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Rapasin 8mg Capsule 1 Strip
Rapasin 8, an alpha-adrenergic antagonist, is employed in the management of benign prostatic hyperplasia. It aids in alleviating symptoms such as difficulty urinating. However, it doesn't reduce the prostate's size.
- Highly effective for BPH treatment.
- Offers high uroselectivity for alpha-1 adrenergic receptors.
- Serves as an alternative for patients unresponsive to Tamsulosin.
- Does not cause orthostatic hypotension.
- Convenient once-daily dosing.
- Always take a registered physician’s advice.
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✅ Description:
Rapasin is prescribed for the treatment of signs and symptoms of benign prostatic hyperplasia (BPH). It is not intended for the management of hypertension.
Silodosin, the active ingredient in Rapasin, is a selective antagonist of post-synaptic alpha-1 adrenoreceptors found in the prostate, bladder base, bladder neck, prostatic capsule, and prostatic urethra. By blocking these receptors, Rapasin induces smooth muscle relaxation, leading to improved urine flow and reduced BPH symptoms.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Dosage & Administration of Rapasin 8
- Standard Dose: 8 mg orally once daily with a meal.
- For Moderate Renal Impairment (CrCl 30-50 mL/min): 4 mg once daily with a meal.
- Always take as directed by a registered physician.
✔️ Drug Interactions
- P-glycoprotein inhibitors (e.g., cyclosporine): May increase Rapasin levels in the blood.
- PDE5 inhibitors combined with Rapasin may cause symptomatic hypotension.
✔️ Overdose Management
- High doses (up to 48 mg/day) can cause postural hypotension.
- Treatment:
- Lie patient in a supine position to restore blood pressure.
- Administer IV fluids if necessary.
- Vasopressors may be used in severe cases.
- Monitor renal function.
- Dialysis is unlikely to help due to high protein binding (97%).
✔️ Elderly Patients
- Clinical trials show no significant difference in effectiveness or safety between older and younger patients.
- Orthostatic hypotension risk:
- 2.3% in patients under 65 years (vs. 1.2% for placebo).
- 2.9% in patients 65+ years (vs. 1.9% for placebo).
- 5.0% in patients 75+ years (vs. 0% for placebo)
✔️ Hepatic Impairment
- Severe hepatic impairment (Child-Pugh score >10): Contraindicated.
- Mild to moderate impairment: No dose adjustment required.
✔️ Renal Impairment
- Severe impairment (CrCl <30 mL/min): Contraindicated.
- Moderate impairment (CrCl 30-50 mL/min): Reduce dose to 4 mg daily.
- Mild impairment (CrCl 50-80 mL/min): No dose adjustment needed.
✔️ Contraindications
- Severe renal or hepatic impairment.
- Concurrent use with strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, itraconazole, ritonavir).
- Hypersensitivity to Silodosin.
✔️ Side Effects
- Most common: Retrograde ejaculation, dizziness, diarrhea, orthostatic hypotension, headache, nasal congestion, and nasopharyngitis.
✔️ Pregnancy & Lactation
- Pregnancy Category B.
- Not intended for women.
- Animal studies show no significant teratogenic effects, but Silodosin should not be used during pregnancy or lactation.
✔️ Precautions & Warnings
- Risk of postural hypotension: Patients may experience dizziness upon starting treatment.
- Should not be combined with other alpha-blockers.
- Cataract surgery patients should inform their ophthalmologist due to the risk of Intraoperative Floppy Iris Syndrome (IFIS).
✔️ Storage Conditions
- Store below 30°C in a dry place away from light.
- Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
