Losectil Oral Powder 20mg Sachet

✔️ Uses of Losectil Oral Powder

• Gastroesophageal Reflux Disease
• Gastric and duodenal ulcers
• Zollinger-Ellison Syndrome
• Erosive Esophagitis

✔️ How Losectil Dry Powder works

Losectil Oral Powder is a proton pump inhibitor (PPI). It works by reducing the amount of acid in the stomach which helps in the relief of acid-related indigestion and heartburn.

✔️ How to use Losectil Oral Powder

• Check the label for instructions and take Losectil Oral Powder  Sachet in the dosages as directed by your doctor
• It should be taken at least 30 minutes before a meal on an empty stomach. 
• Empty the contents of the sachet into a small cup with 2 teaspoons (30 ml) of water. 
• Drink right away after thoroughly stirring.
• Use no other drinks or meals. Your doctor will determine the appropriate dose and duration for you based on your age, weight, and medical status.

✔️ Side effects of Losectil Oral Powder

• Diarrhea
• Flatulence
• Headache
• Nausea
• Sore throat
• Loss of appetite
• Constipation
• Diarrhoea
• Difficulty in Breathing
• Dizziness
• Muscle pain
• Drowsiness
• Chest pain
• Stomach pain
• Vomiting

✔️ Quick Suggestions:

• Losectil Oral Powder is a well-tolerated medication that gives long-term relief.
• Avoid eating late at night or right before going to bed.
  Inform your doctor if you have watery diarrhea, a fever, or persistent stomach pain.
• Inform your doctor if you do not feel better after 14 days since you may be suffering from another condition that needs care.
• Long-term usage of Losectil Dry Powder Sachet can result in weak bones and a lack of minerals like magnesium. Take calcium and magnesium supplements or calcium and magnesium supplements as directed by your doctor.
• Do not discontinue medication without first consulting your doctor.
• If you experience reduced urine, edema (swelling caused by fluid retention), lower back discomfort, nausea, exhaustion, and a rash or fever, contact your doctor straight once. These symptoms might indicate renal disease.

✔️ Indication

Losectil 20mg Oral Powder is useful for treating erosive esophagitis (food pipe inflammation), resolving symptoms of gastroesophageal reflux disease (heartburn), Zollinger-Ellison syndrome, as well as stomach ulcers. Losectil 20mg Oral Powder acts by inhibiting the proton pump gate irreversibly. (which secretes stomach acid). It can be recommended to people of all ages, including the elderly, pregnant women, and anyone with kidney or liver disorders. These groups usually do not require any dose adjustments. It should not be administered to children under the age of one year because no clinical trials have been conducted.

✔️ Pharmacology

Omeprazole, a benzimidazole replacement, inhibits stomach acid output. It inhibits stomach acid production by inhibiting the hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system in the gastric parietal cell. The antisecretory effect occurs within one hour of oral administration, peaks within two hours, and secretion suppression lasts up to 72 hours. When the medicine is withdrawn, secretory activity gradually restarts, generally within 3 to 5 days.

✔️ Dosage & Administration of

Adult:

• Benign Gastric and Duodenal Ulcer: 20 mg once daily for 4 weeks in duodenal ulceration, 8 weeks in gastric ulceration; dose to be raised to 40 mg daily in severe or recurring cases; maintenance dose for recurrent duodenal ulcer, 20 mg once daily; 10-20 mg daily in the prevention of recurrence in duodenal ulcer.
• NSAID-associated Duodenal or Gastric Ulcer: 20 mg once daily for four weeks, followed by another four weeks if not entirely recovered. In individuals with a history of NSAID-related duodenal or gastric ulcers, 20 mg once daily is recommended as prophylactic.
• Gastro-Esophageal Reflux Disease: 20 mg once daily for four weeks, followed by another four to eight weeks if not entirely healed; 40 mg once daily for eight weeks in gastroesophageal reflux disease resistant to previous treatments; maintenance dosage is 20 mg once daily.
• Long-Term Management of Acid Reflux Disease: 10-20 mg daily.
• Acid-Related Dyspepsia: 10-20 mg once daily for 2-4 weeks.
• Prophylaxis of Acid Aspiration: 40 mg on the preceding evening, then 40 mg 2-6 hours before surgery.
• Zollinger-Ellison Syndrome: Initially 60 mg once daily; usual range 20-120 mg daily (If the daily dose is more than 80 mg, 2 divided doses should be used).
• Helicobacter Pylori Eradication Regimen in Peptic Ulcer Disease: Omeprazole 20 mg twice daily is recommended in conjunction with the following antimicrobial agents: Amoxicillin 500 mg and Metronidazole 400 mg both three times a day for one week, Clarithromycin 250 mg and Metronidazole 400 mg both twice a day for one week, or Amoxicillin 1 g and Clarithromycin 500 mg both twice a day for one week.

