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Entresto 50mg 14pcs
Entresto tablets are prescribed for the following conditions:
1. Chronic Heart Failure (NYHA Class II-IV)
- Used to reduce the risk of cardiovascular-related death and hospitalization in patients with chronic heart failure.
- Beneficial for individuals with reduced ejection fraction, meaning the heart's ability to pump blood is weakened.
- Typically administered alongside other heart failure medications, replacing an ACE inhibitor (ACEi) or angiotensin receptor blocker (ARB).
2. Pediatric Heart Failure (Ages 1 Year & Older)
- Approved for treating symptomatic heart failure in children with systemic left ventricular systolic dysfunction.
- Dosage varies based on body weight and should be carefully adjusted.
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✅ Description:
✅ Entresto is an advanced heart failure medication that improves survival and reduces hospitalizations.
✅ It works by inhibiting neprilysin and blocking angiotensin II, leading to improved heart function.
✅ Dosage adjustments are required for pediatrics, the elderly, and patients with kidney or liver impairment.
✅ Regular monitoring is essential to prevent low blood pressure, kidney issues, and high potassium levels.
🚨 Do NOT take it with ACE inhibitors, Aliskiren (in diabetics), or if you have a history of angioedema.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Entresto is a combination medication consisting of:
Sacubitril (Neprilysin Inhibitor)
- Inhibits neprilysin (NEP) via LBQ657, the active metabolite.
- Increases levels of natriuretic peptides (which help reduce fluid retention and lower blood pressure).
Valsartan (Angiotensin Receptor Blocker - ARB)
- Blocks angiotensin II type-1 (AT1) receptors, preventing the harmful effects of angiotensin II (a hormone that constricts blood vessels and raises blood pressure).
- Reduces aldosterone secretion, which helps lower fluid retention and improves heart function.
Together, these components enhance cardiovascular and renal function, providing significant benefits in heart failure management.
✔️ Dosage & Administration
1. Adult Dosage (Heart Failure)
- Starting Dose: 49/51 mg taken twice daily.
- Titration: After 2 to 4 weeks, the dose is doubled to a target of 97/103 mg twice daily, if tolerated.
🔹 Lower Starting Dose (24/26 mg Twice Daily) is Recommended for:
- Patients not previously on ACE inhibitors (ACEi) or ARBs.
- Individuals with severe kidney impairment.
- Patients with moderate liver impairment.
2. Pediatric Dosage (Heart Failure in Children Aged 1 Year & Older)
✅ Weight-Based Dosage Adjustments
| Patient Weight | Starting Dose | Second Dose | Final Dose |
|---|---|---|---|
| Less than 40 kg | 1.6 mg/kg | 2.3 mg/kg | 3.1 mg/kg |
| 40 - 50 kg | 24/26 mg | 49/51 mg | 49/51 mg |
| 50 kg & Above | 49/51 mg | 72/78 mg | 97/103 mg |
💡 Pediatric doses should be adjusted every 2 weeks, depending on the patient's response and tolerance.
🔹 Important: Always take under medical supervision and follow prescribed dosage adjustments.
✔️ 🚨 Caution is required when used with the following medications:
1. Renin-Angiotensin-Aldosterone System (RAAS) Inhibitors
- Should NOT be taken with ACE inhibitors or Aliskiren (in diabetic patients).
- Avoid using with other ARBs, as it can lead to excessive blood pressure reduction.
2. Potassium-Sparing Diuretics
- Increases potassium levels, requiring regular monitoring.
3. NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
- May increase the risk of kidney damage, especially in elderly patients or those with kidney disease.
4. Lithium
- Increases lithium toxicity, leading to severe neurological side effects.
✔️ The most common side effects include:
- Angioedema (swelling of face, lips, throat)
- Hypotension (low blood pressure)
- Kidney function impairment
- Hyperkalemia (high potassium levels)
- Cough
- Dizziness
🚨 Seek immediate medical attention if you experience severe swelling (angioedema), difficulty breathing, or fainting.
✔️ ❌ Entresto is NOT suitable for patients with:
- Allergy to Sacubitril, Valsartan, or any ingredient in the formulation.
- History of angioedema due to previous use of ACE inhibitors or ARBs.
- Concomitant use of ACE inhibitors (must wait at least 36 hours before switching).
- Diabetic patients taking Aliskiren (risk of severe complications).
✔️ Overdose Management
Symptoms:
The most common overdose effect is severe low blood pressure (hypotension).
- Treatment:
- Supportive care (IV fluids, lying down with legs elevated).
- Hemodialysis is NOT effective (due to high protein binding of the drug).
✔️ Pregnancy & Lactation
- Not recommended during pregnancy, as it may cause harm to the fetus.
- Breastfeeding mothers should avoid use, as it is unknown whether the drug passes into breast milk.️
✔️ Geriatric Use (65+ Years & 75+ Years)
- No significant differences in drug behavior were observed.
- Close monitoring is advised in elderly patients with kidney or liver conditions.
✔️ Hepatic (Liver) Impairment
- Mild (Child-Pugh A) → No dose adjustment needed.
- Moderate (Child-Pugh B) → Start with 24/26 mg twice daily and increase as tolerated.
- Severe (Child-Pugh C) → Use NOT recommended due to lack of safety data.
✔️ Renal (Kidney) Impairment
- Mild to Moderate (eGFR 30–90 mL/min/1.73m²) → No dose adjustment needed.
- Severe (eGFR <30 mL/min/1.73m²) → Start at 24/26 mg twice daily, increase gradually.
✔️ Precautions & Warnings
- Risk of Angioedema → Do NOT use in patients with a history of severe swelling (angioedema).
- Low Blood Pressure (Hypotension) → Monitor blood pressure regularly to avoid dizziness or fainting.
- Kidney Function Monitoring → Patients with kidney disease require close monitoring.
- Hyperkalemia (High Potassium Levels) → Regular blood tests are needed to prevent complications.
- Do NOT take ACE inhibitors → Wait at least 36 hours after stopping an ACE inhibitor before starting Entresto.
✔️ Storage:
- Keep below 30°C in a dry place.
- Protect from moisture.
- Keep out of reach of children.
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information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
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