Mezest 40mg Tablet 10pcs

✔️ Uses of Mezest 40

• Breast cancer
• Endometrial cancer

✔️ How does of Mezest 40 work?

Mezest 40 acts by interfering with the production of hormones that cause cancer's development. It helps to reduce cancer symptoms effectively. It can also be used to treat loss of appetite in patients with HIV/AIDS.

✔️ Side-Effects of Mezest 40

• Common:
  • Weight gain (linked to increased appetite).
• Serious:
  • Thromboembolic events: Thrombophlebitis, pulmonary embolism (may be fatal).
  • Glucocorticoid effects:
    • New-onset diabetes or exacerbation of preexisting diabetes.
    • Adrenal insufficiency (may occur during or after therapy).
  • Other: Nausea, hyperglycemia, alopecia, mood changes, lethargy, rash, and carpal tunnel syndrome.

✔️ Quick Suggestions:

• Treats hormone-dependent cancers in women, such as:
  • Breast cancer.
  • Endometrial cancer.
• Manages appetite loss and weight loss in individuals with advanced cancer or AIDS.
• It may take at least 2 months to notice improvements in appetite or symptoms.
• Regular blood tests may be conducted to check:
  • Hormone levels.
  • Blood sugar levels (due to potential glucocorticoid effects).
• Do not use Mezest 40 if you are pregnant or breastfeeding.
• Seek immediate medical attention if you notice:
  • Unexplained swelling and pain in the limbs.
  • Shortness of breath or chest pain.
  • Severe headache.
  • Vision changes (could indicate a blood clot).
• Do not stop taking Mezest 40 suddenly. Consult your doctor before discontinuing.
• Drink plenty of fluids.
• Eat fiber-rich foods (e.g., whole grains, fruits, vegetables).
• Exercise regularly to maintain a healthy weight, especially if overweight or obese.
• Wear loose, layered clothing, particularly during warm nights, to minimize discomfort.
• Include nutrient-rich foods such as:
  • Leafy vegetables, citrus fruits, berries, apples, and peaches.
  • Fatty fish (rich in omega-3), broccoli, cauliflower, beans, yogurt.
  • Herbs and spices for added benefits.
• Get optimal sleep and adequate rest.
• Avoid smoking and alcohol consumption.

✔️ Mezest 40 & Fertility

Mezest 40 Tablets may not affect fertility but may disrupt the menstrual cycle (periods). Though this medicine affects periods, you should take reliable contraceptive measures while using Mezest 40 to prevent pregnancy as it may cause harmful effects to the unborn baby.

✔️ Pharmacology

• Megestrol Acetate is a synthetic antineoplastic and progestational drug.
• Mechanism of action:
  • Inhibits pituitary gonadotropin production, reducing estrogen secretion.
  • Modifies the action of steroid hormones and exerts a cytotoxic effect on tumor cells.
  • Decreases hormone-dependent breast cancer cells and blocks estrogen's stimulatory effects on these cells.
• Pharmacokinetics:
  • Peak plasma concentration: 2–3 hours after a single oral dose.
  • Half-life: 33–38 hours.
  • Excretion: ~66% in urine, ~20% in feces.

✔️ Dosage & Administration: Mezest 40

• Breast Cancer: 160 mg/day.
• Endometrial Carcinoma: 40–320 mg/day (divided doses).
• Minimum treatment duration: 2 months to assess efficacy.
• Dosages as high as 1600 mg/day are generally well-tolerated, with no unexpected severe side effects.

Take Mezest 40 as advised by your physician. Swallow it with a glass of water, and do not chew or crush it. Your doctor will decide the correct dose and duration of Mezest 40 management for you depending on your age, body weight, and disease condition. Do not stop taking Mezest 40 unless your doctor advises you to stop.

✔️ Interaction

• Interactions not fully studied.
• May cause fluid retention, requiring caution in patients prone to fluid retention issues.

✔️ Contraindications:

• Hypersensitivity to Megestrol Acetate or its components.
• Pregnancy (known or suspected).

✔️ Pregnancy & Lactation

• Pregnancy: Category D. Avoid use in the first four months of pregnancy.
• Lactation: Small amounts are excreted in breast milk, and potential harm to the newborn is unknown. Discontinue nursing during treatment.

✔️ Precautions & Warnings

1. Cancer Treatment:
   • Close monitoring is essential for patients with recurrent or metastatic cancer.
2. Thromboembolic Disease:
   • Use cautiously in patients with a history of thromboembolism.
3. Diabetes:
   • Can worsen preexisting diabetes, increasing insulin requirements.
4. Geriatric Use:
   • Limited data on efficacy and safety in patients aged 65+.

✔️ Storage:

• Store below 30°C in a cool, dry place.
• Protect from light and moisture.
• Keep out of reach of children.