Pediatric Use

In Severe Ulcerating Reflux Esophagitis (Child>1 year): 

• If body-weight 10-20 kg, 10-20 -mg once daily for 4-12 weeks; if body weight over 20 kg, 20-40 mg once daily for 4-12 weeks

Renal Dose

Renal impairment: No dosage adjustment is needed.

✔️ Interaction

Losectil Oral Powder should not be administered to a patient who has Clostridium difficile-related diarrhea. Losectil 20mg Oral Powder is suitable for pregnant and nursing women, but should only be used after contacting a doctor. If you have stomach or intestinal cancer, a liver condition, are allergic to Losectil 20mg Oral Powder or are scheduled for an endoscopy in the near future, notify your doctor. 

Ask your doctor if you should stop using Losectil 20mg Oral Powder a few weeks before your endoscopy because it may conceal some of the issues that an endoscopy would reveal. Prolonged usage of Losectil 20mg Oral Powder may increase the risk of osteoporosis-related fractures of the hip, wrist, or spine owing to magnesium depletion. Due to a significant medication interaction, avoid using Losectil 20mg Oral Powder with St John's Wort (plant-based antidepressant), rifampin (antibiotic), and methotrexate (anti-cancer and anti-arthritis therapy).

Losectil 20mg Oral Powder should be not given in patients with C. difficile-induced colitis, liver disease, bone fractures, low Vitamin B12 (anemia), and low magnesium (hypomagnesemia).

Losectil 20mg Oral Powder may interact with a blood thinner (clopidogrel, warfarin), antifungal (ketoconazole, voriconazole, itraconazole, posaconazole), anti-HIV medication (atazanavir, nelfinavir), iron supplements, antibiotic (ampicillin, rifampicin), heart medication (digoxin), and anti-cancer medication. (methotrexate). Inform your doctor if you are using any of these medications.

✔️ Contraindications

Omeprazole is not recommended for patients who have a known hypersensitivity to any of the formulation's ingredients.

✔️ Pregnancy & Lactation

Pregnant women should avoid using Losectil 20mg Oral Powder. It has not been linked to any birth abnormalities. However, it should only be used with your doctor's approval.

Losectil 20mg Oral Powder may enter into breast milk and induce adverse reactions in breastfed infants. A different medication may be chosen, especially if you are breastfeeding a newborn or premature infant. If necessary, it should only be used with your doctor's approval.

✔️ Precautions & Warnings

• You should not use it if you are on a nelfinavir-containing medication. (used for HIV infection). 
• Inform your doctor if you are experiencing any of the following symptoms: liver issues, chronic diarrhea or vomiting, black stools (blood-stained stools), unexpected weight loss, difficulty swallowing, stomach pain, or indigestion. 
• Inform your doctor about all other medications you are taking, since they may impact or be affected by this medication.
• Inform your doctor if you have had an adverse skin reaction to this medication in the past. 
• It should not be administered to children under the age of one year or who weigh less than ten kilograms.
• Pregnant and lactating women should see their doctor before using this medication to avoid adverse effects on the unborn child.
• When a gastric ulcer is suspected, the possibility of gastric cancer should be ruled out first, as treatment with Omeprazole may mask the symptoms and delay diagnosis.
• Losectil 20mg Oral Powder is not suggested for use in infants under the age of one month, or in children with chronic illnesses that require long-term therapy, unless otherwise directed by a doctor. It should be used with caution in children above the age of one month. The dose may be adjusted by your child's doctor based on his or her age and weight. Seek guidance from your child's pediatrician.
• Because of the increased risk of fractures, Losectil 20mg Oral Powder should be taken with caution in senior patients (over the age of 65), especially at larger dosages and for lengthy periods of time (>1 year). Before using Losectil 20mg Oral Powder, consult your doctor.

✔️ Storage Conditions

Protect from light and moisture by storing below 30°C. Keep the medicine out of children's reach.