Xelopes 40mg Injection | Omeprazole Injection | Price | ePharma
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Xelopes 40mg Injection

Generic: Omeprazole

Type: Injection

Pack Size: 1 Pc

Omeprazole Injection is used to treat Peptic ulcer, H. pylori infection, Gastro-oesophageal reflux disease, Zollinger-Ellison syndrome, Oesophagitis, Acid-related dyspepsia, NSAID-associated ulceration

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Discount Price: ৳ 86
MRP: ৳ 91 5% Off

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✅ Description:

  • Xelopes 40mg Injection, containing Omeprazole, is used to manage conditions such as Zollinger-Ellison syndrome, reflux esophagitis, and ulcers in the stomach and duodenum.
  • Patients should inform their doctor about severe liver problems, unexplained weight loss, stomach pain or indigestion, severe or persistent diarrhea, osteoporosis, or if they need a specific blood test (chromogranin A).
  • Xelopes 40mg Injection can be used in pregnant or breastfeeding women only if advised by a doctor.
  • It is generally not recommended for use in children and adolescents under 18 years of age.
  • Xelopes 40mg Injection should be used with caution in elderly patients (above 65 years) due to an increased risk of fractures, especially with higher doses and prolonged use (over 1 year).

Safety Advices


Alcohol
UNSAFE

It's advised to be cautious when consuming alcohol with Xelopes. Consult your doctor.


Pregnancy
CONSULT YOUR DOCTOR

Xelopes 40mg Injection may be unsafe during pregnancy. Your doctor will assess the benefits and risks before prescribing it.


Breastfeeding
CONSULT YOUR DOCTOR

Xelopes 40mg Injection is likely unsafe during breastfeeding. Consult your doctor for advice.


Driving
CAUTION

It's unknown if Xelopes 40mg Injection affects driving ability. Avoid driving if you experience concentration or reaction issues. 


Kidney
SAFE IF PRESCRIBED

Xelopes 40mg Injection is safe for patients with kidney disease without dose adjustment.


Liver
SAFE IF PRESCRIBED

Use Xelopes 40mg Injection with caution in severe liver disease. Dose adjustment may be necessary. Consult your doctor, especially for long-term use.

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✔️ Uses of Xelopes 40mg Injection
  • Gastroesophageal reflux disease (Acid reflux)
  • Peptic ulcer disease
✔️ How does Xelopes 40mg Injection work?

It works by reducing the amount of acid in the stomach which helps in the relief of acid-related indigestion and heartburn.

✔️ Side Effect of Xelopes 40mg Injection

While generally well-tolerated, Xelopes may cause mild and reversible side effects like skin rash, diarrhea, headache, and gastrointestinal reactions. Rare but serious adverse effects include liver enzyme increases, hepatitis, and anaphylactic shock.

✔️ Quick Suggestions:
  • Avoid eating late at night or before bedtime.
  • Inform your doctor if you get watery diarrhea, fever, or stomach pain that does not go away.
  • Inform your doctor if you do not feel better after taking it for 14 days as you may be suffering from some other problem that needs attention.
  • Long-term use of Xelopes can cause weak bones and a deficiency of minerals such as magnesium. Take adequate dietary intake of calcium and magnesium or their supplements as prescribed by your doctor.
  • Do not stop taking medication without talking to your doctor.
✔️ Indication of Xelopes 40mg Injection

Xelopes is prescribed for various conditions, including gastric and duodenal ulcers, NSAID-associated ulcers, gastroesophageal reflux disease, acid-related dyspepsia, severe ulcerating reflux esophagitis, prophylaxis of acid aspiration during anesthesia, Zollinger-Ellison syndrome, and Helicobacter pylori-induced peptic ulcers.

✔️ Pharmacology

Its active ingredient, omeprazole, inhibits gastric acid secretion by blocking the H+/K+ ATPase enzyme system in gastric parietal cells. This effect begins within an hour of oral administration, peaks within two hours, and lasts up to 72 hours. When discontinued, gastric acid secretion gradually returns over 3 to 5 days.

