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Stacor 10mg Tablet 1 Strip
Atorvastatin is a selective inhibitor of HMG-CoA reductase, the key enzyme responsible for cholesterol synthesis in the liver. By inhibiting this enzyme, atorvastatin reduces hepatic cholesterol production and increases LDL receptor activity, leading to enhanced clearance of LDL cholesterol from the bloodstream.
Stacor should not be used in patients with:
- Hypersensitivity to atorvastatin or formulation components
- Active liver disease or persistent elevation of liver enzymes
- History of severe adverse reactions to statins
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বাহিরে
100% Genuine Products, Guaranteed
Safe & Secure Payments, Always
Fast, Secure & Efficient Delivery
Proper Packaging
- Cash on Delivery - All over Bangladesh
- Regular Delivery - 12-24 Hours, Dhaka City* Charge Tk.39-59
- Regular Delivery - 24-48 Hours, Other Cities* Charge Tk.99-110
- ফ্রি ডেলিভারিঃ - ৯৯৯ টাকা+ অর্ডারে, ঢাকা
শহরে
- ফ্রি ডেলিভারিঃ - ২৯৯৯ টাকা+ অর্ডারে, ঢাকার
বাহিরে
✅ Description:
Stacor is prescribed as an adjunct to dietary modification and lifestyle changes to manage lipid disorders when non-pharmacological measures alone are insufficient. It is used to:
- Lower total cholesterol, LDL-cholesterol, apolipoprotein B (ApoB), and triglycerides
- Treat heterozygous and homozygous familial hypercholesterolemia
- Manage mixed dyslipidemia (Fredrickson Types IIa and IIb)
- Reduce elevated triglyceride levels in hypertriglyceridemia (Fredrickson Type IV)
- Treat dysbetalipoproteinemia (Fredrickson Type III)
- Reduce the risk of ischemic cardiac events in patients with asymptomatic or mild to moderate coronary artery disease and elevated LDL-cholesterol
- Lower cholesterol levels in patients with diabetes mellitus or following renal transplantation
Absorption
Rapidly absorbed after oral administration
Peak plasma levels achieved within 1–2 hours
Absolute bioavailability of parent drug is approximately 14%
Systemic inhibitory activity reaches about 30%
Distribution
Mean volume of distribution: ~381 L
Approximately 98% protein-bound
Limited penetration into red blood cells
Likely excreted into breast milk based on animal studies
Metabolism
Extensively metabolized into active ortho- and para-hydroxylated metabolites
Metabolism primarily via CYP3A4
Active metabolites contribute approximately 70% of HMG-CoA reductase inhibitory activity
Excretion
Eliminated mainly through bile
Plasma half-life of atorvastatin: ~14 hours
Functional inhibitory half-life: 20–30 hours
Less than 2% excreted unchanged in urine
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Stacor is generally well tolerated. Common adverse effects include:
- Constipation
- Flatulence
- Dyspepsia
- Abdominal discomfort
- Other possible reactions:
- Headache
- Back pain
- Rash
- Muscle or joint pain
- Weakness and fatigue
✔️ Dosage & Administration
Primary Hypercholesterolemia & Mixed Hyperlipidemia
- Adults: Start with 10 mg once daily; may increase every 4 weeks up to 80 mg/day
- Children (10–18 years): Start with 10 mg once daily; usual maximum 20 mg/day
Familial Hypercholesterolemia
- Adults: 10 mg daily initially; titrate up to 40 mg or maximum 80 mg daily if required
- Children (10–18 years): Start with 10 mg daily; titrate as needed up to 80 mg/day
Prevention of Cardiovascular Events
- Adults: Start with 10 mg once daily; adjust based on lipid response
General Guidelines
- Patients should follow a cholesterol-lowering diet before and during treatment
- Dosage range: 10–80 mg once daily
- Can be taken at any time of day, with or without food
- Lipid levels should be reassessed within 2–4 weeks for dose adjustment
Elderly: Higher plasma concentrations; enhanced LDL-C reduction observed
Pediatric patients: Limited pharmacokinetic data available
Renal impairment: No dose adjustment required
Hemodialysis: Clearance not significantly affected
Hepatic impairment: Markedly increased drug exposure in chronic liver disease
✔️ The risk of muscle toxicity increases when Stacor is used with:
- Cyclosporine
- Fibrates
- Niacin
- Erythromycin
- Azole antifungals
Other interactions include:
- Antacids: Reduce atorvastatin levels without affecting LDL reduction
- Colestipol: Lowers atorvastatin concentration but enhances LDL-C reduction
- Digoxin: Increases digoxin plasma levels—monitor closely
- Oral contraceptives: Increases norethindrone and ethinyl estradiol exposure
- Warfarin: No clinically significant effect on anticoagulation
✔️ Pregnancy & Lactation
Pregnancy
Contraindicated during pregnancy
May interfere with fetal cholesterol synthesis
Treatment should be stopped immediately if pregnancy occurs
Lactation
Contraindicated during breastfeeding
Potential risk of serious adverse effects in infants
✔️ Precautions & Warnings
Liver function tests should be performed before starting therapy and periodically thereafter
Use cautiously in patients with alcohol use or liver disease
Discontinue treatment if severe muscle symptoms or significantly elevated CK levels occur
✔️ Storage:
Store in a cool, dry place
Protect from light and heat
Keep out of reach of children
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
