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Tiginor 10mg Tablet 1 Strip
Tiginor (atorvastatin) selectively inhibits the enzyme HMG-CoA reductase, which plays a crucial role in cholesterol production. Blocking this enzyme lowers cholesterol synthesis in the liver and increases LDL receptor activity, enhancing LDL clearance from the bloodstream.
- Absorption: Rapidly absorbed, peaking within 1–2 hours. Bioavailability of the active drug is ~14%, while ethe nzyme inhibition effect is ~30%.
- Distribution: Broadly distributed (volume ~381L); ~98% bound to plasma proteins; limited entry into red blood cells.
- Metabolism: Extensively metabolized by CYP3A4 into active metabolites that significantly contribute to its therapeutic effect.
- Excretion: Mainly eliminated via bile; less than 2% excreted in urine. The drug’s half-life is about 14 hours, but enzyme inhibition lasts 20–30 hours.
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✅ Description:
Tiginor is prescribed alongside dietary measures to lower elevated levels of total cholesterol, LDL cholesterol, apolipoprotein B (Apo-B), and triglycerides in cases where diet and non-drug interventions are insufficient. Its uses include:
- Lowering total and LDL cholesterol in patients with heterozygous or homozygous familial hypercholesterolemia.
- Managing high cholesterol and triglycerides in mixed dyslipidemia (Fredrickson types IIa and IIb).
- Treating elevated triglyceride levels in hypertriglyceridemia (Fredrickson type IV).
- Treating dysbetalipoproteinemia (Fredrickson type III).
- Reducing ischemic heart events in patients with coronary artery disease who have raised LDL cholesterol, whether symptomatic or asymptomatic.
- Lowering cholesterol in patients with hypercholesterolemia related to diabetes or post-renal transplantation.
Take only as prescribed by a registered physician.
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✔️ Side Effects
Generally well-tolerated. Common side effects include:
Gastrointestinal: Constipation, gas, indigestion, abdominal pain
Other: Headache, infection, rash, muscle/joint pain, fatigue, back pain
✔️ Dosage & Administration
- Adults with high cholesterol or mixed lipid disorders: Start at 10 mg daily; may increase to 80 mg daily depending on response and LDL reduction needed.
- Children (10–18 years): Start at 10 mg daily; max 20 mg unless treating familial hypercholesterolemia, in which case max is 80 mg.
Coronary event prevention: Begin at 10 mg/day, adjust based on lipid profile.
Can be taken any time of day, with or without food. Lipid levels should be re-evaluated within 2–4 weeks of dose changes.
Continue cholesterol-lowering diet during treatment.
- Elderly: Slightly higher drug levels; typically more effective at lowering LDL.
- Children: Data limited; use under specialist supervision.
- Renal Impairment: No dose adjustment needed.
- Hemodialysis: Unlikely to clear the drug due to high protein binding.
- Liver Impairment: Significantly higher plasma levels; use with caution.
✔️ Drug Interactions
- Increased risk of muscle toxicity: When used with cyclosporine, fibrates, niacin, erythromycin, or azole antifungals.
- Antacids: Reduce atorvastatin plasma levels by ~35% but don’t affect LDL-C reduction.
- Colestipol: Lowers atorvastatin levels but enhances LDL-lowering effect when combined.
- Digoxin: Levels rise ~20%; monitor.
- Oral contraceptives: Increases hormone levels; consider when choosing a contraceptive.
- Warfarin: No significant impact on clotting time.
✔️ Contraindications
- Allergy to atorvastatin or any excipients.
- Active liver disease or persistent unexplained liver enzyme elevation.
- History of adverse effects from statins.
✔️ Pregnancy & Lactation
- Pregnancy: Not recommended—may harm the fetus. Discontinue if pregnancy is confirmed or planned.
- Lactation: Atorvastatin may pass into breast milk and could harm a nursing infant; avoid use while breastfeeding.
✔️ Precautions
- Liver function: Test before starting and monitor periodically.
- Muscle issues: Stop if signs of myopathy or high CPK levels appear.
Use cautiously in patients with liver disease or high alcohol intake.
✔️ Storage
Store in a cool, dry place below 30°C. Protect from heat and light. Keep out of children's reach.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
