✔ 100% Authentic Product
👁️ Currently Viewing 444
Uritone 20mg+50mg Tablet 1 Strip
Frusemide (a loop diuretic) and Spironolactone (a potassium-sparing diuretic) act on different parts of the renal tubules and offer complementary diuretic effects.
Frusemide inhibits the Na⁺/K⁺/2Cl⁻ cotransporter in the loop of Henle, enhancing excretion of sodium, potassium, and chloride, resulting in significant fluid loss.
Spironolactone counters potassium loss by blocking aldosterone at the distal tubule, promoting sodium excretion while conserving potassium.
100% Genuine Products, Guaranteed
Safe & Secure Payments, Always
Fast, Secure & Efficient Delivery
Proper Packaging
Cash on Delivery - All over Bangladesh
Regular Delivery - 8-12 Hours, Dhaka City*- Regular Delivery - 24-48 Hours, All Over Bangladesh*
✅ Description:
This combination is used to manage:
- Essential hypertension
- Chronic congestive heart failure
- Cirrhosis of the liver with ascites
- Edema from fluid retention
- Primary and secondary hyperaldosteronism
- Edema resistant to standard treatment, linked to aldosterone excess
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Adverse Effects
- Common: Headache, drowsiness, nausea, cramps, diarrhea
- Endocrine: Gynaecomastia, menstrual changes, voice deepening, hirsutism, impotence
- Metabolic: Hyperkalemia, hyponatremia, mild acidosis
- Cardiovascular: Risk of arrhythmias from electrolyte imbalance
- Others: Skin rash, mental confusion, dehydration, hypotension, rare vascular complications in the elderly
✔️ Dosage & Administration
Frusemide 20 mg + Spironolactone 50 mg:
1 to 4 tablets daily depending on patient response (Frusemide 20–80 mg, Spironolactone 50–200 mg).
Frusemide 40 mg + Spironolactone 50 mg:
1 to 2 tablets daily for patients needing higher doses (Frusemide 40–80 mg, Spironolactone 50–100 mg).
Not recommended for pediatric use.
Elderly patients may experience slower drug clearance and should be monitored closely.
✔️ Drug Interactions
- Risk of hyperkalemia when combined with ACE inhibitors or potassium supplements.
- Increased digoxin toxicity with spironolactone.
- Hypokalemia risk with corticosteroids.
- Reduced diuretic effect when used with NSAIDs like indomethacin.
- Increased ototoxicity with aminoglycosides.
- Sucralfate may interfere with frusemide’s action
✔️ Contraindications
- Anuria or acute renal failure
- Severely impaired renal function (creatinine clearance <30 mL/min)
- Hyperkalemia
- Addison’s disease
- Known hypersensitivity to spironolactone, frusemide, or sulfonamides
✔️ Pregnancy & Lactation
Pregnancy: Spironolactone may cross the placenta. Furosemide has shown fetal risks in animal studies. Use only if the benefits justify potential fetal risks, and only with adequate contraception in women of childbearing age.
Lactation: Both drugs pass into breast milk. If treatment is necessary, breastfeeding should be stopped.
✔️ Precautions & Warnings
Use with caution in patients prone to electrolyte imbalances, diabetes, hypotension, enlarged prostate, or hypovolemia.
Regular monitoring of electrolytes, renal function, and fluid status is advised.
✔️ Storage Conditions
Store below 30°C in a dry, light-protected place.
Keep out of reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
