Paloxi - IV 0.075 Injection (1.5ml)

Indications

Paloxi Tablet is an antiemetic medication that is commonly used to treat nausea and vomiting caused by medical conditions such as stomach upset. It is also used to prevent nausea and vomiting from surgery, cancer drug therapy, or radiotherapy. Other side effects associated with cancer treatments will not be alleviated by Paloxi Tablet. It also has little effect on motion sickness-induced vomiting. You should take this medication exactly as prescribed by your doctor.

Pharmacology

Palonosetron is a 5-HT3 antagonist with a high affinity for this receptor but little or no affinity for others. Chemotherapeutic agents are thought to cause nausea and vomiting by causing serotonin to be released from enterochromaffin cells in the small intestine, which then activates 5-HT3 receptors on nerve terminals.

Administration & Dosage

• Typical dosage: Adults should take 0.5 mg of the tablet once daily. Adult IV dosage: A single 0.075 mg IV dose should be given over 10 seconds.
• Nausea and vomiting caused by chemotherapy: Adult tablet dosage: 0.5 mg administered 1 hour before the start of chemotherapy. Adult IV dosing: A single 0.25 mg IV dose should be given over 30 seconds approximately 30 minutes before the start of chemotherapy.
• Radiotherapy-induced nausea and vomiting: Approximately 30 minutes before each week of radiation fraction, a single IV dose of 0.25 mg should be administered over 30 seconds.
• Post-operative nausea and vomiting: A single IV dose of 0.075 mg should be administered over 10 seconds prior to anesthesia induction.
• Dosage for children (1 month to 17 years): A single 20 mcg/kg body weight IV dose. Which has a maximum dose of 1.5 mg.

Interaction

In controlled clinical trials, palonosetron injection was administered safely with corticosteroids, analgesics, antiemetics/antinauseants, antispasmodics, and anticholinergic agents. Palonosetron had no effect on the antitumor activity of cisplatin, cyclophosphamide, cytarabine, doxorubicin, or mitomycin C in murine tumor models.

Contraindications

Palonosetron is not recommended for patients who have a history of hypersensitivity to the drug or any of its ingredients.

Side Effect

Headaches and constipation are the most common side effects.

Pregnancy & Lactation

The most common side effects are headaches and constipation.

Precautions & Warnings

• When hypercalcemia occurs, the drug must be stopped immediately.
• Increased fluid intake should also be recommended for patients who have a history of kidney stone formation.
• It works quickly and begins working within 30 minutes.
• Take another dose if you vomit within one hour of taking one.
• Avoid large meals and instead opt for small nourishing snacks throughout the day.
• Drink water on a regular basis to avoid dehydration.

Storage Conditions

Store at or below 30°C, away from light and moisture. Keep out of reach of children.