Antigall 150 Tablet 1 Strip

✔️ Antigall 150 is used for:

• Primary Biliary Cirrhosis (PBC)
• Dissolution of cholesterol-rich gallstones in patients with a functioning gallbladder
• Prevention of gallstone formation in selected patients undergoing rapid weight loss
• Liver and biliary disease associated with cystic fibrosis in children aged 6 to less than 18 years, when prescribed by a physician

✔️ Depending on the indication, your doctor may monitor:

• Liver function tests (LFTs)
• Bilirubin levels
• Gallbladder and gallstone status through ultrasound or other imaging
• Treatment response
• Occurrence of diarrhea or other adverse effects

✔️ Words of Advice:

• Take Antigall 150 with or after food as directed by your doctor.
• Swallow the tablet whole with water or milk.
• Follow a healthy, balanced diet and avoid excessive dietary cholesterol and calories.
• Drink plenty of fluids if diarrhea occurs.
• Inform your doctor if diarrhea persists or if blood appears in the stool.
• Regular liver function tests and bilirubin monitoring may be required.
• Ultrasound examinations may be performed to monitor gallstones during treatment.
• Continue the medicine for the full duration prescribed, even if symptoms improve.
• Do not stop treatment without consulting your doctor.
• Women taking Antigall 150 specifically for gallstone dissolution should discuss their contraceptive method with their doctor, as estrogen-containing contraceptives may increase biliary cholesterol and potentially promote gallstone formation.

✔️ Drug Interactions

Tell your doctor about all medicines and supplements you are taking. Ursodeoxycholic Acid may interact with:

• Cholestyramine, colestipol, activated charcoal, and certain antacids: May reduce the absorption and effectiveness of Ursodeoxycholic Acid.
• Aluminium-containing antacids: May reduce its absorption.
• Oral contraceptives and estrogenic hormones: May increase cholesterol secretion into bile and potentially counteract the effect of Ursodeoxycholic Acid when used to dissolve gallstones.
• Clofibrate: May increase biliary cholesterol and potentially reduce the effectiveness of gallstone-dissolving treatment.
• Ciclosporin: Ursodeoxycholic Acid may increase ciclosporin concentrations in the blood.
• Dapsone: Its therapeutic effect may be reduced.
• Ciprofloxacin: Ursodeoxycholic Acid may reduce ciprofloxacin concentrations in some cases.
• Nitrendipine: Its plasma concentration and therapeutic effect may be reduced.

✔️ Antigall 150 should not be used in patients with:

• Known allergy or hypersensitivity to Ursodeoxycholic Acid or any component of the formulation
• Calcified or radiopaque gallstones
• Acute inflammation of the gallbladder or biliary tract
• Blockage or obstruction of the common bile duct or cystic duct
• Frequent episodes of biliary colic
• Poor or impaired gallbladder contractility
• A non-functioning gallbladder
• Certain inflammatory bowel diseases
• Conditions that interfere with the enterohepatic circulation of bile acids
• Ileal resection or stoma
• Regional ileitis
• Active gastric or duodenal ulcer
• Acute, chronic, or severe liver disease

✔️ Side Effects

• Diarrhea or loose stools
• Abdominal pain or discomfort
• Indigestion
• Nausea or vomiting
• Dizziness
• Headache
• Back pain
• Itching (pruritus)
• Rash
• Hair loss (alopecia)
• Flatulence
• Fatigue

✔️ Directions for Use:

• Take Antigall 150 exactly as prescribed by your doctor.
• Take it with or after food, unless otherwise directed.
• Swallow the tablet whole with a glass of water or milk.
• Do not crush, chew, or break the tablet.
• The appropriate dose depends on your body weight and the condition being treated.
• Take the medicine regularly and complete the prescribed duration of treatment.
• Even if gallstones appear to have dissolved, treatment may need to continue for several weeks or months as advised by your doctor.

✔️ Precautions & Warnings

Antigall 150 should be used cautiously in patients with liver disease.

During treatment:

• Avoid excessive dietary intake of calories and cholesterol.
• Liver function tests and bilirubin levels may need to be monitored regularly.
• Your doctor may recommend monthly monitoring during the first 3 months and periodic monitoring thereafter.
• Ultrasound or other imaging tests may be required to assess gallstones and treatment response.
• Inform your doctor if you experience persistent diarrhea.
• Tell your doctor if you have gallbladder or bile duct inflammation, frequent cramp-like pain in the upper abdomen, or other hepatobiliary problems.
• Do not discontinue treatment without consulting your doctor.

Pregnancy

Antigall 150 should be used during pregnancy only when clearly considered necessary by a doctor. Inform your doctor if you are pregnant, planning to become pregnant, or become pregnant during treatment.

Breastfeeding

It is not fully established whether Ursodeoxycholic Acid passes into human breast milk. Therefore, breastfeeding women should consult their doctor before using Antigall 150.

Use in Children

Antigall 150 may be prescribed for certain liver and biliary conditions in children, including liver disease associated with cystic fibrosis in children aged 6 to less than 18 years. It should only be used in children under medical supervision.

It should not be used in children with certain conditions associated with inadequate bile flow or biliary obstruction unless specifically prescribed by a specialist.

Use in Elderly Patients

Antigall 150 may be used in elderly patients when prescribed by a physician. Dose selection should take the patient's medical condition and other relevant precautions into account.

✔️ Dosage & Administration

Dissolution of Cholesterol-Rich Gallstones

Adults: The usual dose is 8–12 mg/kg/day, taken once daily at bedtime or in 2 divided doses.

Treatment may continue for up to 2 years, depending on the size and response of the gallstones. Treatment is generally continued for several months after radiological disappearance of the stones.

Obese patients: The dose may be increased to 15 mg/kg/day when considered appropriate by the physician.

Primary Biliary Cirrhosis

Adults: 10–16 mg/kg/day, administered in 2–4 divided doses. After the initial treatment period, once-daily evening administration may be considered according to the physician's advice.

Prevention of Gallstones During Rapid Weight Loss

Adults: 300 mg twice daily.

Liver Disease Associated with Cystic Fibrosis

Children aged 6 to less than 18 years: The dose should be determined by the physician according to body weight and clinical condition.

Missed Dose

If you forget to take a dose, take it when you remember unless it is nearly time for your next dose. If it is close to the next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take two doses together to compensate for a missed dose.

✔️ Storage Conditions

Store in a cool, dry place and protect from light. Keep out of the reach of children.