Atova 20mg Tablet

✔️ Uses of Atova 20mg Tablet

• Treats high blood cholesterol levels
• Prevents the risk of heart attack, stroke, angina, or related health problems

✔️ How does Atova 20mg Tablet work?

Atova 20mg Tablet is a lipid-lowering medicine. It effectively reduces the levels of bad cholesterol (LDL) and triglycerides in the body by blocking the action of an enzyme called HMG-CoA reductase that synthesizes cholesterol within the body. It also acts on the liver and improves the body’s ability to remove lipid particles from the blood. As a result, it reduces blood cholesterol levels and prevents its associated risks.

✔️ Side Effects of Atova 20mg Tablet

• Common Cold
• Difficulty in swallowing
• Diarrhea
• Difficulty in falling asleep
• Joint pain
• Muscle pain
• Skin rash and itching
• Difficulty in breathing
• Urinary tract infection
• Anorexia (loss of appetite)
• Weight gain
• Dizziness
• Having nightmares, insomnia
• Tingling sensation
• Decreased sensation of pain or touch
• Changes in the sense of taste
• Loss of memory
• Blurring of vision

✔️ Quick Suggestions:

• Take Atova 20mg Tablet in the exact dose and duration as recommended by your doctor. Do not exceed the prescribed dose.
• Take the medication at a fixed time for optimal results.
• In addition to taking Atova 20mg Tablet, make certain lifestyle changes to support heart health. These include:
• Following a low-fat, low-salt diet.
• Maintaining a healthy weight.
• Engaging in 30 minutes of exercise daily.
• Quitting smoking.
• Limiting alcohol consumption.
• Avoiding meals that are fried, high in fat, or junk food.
• Atova 20mg Tablet is not recommended during pregnancy if you are planning to become pregnant, or if you are breastfeeding. If you become pregnant while taking this medication, stop taking it immediately and consult your doctor.
• Inform your doctor about all other medicines you take and provide your complete medical history.
• Some common side effects of Atova 20mg Tablet may include headache, muscle ache, diarrhea, swelling of the nasal passages, and nausea/vomiting. If these effects bother you or do not go away, inform your doctor.
• Exploring relaxation techniques such as aromatherapy, yoga, meditation, and breathing exercises can help relax your body and mind.
• Include a healthy diet rich in soluble fiber (beans, legumes, whole grains, flax, apples, and citrus fruits) to help lower cholesterol levels.
• Replace most of your saturated fats with unsaturated fats (avocados, olive oil, fatty fish, nuts) to reduce total cholesterol and LDL cholesterol levels.
• Consider adopting a Mediterranean-style diet, which emphasizes olive oil, fruits, vegetables, nuts, whole grains, and fish, while limiting red meat and most dairy.
• Increase your intake of fruits and vegetables as they contain antioxidants that can help lower LDL cholesterol.
• Minimize the consumption of added sugars according to the recommendations of the American Heart Association (ADA).
• Limit sodium intake to no more than 2,300 mg per day as part of a healthy eating pattern, as recommended by the American Heart Association.
• Avoid consuming excessive amounts of grapefruit juice.
• If you miss a dose of Atova 20mg Tablet, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.

✔️ Indication

Atova 20mg Tablet is used to lower the lipid or bad cholesterol in the blood and reduces the risk of heart disease.

✔️ Pharmacology

Atorvastatin is indeed a selective HMG-CoA reductase inhibitor, which means it specifically targets and inhibits the enzyme HMG-CoA reductase. HMG-CoA reductase is a key enzyme involved in the synthesis of cholesterol in the liver. It catalyzes the conversion of HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme A) into mevalonate, which is an important precursor in the synthesis of sterols, including cholesterol. By inhibiting HMG-CoA reductase, Atorvastatin effectively reduces the production of cholesterol in the liver. This inhibition leads to a decrease in intracellular cholesterol levels. In response to the decreased cholesterol levels, the liver increases the expression of LDL receptors on the surface of liver cells. The increased number of LDL receptors enhances the uptake and catabolism (breakdown) of LDL (low-density lipoprotein) cholesterol particles from the bloodstream. LDL cholesterol is often referred to as "bad" cholesterol because elevated levels are associated with an increased risk of cardiovascular diseases. By reducing cholesterol synthesis and increasing LDL receptor activity, Atorvastatin helps lower plasma levels of total cholesterol and LDL cholesterol. This can have a positive impact on reducing the risk of cardiovascular diseases, such as heart attacks and strokes.

✔️ Dosage & Administration of Atova 20mg Tablet

Primary hypercholesterolemia and combined hyperlipidemia:

• Adults: Usually 10 mg per day, which can be increased up to a maximum of 80 mg once a day, if necessary.
• Children (10-18 years of age): Initially 10 mg per day, with the dosage increasing up to a maximum of 20 mg once a day, if necessary.

Familial hypercholesterolemia:

• Adults: Initially 10 mg per day, with the dosage increasing to 40 mg per day every at least 4 weeks. If necessary, the dosage can be further increased up to the maximum of 80 mg once daily. In heterozygous familial hypercholesterolemia, Atorvastatin can be used in combination with anion exchange resin at a dosage of 40 mg once daily.
• Children (10-18 years): Initially 10 mg per day, with the dosage increasing up to the usual maximum every at least 4 weeks if necessary. The usual maximum dosage is 80 mg once a day.

