Gaviflux Oral Suspension

✔️ Uses of Gaviflux Oral Suspension

• Calcium Metabolism Disorders
• Acid Reflux
• Heartburn
• Acid indigestion
• Constipation

✔️ How does Gaviflux work?

Calcium carbonate is an inorganic basic salt that neutralizes the hydrochloric acid in gastric secretions. It also inhibits pepsin action by increasing pH and adsorption. Increases in bicarbonate ion (HCO3-) and prostaglandins may have cytoprotective effects. The neutralization of hydrochloric acid produces calcium chloride, carbon dioxide, and water. 90% of calcium chloride is converted into insoluble calcium salts (e.g. calcium carbonate and calcium phosphate).

Sodium bicarbonate is a systemic alkalizer that raises blood pH, raises plasma bicarbonate, and buffers excess hydrogen ion concentrations, reversing the clinical manifestations of acidosis.

It is also a urinary alkalizer, increasing the excretion of free bicarbonate ions in the urine and thus raising urinary pH. The actual dissolution of uric acid stones may be accomplished by maintaining alkaline urine. Sodium bicarbonate acts as an antacid, chemically neutralizing or buffering existing amounts of stomach acid but has no direct effect on its output. This action raises the pH of the stomach contents, providing relief from hyperacidity symptoms.

✔️ Pharmacology

The product's mode of action is physical and does not rely on systemic circulation absorption. After consumption, the product swiftly combines with stomach acid to produce a raft of alginic acid gel with a pH that is close to neutral and floats on the stomach contents, successfully preventing gastro-esophageal reflux for up to 4 hours. In extreme circumstances, the raft itself may reflux into the esophagus instead of the contents of the stomach and have a demulcent effect. 

✔️ Side Effects of Gaviflux Oral Suspension

• Diarrhea
• Headache

✔️ Dosage & Administration of Gaviflux Oral Suspension

• For oral consumption of 10-20 ml after meals and at night for adults and kids over 12 years old.
• Elderly: There is no need to alter the dosage for this age group.
• Children aged 6 to 12: 5 to 10 ml after meals and before bed. Not advised for children under 6 years old.

✔️ Interaction

In particular, tetracyclines, digoxin, fluoroquinolone, iron salt, ketoconazole, neuroleptics, thyroid hormones, penicillamine, beta-blockers (atenolol, metoprolol, propranolol), glucocorticoids, chloroquine, and biphosphonates (diphosphonates) and estramustine should be administered two hours apart before taking this medication.

✔️ Contraindications

Patients with known or suspected hypersensitivity to the active ingredients or to any of the excipients should not use this medication.

✔️ Pregnancy & Lactation

Pregnancy

• Clinical studies in more than 500 pregnant women as well as a large amount of data from post-marketing experience indicate no malformities nor feta/neonatal toxicity of the active substances. This drug can be used during pregnancy, if clinically needed.

Breastfeeding: 

• The active substances had no effect on breastfed newborns/infants of treated mothers. This medication is safe to take while breastfeeding.

Fertility: 

• Pre-clinical research has shown that Alginate has no negative effect on parental or offspring fertility or reproduction. Clinical evidence suggests that this medication has no effect on human fertility.

✔️ Precautions & Warnings

• After seven days, if symptoms have not subsided, the clinical situation has to be reassessed.
• Calcium carbonate has been extensively researched in children and infants with chronic renal failure and has been shown to be both safe and effective.
• The salt concentration in each dose of 10 ml is 141 mg (6.2 mmol).
• When a salt-restricted diet is suggested, this should be considered. For instance, in some instances of renal insufficiency and congestive heart failure.
• Calcium carbonate weighs 160 mg (1.6 mmol) per 10 ml dosage. Treatment of patients with hypercalcemia, nephrocalcinosis, and recurring renal calculi containing calcium requires caution.
• When calcium carbonate is administered to elderly patients with renal failure, constipation may be a problem. As a result, elderly patients should have their serum calcium and phosphate levels checked.

✔️ Storage Conditions

Keep it cool (below 30°C) and dry, away from light. Keep out of children's reach. Do not store in the refrigerator or freezer.