing blood vessels and lowering blood pressure.
Losartan Potassium is an angiotensin II receptor blocker (ARB) and belongs to a class of medications that inhibit the action of angiotensin II on its receptors. Unlike previous ARBs, Losartan Potassium is not a peptide but a non-peptide compound. It selectively binds to the angiotensin II type 1 (AT1) receptor, which is found in various tissues, including vascular smooth muscle, the adrenal glands, the kidneys, and the heart.
By blocking the AT1 receptor, Losartan Potassium prevents the binding of angiotensin II and inhibits its vasoconstrictive effects. This leads to relaxation of the blood vessels, resulting in vasodilation and a decrease in blood pressure. Additionally, Losartan Potassium reduces the production and release of aldosterone, a hormone that promotes sodium and water retention, thereby further contributing to its antihypertensive effects.
Overall, Losartan Potassium helps to lower blood pressure and is used in the treatment of hypertension (high blood pressure) and certain conditions related to the heart and blood vessels. It is important to take Losartan Potassium as prescribed by a healthcare professional and to follow their instructions for optimal therapeutic benefits.
The usual starting and maintenance dose for most patients is 50 mg once daily. If the desired antihypertensive effect is not achieved with 50 mg once daily, a dose of 25 mg twice daily may be considered before increasing the dose further.
For patients who are intravascular volume-depleted, such as those receiving high-dose diuretics, a lower starting dose of 25 mg once daily is recommended.
The total daily dose of Losartan Potassium can range from 25 mg to 100 mg, depending on the individual patient's response and the prescribing physician's judgment. The dose can be administered once daily or divided into two doses taken twice daily.
Rifampicin and fluconazole can reduce the levels of the active metabolite of Losartan Potassium. It is important to inform your doctor if you are taking these medications concurrently with Losartan Potassium.
Concurrent use of Losartan Potassium with hydrochlorothiazide, a diuretic, may result in an enhanced antihypertensive effect. This combination should be used with caution and under the guidance of a healthcare professional.
Concurrent use of Losartan Potassium with potassium-sparing diuretics (such as spironolactone, triamterene, amiloride), potassium supplements, or potassium-containing salt substitutes may lead to an increase in serum potassium levels. Regular monitoring of potassium levels is recommended in such cases.
The nonsteroidal anti-inflammatory drug indomethacin may reduce the antihypertensive effect of Losartan Potassium. If you are taking indomethacin or any other nonsteroidal anti-inflammatory drug, it is important to inform your doctor.
Concurrent use of an ACE inhibitor (angiotensin-converting enzyme inhibitor), an angiotensin receptor antagonist (such as Losartan Potassium), an anti-inflammatory medication, and a thiazide diuretic can increase the risk of renal impairment. Close monitoring of renal function is necessary when using these medications together.
Losartan Potassium is not recommended for use in pregnant women due to the potential risk of harm to the unborn baby (fetus). It is important for pregnant women to consult with their healthcare provider for alternative treatment options.
Additionally, Losartan Potassium should not be used in individuals who are allergic to any of its components.
In diabetic individuals, the use of Losartan Potassium with Aliskiren, another medication used to treat high blood pressure, is generally not recommended. This combination may increase the risk of certain side effects, including low blood pressure, high potassium levels, and changes in kidney function. It is important to inform your healthcare provider about all medications you are taking, including any over-the-counter drugs or supplements, to ensure safe and effective treatment.
Losartan Potassium is actually classified as Pregnancy Category D in the second and third trimesters and Pregnancy Category C in the first trimester.
Pregnancy Category D means that there is positive evidence of fetal risk based on human data, but the potential benefits of the medication may outweigh the risks in certain situations. Losartan Potassium should generally be avoided during the second and third trimesters of pregnancy due to the risk of harm to the unborn baby, including reduced kidney function, low amniotic fluid levels, developmental abnormalities, and even death.
In the first trimester, Losartan Potassium is classified as Pregnancy Category C, which means that there are no well-controlled studies on pregnant women, and the potential benefits and risks should be carefully considered before using the medication during this period.
Regarding breastfeeding, it is unknown if Losartan Potassium is excreted in human milk. However, many medications are known to be excreted in breast milk. Therefore, a decision should be made whether to discontinue breastfeeding or discontinue the use of Losartan Potassium, taking into consideration the importance of the medication for the mother's health.
It is important to consult with a healthcare professional, such as your doctor or obstetrician, if you are pregnant or planning to become pregnant, as they can provide the most appropriate guidance regarding the use of Losartan Potassium or alternative medications for your specific situation.
Keep away from light and heat in a dry area. Keep out of children's reach.
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