Generic Name: Atorvastatin 40mg
Manufacturer/Distributor: Opsonin Pharma Limited,
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Indications of Avas 40
Avas 40 is a member of the statin drug class. It lowers cholesterol and lowers the risk of developing heart disease. A fatty substance called cholesterol causes your blood vessels to narrow as it accumulates, which can result in a heart attack or stroke.
Pharmacology of Avas 40
Anti-HMG-CoA Reductase It is a selective inhibitor, atorvastatin. This enzyme plays a rate-limiting role in the transformation of HMG-CoA into mevalonate, a precursor to sterols including cholesterol. By inhibiting HMG-CoA reductase and cholesterol synthesis in the liver, as well as by increasing the number of hepatic LDL receptors on the cell surface, which leads to improved LDL uptake and catabolism, atorvastatin lowers plasma cholesterol and lipoprotein levels.
Dosage & Administration of Avas 40
Primary hypercholesterolemia and mixed hyperlipidemia are two types of hyperlipidemia:
Family history of high cholesterol
Prevention of cardiovascular events-
Interactions
The risk of myopathy while taking Avas 40 is increased by concurrent use of cyclosporin, fibric acid derivatives, erythromycin, azole antifungals, and niacin. No clinically significant interactions between atorvastatin and antihypertensives or hypoglycemic drugs were observed. Patients should be closely monitored if taking atorvastatin along with digoxin, erythromycin, oral contraceptives, colestipol, antacids, or warfarin.
Contraindications of Avas 40
Patients who are hypersensitive to any component of Avas 40 should avoid taking it. Active liver disease or unexplained chronic transaminase increases are contraindicated with atorvastatin. It's also not recommended for patients who have had a significant reaction to HMG-CoA reductase inhibitors in the past.
Side Effects of Avas 40
Avas 40 is well tolerated by most people. Constipation, flatulence, dyspepsia, and abdominal pain are the most common Atorvastatin side effects. Infection, headache, back pain, rash, asthenia, arthralgia, and myalgia are some of the other side effects.
Pregnancy & Lactation
During pregnancy, Avas 40 is not recommended. There is no evidence of safety in pregnant women. There have been no controlled clinical trials with atorvastatin in pregnant women. There have been a few cases of congenital abnormalities following intrauterine exposure to HMG-CoA reductase inhibitors. Reproduction toxicity has been demonstrated in animal studies. The use of atorvastatin by the mother may lower the amount of mevalonate in the fetus, which is a precursor to cholesterol manufacturing. Women who are pregnant, trying to become pregnant, or fear they are pregnant should avoid taking atorvastatin. Treatment with atorvastatin should be stopped for the duration of the pregnancy or until the lady is no longer pregnant.
Precautions & Warnings
Storage Conditions
Keep away from light and heat in a dry location. Keep out of children's reach.
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