Tablet Manufacturer/Distributor: Opsonin Pharma Limited Generic Name: Rosuvastatin 10 mg Tablet
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Rosuvastatin is indicated in-
HMG-CoA reductase is the rate-limiting enzyme that transforms 3-hydroxy-3-methyl glutaryl coenzyme A to mevalonate, a precursor of cholesterol. Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase. Rosuvastatin has two mechanisms for altering lipid levels. To begin, it boosts the amount of hepatic LDL receptors on the cell surface, which improves LDL absorption and degradation. Second, Rosuvastatin decreases the total quantity of VLDL and LDL particles by inhibiting VLDL formation in the liver.
The majority of people tolerate rosuvastatin effectively. The most prevalent adverse effects associated with Rosuvastatin were headache, myalgia, constipation, asthenia, stomach pain, and nausea.
The safety in pregnant women has not been established. It is not known whether Rosuvastatin is excreted in human milk or not.
Effects on skeletal muscle (e.g., myopathy and rhabdomyolysis): Usage of the 40 mg dose, advanced age (>65 years), hypothyroidism, renal impairment, and use of cyclosporine, lopinavir/ritonavir, atazanavir/ritonavir, or certain other lipid-lowering medicines all enhance the risks. Patients should be encouraged to report any unexplained muscle discomfort, soreness, or weakness as soon as possible. If indications or symptoms arise, rosuvastatin can be stopped.
Abnormalities in liver enzymes and monitoring: Hepatic transaminases might be persistently elevated. Before and during treatment, liver enzymes should be checked.
Other Anti-anginal & Anti-ischaemic drugs, Statins
Keep below 30oC temperature, protected from light & moisture. Keep out of the reach of children.
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