✔️ Dosage & Administration of Xelopes 40mg Injection

Adult Dose:

  • Peptic ulcer: 20 or 40 mg/day for 4 weeks (duodenal ulcer) or 8 weeks (gastric ulcer). Maintenance dose: 10-20 mg/day.
  • NSAID-associated ulceration: 20 mg once daily.
  • Gastro-oesophageal reflux disease (GERD): 20 mg/day for 4-8 weeks, with a maintenance dose of 20 mg/day after healing.
  • Zollinger-Ellison syndrome: Initially 60 mg once daily, adjusted as required. Dose range: 20-120 mg/day.
  • Prophylaxis of acid aspiration during general anesthesia: 40 mg in the evening and another 40 mg 2-6 hours pre-op.
  • Acid-related dyspepsia: 10 or 20 mg once daily for 2-4 weeks.
  • H. pylori infection: Various regimens involving 20 mg twice daily or 40 mg once daily, combined with antimicrobial agents, for 7-10 days.

Intravenous Dose:

  • For GERD, peptic ulcers, and NSAID-associated ulceration: 40 mg once daily infused over 20-30 minutes or administered slowly over 5 minutes until oral administration is possible.
  • For Zollinger-Ellison syndrome: Initially, 60 mg/day, adjusted according to the response. Daily doses >60 mg/day should be given in 2 divided doses.

Child Dose:

  • GERD: Varies by weight, from 5 mg once daily for children weighing 5-10 kg to 20 mg once daily for children over 20 kg.
  • Erosive esophagitis: Varies by age and weight, from 2.5 mg once daily for infants aged 1 month to 20 mg once daily for children over 20 kg.

Renal Dose: No dosage adjustment is needed for renal impairment.

Xelopes can be administered orally or via intravenous injection or infusion, depending on the patient's needs and circumstances.

✔️ Interaction

It's important to consider potential interactions with other medications, such as ketoconazole, diazepam, phenytoin, warfarin, and clarithromycin, among others. For instance, co-administration with clopidogrel should be avoided due to reduced pharmacological activity.

✔️ Contraindications

Omeprazole is contraindicated in patients with known hypersensitivity to it. 

✔️ Pregnancy & Lactation

Pregnant and breastfeeding women should consult their healthcare provider before using Xelopes.

✔️ Precautions & Warnings

Before starting treatment with omeprazole, it's crucial to exclude the possibility of gastric malignancy. This medication is not recommended during pregnancy, lactation, or for children under one year old. Monitoring magnesium concentrations is advised before starting treatment and periodically thereafter. While limited data suggest omeprazole may be present in breast milk, there's a lack of clinical data on its effects on breastfed infants or milk production. It's essential to weigh the developmental and health benefits of breastfeeding against the mother's clinical need for therapy and any potential adverse effects on the infant from treatment or the mother's underlying condition.

✔️ Storage Conditions:

It's also important to store Xelopes in a dry place away from light and heat, out of the reach of children.

Frequently Asked Questions (FAQ)

Xelopes 40mg Injection should be used with caution in elderly patients (aged above 65 years) due to an increased risk of fractures, especially with higher doses and prolonged use (over 1 year). Consult your doctor for advice before receiving Xelopes 40mg Injection.

Xelopes 40mg Injection should be used with caution in patients suffering from severe liver problems. Your doctor may monitor your liver function test before and during management with Xelopes 40mg Injectionvice before receiving Xelopes 40mg Injection.

Xelopes 40mg Injection suppresses the amount of acid produced in the stomach by blocking the action of the gastric proton pump present in the cells of the stomach lining. This helps to reduce vomiting and promote the healing of damaged stomach tissue in ulcers.

The most common side effects of Xelopes 40mg Injection are headache, diarrhea, stomach pain, nausea, vomiting, constipation, and flatulence. Inform your doctor if any of these side effects worsen or bother you.

Yes, Xelopes 40mg Injection may cause constipation in some individuals. To manage this effect, include fiber-rich foods in your diet such as fresh fruits, vegetables, whole grain cereals, and drink plenty of fluids. If the symptom persists, inform your doctor.
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⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.

📦Pricing Information, Availability:
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