Generic Name: Clopidogrel Bisulphate 75mg
Manufacturer: Incepta Pharmaceuticals Limited
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Indications of Lopirel Tablet
Lopirel 75 is a blood thinner or antiplatelet medication that aids in preventing the development of harmful blood clots in your blood vessels. This reduces your risk of having a heart attack or stroke. A lot of people take this medication to protect their hearts. People with a high risk of developing heart disease are given Lopirel 75. This includes those who have peripheral vascular disease (problems with blood circulation brought on by narrowing of blood vessels), have recently experienced a heart attack or stroke, have irregular heartbeats, or have had certain heart procedures like stenting. It is also used in conjunction with other medications to treat certain types of heart-related chest pain and heart attacks (unstable angina)
Pharmacology of Lopirel Tablet
A prodrug used to treat blood clots is clopidogrel. The P2Y12 class of ADP receptors on platelets serves as an irreversible binding site for its active metabolite, which inhibits platelet activation and aggregation. A dose-dependent suppression of platelet aggregation can be observed two hours after a single oral dose. Repeated 75 mg doses on day one reduce ADP-induced platelet aggregation, and between days three and seven, inhibition reaches a stable state.
Aspirin stops the production of thromboxane A2, a powerful inducer of platelet aggregation and vasoconstriction, by permanently inhibiting platelet cyclooxygenase.
Dosage & Administration of Lopirel Tablet
Interactions of Lopirel Tablet
The risk of bleeding is raised by oral anticoagulants, NSAIDs, Metamizole, SSRIs, and CYP2C19 inhibitors, among other medications. It interacts with tonofovir, valproic acid, varicella vaccine, acetazolamide, and nicorandil.
Contraindications
If you have any of the following conditions, you shouldn't take this combination: hypersensitivity to the drug or any of the ingredients in the product. Examples of current pathological bleeding include cerebral hemorrhage and peptic ulcers.
Side Effects of Lopirel Tablet
This combination is generally well tolerated.
Pregnancy & Lactation
In pregnant women, there are no sufficient and well-controlled trials. It should only be taken if absolutely necessary throughout the first and second trimesters of pregnancy. During the third trimester of pregnancy, it is not recommended. Clopidogrel is not known to be excreted in human breast milk, however, it is known to be excreted in human milk. During breastfeeding, this drug should be avoided.
Precautions & Warnings
Storage Conditions
Keep in a cool & dry place (below 30o C), protected from light & moisture. Keep out of the reach of children.
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