Prevention of cardiovascular events:

• Adults: Initially 10 mg once daily, and the dosage can be adjusted based on the individual's response to the medication.

Take Atova 20mg Tablet as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Atova 20mg Tablet can be taken with or without meals.

Your doctor will decide the correct dose and therapy duration for you depending on your age, body weight, and health condition. Do not stop taking Atova 20mg Tablet without consulting your doctor.

✔️ Interaction

Drug interactions:

• Antibiotics (cephalexin, tetracycline, gentamicin): There may be interactions between Atova 20mg Tablet and certain antibiotics. It's important to consult with a healthcare professional to assess the potential interactions and adjust the dosages if necessary.
• Antifungals (miconazole, fluconazole, ketoconazole): Atova 20mg Tablet may interact with certain antifungal medications. Consult with a healthcare professional to determine the appropriate course of action.
• HIV medicines (abacavir, retrovir, tenofovir): Interactions may occur between Atova 20mg Tablet and certain HIV medications. Healthcare professionals can provide guidance on managing these interactions.
• Hepatitis C medicines (ribavirin, elbasvir): Atova 20mg Tablet may interact with certain hepatitis C medications. It's important to consult with a healthcare professional to determine the appropriate course of action.
• Anti-arthritis pills (cyclosporin): There may be interactions between Atova 20mg Tablet and cyclosporin. Healthcare professionals can advise on managing these interactions.
• Heart rate-controlling pills (amiodarone): Atova 20mg Tablet may interact with amiodarone. Consult with a healthcare professional to assess the potential interactions and adjust dosages if necessary.
• Anti-hypertensive drugs (verapamil, diltiazem): Interactions may occur between Atova 20mg Tablet and certain anti-hypertensive medications. It's important to consult with a healthcare professional to determine the appropriate course of action.

Food-drug interactions:

• Grapefruit: Atova 20mg Tablet may interact with grapefruit, leading to an increased concentration of the medication in the body. It's generally recommended to avoid consuming excessive amounts of grapefruit or grapefruit juice while taking Atova 20mg Tablets.

Drug-disease interactions:

• Serious liver disease (jaundice), kidney disease, lung disease, and muscle weakness (rhabdomyolysis): Patients with these conditions should be closely monitored while taking Atova 20mg Tablet. Healthcare professionals can provide appropriate monitoring and adjust the treatment plan if needed.

✔️ Contraindications

• If you are allergic to Atova 20mg Tablet or any other ingredients of Atova 20mg Tablet .
• If you have or ever had any liver disease.
• If you are being treated with medicines for hepatitis C like glecaprevir, pibrentasvir.
• If you are pregnant or a breastfeeding woman.

✔️ Pregnancy & Lactation

Atorvastatin is contraindicated during pregnancy and lactation. Women of childbearing potential should use adequate contraceptive measures during treatment with atorvastatin. If a woman becomes pregnant while taking atorvastatin, should be discontinued.

✔️ Precautions & Warnings

• Breakdown of skeletal muscle tissue and kidney failure: Atova 20mg Tablet may cause a breakdown of skeletal muscle tissue, which can lead to kidney failure. This risk is higher in the elderly, individuals with kidney disease, and those with poorly controlled hypothyroidism. Close monitoring is important in these cases.
• Not recommended for children under ten years of age: Atova 20mg Tablet should not be prescribed to children younger than ten years of age. The safety and efficacy of the medication in this age group have not been established.
• Allergic reaction: If you have previously experienced an allergic reaction to Atova 20mg Tablet, it's important to consult with a doctor before taking the medication again.
• Liver problems: Individuals with liver problems, such as jaundice or liver cirrhosis, should consult with a doctor before taking Atova 20mg Tablet. Close monitoring may be necessary.
• Kidney problems: If you have kidney problems, it's important to consult with a doctor before starting treatment with Atova 20mg Tablet. Monitoring kidney function may be required.
• Pregnancy and breast-feeding: Atova 20mg Tablet is not recommended for use during pregnancy or while breastfeeding. Consult with a healthcare professional for alternative options if you are pregnant or planning to become pregnant.
• Severe lung disease: If you have severe lung disease, it's important to consult with a doctor before taking Atova 20mg Tablet.
• Previous heart attack or stroke caused by bleeding in the brain: Individuals with a history of a heart attack or stroke caused by bleeding in the brain should consult with a doctor before taking Atova 20mg Tablet.
• Hypothyroidism: If you have hypothyroidism (underactive thyroid), it's important to consult with a doctor before starting treatment with Atova 20mg Tablet.
• Alcohol consumption: If you drink more than two servings of alcohol per day, it's important to consult with a doctor before takingAtova 20mg Tablet.
• Muscle disorder (fibromyalgia) and damaged muscle tissue (rhabdomyolysis): Individuals with muscle disorders or damaged muscle tissue should consult with a doctor before taking Atova 20mg Tablet.

✔️ Storage Conditions

Store in a dry place away from light and heat. Keep out of reach of children.