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Limpa 5/25mg Tablet
Linagliptin functions as a DPP-4 inhibitor, preventing the breakdown of incretin hormones, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). These hormones regulate glucose homeostasis by increasing insulin secretion and reducing glucagon levels in a glucose-dependent manner. GLP-1 also decreases hepatic glucose production.
Empagliflozin, an SGLT2 inhibitor, blocks glucose reabsorption in the kidneys, thereby lowering the renal glucose threshold and promoting glucose excretion through urine. This mechanism helps reduce blood sugar levels.
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Price: ৳ 470
MRP:
৳
500
6%
Off
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✅ Description:
Limpa is prescribed as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
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✔️ Key adverse reactions include:
Serious Conditions:
- Pancreatitis.
- Diabetic ketoacidosis.
- Necrotizing fasciitis of the perineum (Fournier’s gangrene).
- Heart failure.
Infections:
- Urosepsis and pyelonephritis.
- Genital fungal infections.
Other Reactions:
- Hypoglycemia (with insulin or secretagogues).
- Volume depletion (symptomatic hypotension, transient increases in creatinine).
- Hypersensitivity reactions (e.g., rash, itching, urticaria).
- Severe joint pain.
- Bullous pemphigoid.
✔️ Dosage and Administration of Limpa 5/25mg Tablet
Standard Dose:
- 10 mg of Empagliflozin and 5 mg of Linagliptin once daily, taken in the morning, with or without food.
Increased Dose:
- May be increased to 25 mg of Empagliflozin and 5 mg of Linagliptin once daily.
Renal Impairment:
- Assess kidney function before initiation. Do not start therapy if the estimated glomerular filtration rate (eGFR) is below 45 mL/min/1.73 m². Discontinue use if eGFR drops below this threshold.
✔️ In case of overdose: Limpa 5/25mg Tablet
- Immediate Action: Contact a poison control center and provide supportive care.
- Removal of Drug: Gastrointestinal decontamination may be considered.
- Dialysis: Empagliflozin removal via hemodialysis is unstudied, while Linagliptin is unlikely to be removed significantly by hemodialysis or peritoneal dialysis.
✔️ Interactions
- Diuretics: Co-administration may increase urine output and the risk of volume depletion.
- Insulin or Insulin Secretagogues: Combining with these medications may elevate the risk of hypoglycemia.
- P-glycoprotein (P-gp) or CYP3A4 Inducers: Strong inducers, such as Rifampin, can decrease Linagliptin levels, potentially reducing its effectiveness.
- Urine Glucose Test: SGLT2 inhibitors cause increased urinary glucose excretion, potentially resulting in positive glucose test results.
- 1,5-anhydroglucitol (1,5-AG) Assay: Measurements for glycemic control may be unreliable in patients using SGLT2 inhibitors.
✔️ Contraindications
- Severe renal impairment, end-stage kidney disease, or dialysis.
- History of hypersensitivity to Linagliptin or Empagliflozin (e.g., anaphylaxis, angioedema, severe skin reactions, or bronchial hyperreactivity).
✔️ Pregnancy and Lactation
- Pregnancy: Use during the second and third trimesters is not recommended due to insufficient data. Poorly controlled diabetes during pregnancy poses risks to both mother and fetus.
- Lactation: Insufficient information is available, so caution is advised.
✔️ Precautions and Warnings
- Pancreatitis: Acute and sometimes fatal cases have been reported.
- Ketoacidosis: Serious and life-threatening cases requiring hospitalization have occurred, especially in patients with type 1 or type 2 diabetes.
- Volume Depletion: Can cause hypotension or transient changes in renal function.
- Urinary Tract Infections: Increased risk of severe infections, including urosepsis and pyelonephritis.
- Hypoglycemia: Especially when used with insulin or insulin secretagogues.
- Fournier’s Gangrene: Rare but serious necrotizing infection requiring urgent surgical intervention.
- Mycotic Infections: Increased risk of genital fungal infections.
✔️ Storage Conditions
- Store below 30°C, away from light and moisture.
- Keep out of the reach of children.
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