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Silodosin is a selective antagonist of post-synaptic alpha-1 adrenoreceptors located in the prostate, bladder base, bladder neck, prostatic capsule, and prostatic urethra. By blocking these receptors, Silodosin causes smooth muscle relaxation, which improves urine flow and reduces BPH symptoms.
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✅ Description:
Siloflo (Silodosin) is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH). It is not indicated for the treatment of hypertension.
- Highly effective for BPH treatment.
- Exhibits the highest uroselectivity to alpha-1 adrenergic receptors.
- Effective for patients not responding to Tamsulosin.
- Does not cause orthostatic hypotension.
- Convenient once-daily dosing.
Use as prescribed by a registered physician.
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✔️ Overdose Effects
- Symptoms: Postural hypotension is the primary adverse event in overdose.
- Management: If hypotension occurs, maintain the patient in a supine position, and administer intravenous fluids if necessary. Vasopressors may be used if required. Dialysis is unlikely to be beneficial since Siloflo is highly protein-bound (97%).
✔️ Dosage & Administration
- Recommended dose: Silodosin 8 mg orally once daily with a meal.
- For patients with moderate renal impairment (CrCl 30-50 mL/min): 4 mg orally once daily with a meal.
Follow the dosage recommendations provided by your healthcare provider. - Pediatric use: Not indicated for pediatric patients.
- Geriatric use: No significant safety or effectiveness differences were found between younger and older patients, though older patients may experience a slightly higher incidence of orthostatic hypotension.
- Renal impairment: Contraindicated in severe renal impairment (CCr <30 mL/min). For moderate impairment (CCr 30-50 mL/min), reduce the dose to 4 mg once daily. No adjustment is needed for mild renal impairment (CCr 50-80 mL/min).
- Hepatic impairment: Contraindicated in severe hepatic impairment (Child-Pugh score >10). No adjustment for mild to moderate hepatic impairment.
✔️ Contraindications
- Severe renal or hepatic impairment.
- Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, itraconazole, ritonavir).
- History of hypersensitivity to Silodosin.
✔️ Common side effects include:
- Retrograde ejaculation
- Dizziness
- Diarrhea
- Orthostatic hypotension
- Headache
- Nasopharyngitis
- Nasal congestion
✔️ Pregnancy & Lactation
- Pregnancy Category B: Silodosin is not indicated for use in women.
- In animal studies, no teratogenic effects were observed. However, since the drug is not intended for use in pregnant women, consult a healthcare provider before use.
✔️ Interaction
- Strong P-glycoprotein inhibitors (e.g., cyclosporine) may increase the plasma concentration of Siloflo.
- Concomitant use of PDE5 inhibitors and alpha-blockers may cause symptomatic hypotension.
✔️ Precautions & Warnings
- Postural hypotension may occur when starting treatment.
- Not for use with other alpha-blockers.
- Intraoperative Floppy Iris Syndrome (IFIS) may occur during cataract surgery, so inform your ophthalmologist if you are taking Siloflo.
✔️ Storage Conditions
- Store below 30°C in a dry place, protected from light.
- Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
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