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Uritone 20mg+50mg Tablet 1 Strip
Frusemide (a loop diuretic) and Spironolactone (a potassium-sparing diuretic) act on different parts of the renal tubules and offer complementary diuretic effects.
Frusemide inhibits the Na⁺/K⁺/2Cl⁻ cotransporter in the loop of Henle, enhancing excretion of sodium, potassium, and chloride, resulting in significant fluid loss.
Spironolactone counters potassium loss by blocking aldosterone at the distal tubule, promoting sodium excretion while conserving potassium.
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✅ Description:
This combination is used to manage:
- Essential hypertension
- Chronic congestive heart failure
- Cirrhosis of the liver with ascites
- Edema from fluid retention
- Primary and secondary hyperaldosteronism
- Edema resistant to standard treatment, linked to aldosterone excess
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✔️ Adverse Effects
- Common: Headache, drowsiness, nausea, cramps, diarrhea
- Endocrine: Gynaecomastia, menstrual changes, voice deepening, hirsutism, impotence
- Metabolic: Hyperkalemia, hyponatremia, mild acidosis
- Cardiovascular: Risk of arrhythmias from electrolyte imbalance
- Others: Skin rash, mental confusion, dehydration, hypotension, rare vascular complications in the elderly
✔️ Dosage & Administration
Frusemide 20 mg + Spironolactone 50 mg:
1 to 4 tablets daily depending on patient response (Frusemide 20–80 mg, Spironolactone 50–200 mg).
Frusemide 40 mg + Spironolactone 50 mg:
1 to 2 tablets daily for patients needing higher doses (Frusemide 40–80 mg, Spironolactone 50–100 mg).
Not recommended for pediatric use.
Elderly patients may experience slower drug clearance and should be monitored closely.
✔️ Drug Interactions
- Risk of hyperkalemia when combined with ACE inhibitors or potassium supplements.
- Increased digoxin toxicity with spironolactone.
- Hypokalemia risk with corticosteroids.
- Reduced diuretic effect when used with NSAIDs like indomethacin.
- Increased ototoxicity with aminoglycosides.
- Sucralfate may interfere with frusemide’s action
✔️ Contraindications
- Anuria or acute renal failure
- Severely impaired renal function (creatinine clearance <30 mL/min)
- Hyperkalemia
- Addison’s disease
- Known hypersensitivity to spironolactone, frusemide, or sulfonamides
✔️ Pregnancy & Lactation
Pregnancy: Spironolactone may cross the placenta. Furosemide has shown fetal risks in animal studies. Use only if the benefits justify potential fetal risks, and only with adequate contraception in women of childbearing age.
Lactation: Both drugs pass into breast milk. If treatment is necessary, breastfeeding should be stopped.
✔️ Precautions & Warnings
Use with caution in patients prone to electrolyte imbalances, diabetes, hypotension, enlarged prostate, or hypovolemia.
Regular monitoring of electrolytes, renal function, and fluid status is advised.
✔️ Storage Conditions
Store below 30°C in a dry, light-protected place.
Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
