Glyxam 5/10mg Tablet

✔️ Uses of Glyxam 5/10mg Tablet

• Type 2 diabetes mellitus

✔️ How does Glyxam 5/10mg Tablet work?

Glyxam 5/10mg Tablet contains Empagliflozin and Linagliptin. Empagliflozin works by removing excess sugar from the blood through the urine. Linagliptin works by increasing the release of insulin (a chemical substance that helps regulate blood sugar levels) from the pancreas (an organ located in the abdomen). It also increases the activity of certain hormones which helps control blood sugar levels. 

✔️ Side Effects of Glyxam 5/10mg Tablet

• Bladder pain
• Bloody or cloudy urine
• Difficult or painful urination
• Lower back pain
• Fast heartbeat
• Headache
• Unusual tiredness or weakness
• Nausea and vomiting
• Inflammation of pancreas
• Blurred vision
• Sore throat

✔️ Quick Suggestions:

• Take Glyxam 5/10mg Tablet as prescribed by your doctor. It may be taken with or without food. 
• not break, crush, or chew the tablet. Swallow it as a whole with an adequate amount of water. Do not take in larger or smaller amounts than prescribed. 
• Your doctor may change the dose over time based on therapeutic response and clinical condition. 
• Do not discontinue the medicine without consulting your doctor, even if your sugar level is normal. 
• Regularly monitor your blood sugar levels during treatment with this medicine. 
• Consult your doctor if you experience any undesirable effects that persist or worsen. 
• Always carry a sugar candy with you to counteract the unexpected lowering of blood sugar levels. 

✔️ Indications:

Glyxambi 25 mg/5 mg Tablet is a combination medication containing Empagliflozin and Linagliptin. These components work together to help control high blood sugar in individuals with type 2 diabetes. Proper management of blood sugar levels is crucial in preventing complications such as kidney damage, blindness, nerve problems, loss of limbs, and issues with sexual function. Additionally, controlling diabetes can reduce the risk of heart attacks or strokes.

✔️ Pharmacology

Empagliflozin:

• Empagliflozin is a sodium-glucose co-transporter-2 (SGLT2) inhibitor.
• It works by inhibiting SGLT2 in the kidneys, reducing the reabsorption of glucose.
• This leads to increased excretion of glucose in the urine, lowering blood sugar levels.

Linagliptin:

• Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor.
• It increases the levels of incretins, which are natural substances that regulate blood sugar.
• Incretins stimulate insulin release from the pancreas, particularly after meals.
• They also reduce the amount of sugar produced by the liver.

By combining these two mechanisms of action, Glyxambi helps improve glycemic control in individuals with type 2 diabetes.

✔️ Dosage & Administration of Glyxam 5/10mg Tablet

• Initiate with Empagliflozin 10 mg-Linagliptin 5 mg once daily in the morning.
• Adjust based on tolerance.
• Maximum dose: Empagliflozin 25 mg-Linagliptin 5 mg per day.
  • Take Glyxam 5/10mg Tablet as advised by your physician.
  • Swallow the medicine with a glass of water.
  • Do not crush or chew the medicine.
  • Glyxam 5/10mg Tablet can be taken with or without meals.
• Your doctor will decide the correct dose and duration of therapy for you.
• The dosage may be based on factors such as your age, body weight, and the specific condition being treated.
• Do not stop taking Glyxam 5/10mg Tablet unless your doctor advises you to stop.

✔️ Interaction

Before taking Glyxam 5/10mg Tablet, it's important to inform your doctor about any other medications you may be taking, as certain drug interactions can occur. Mention the use of the following medicines to your doctor:

Other medicines used to treat diabetes (e.g., glimepiride, glyburide, gliclazide, rosiglitazone, pioglitazone, insulin) Medicines used to treat epilepsy (e.g., carbamazepine, phenytoin) Diuretics (used to reduce edema and treat hypertension) (e.g., furosemide, hydrochlorothiazide) Lithium (a medicine used to treat mental illness) Rifampicin (a medicine used to treat tuberculosis)

✔️ Contraindications

Hypersensitivity

✔️ Pregnancy & Lactation

Glyxam 5/10mg Tablets are not recommended for use during pregnancy as they may cause harm to the developing fetus. Hence consult your doctor if you are pregnant.

There is no sufficient information available to know whether Glyxam 5/10mg Tablet passes into breast milk. Hence consult your doctor if you are breastfeeding.

✔️ Precaution & Warnings:

Allergies:

• Inform your doctor or pharmacist about any allergies to empagliflozin or linagliptin.
• Check for inactive ingredients that may cause allergic reactions.

Continuous Medication:

• Do not stop Glyxambi abruptly, even if you feel better, without consulting your doctor.
• Abrupt discontinuation may increase sugar levels, raising the risk of complications like retinopathy, nephropathy, and neuropathy.

Conditions for Avoiding Glyxambi:

• Do not take it if you have type 1 diabetes mellitus.
• Avoid in cases of severe kidney or liver disease.

Medical History:

• Inform your doctor if you have heart disease.
• Notify if you are planning to get pregnant or breastfeed.

Control During Stress:

• Blood sugar control may be challenging during stress (fever, infection, injury, or surgery).
• If you eat less or cannot eat due to illness, it can lead to high ketone levels.
• Consult your doctor for potential changes to your treatment plan and medications.

Before Surgery:

• Inform your doctor or dentist about all products you use, including prescription, non-prescription, and herbal products.

✔️ Storage Conditions

Store in a cool & dry place. Protect from light.