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✅ Description:
Indications
Montelukast sodium is suitable for:
- prevention and chronic treatment of asthma
- acute prevention of exercise-induced bronchoconstriction (EIB)
- relief of allergic rhinitis (RA) symptoms: seasonal and perennial allergic rhinitis
Pharmacology
Montelukast is a selective leukotriene receptor antagonist with an oral activity that inhibits the cysteinyl leukotriene receptor (CysLT1). Cysteinyl leukotrienes (LTC4, LTD4, LTE4) are products of arachidonic acid metabolism and are released from various cells, including mast cells and eosinophils. Cysteinyl leukotriene and leukotriene receptor occupancy are related to the pathophysiology of asthma and allergic rhinitis, including airway edema, smooth muscle contraction, and changes in cell activity related to inflammatory processes, which all contribute to asthma Signs and symptoms.
Dosage & Administration
- For adults and adolescents (15 years of age and older): 10 mg tablet once daily in the evening.
- Children 6-14 years: 5 mg Oroflash tablet once daily in the evening.
Interactions
Montelukast has been administered with other therapies routinely used in the prophylaxis and chronic treatment of asthma. In drug-interaction studies, the recommended clinical dose of montelukast did not have clinically important effects on the pharmacokinetics of the following medical products: theophylline, prednisolone, prednisone, oral contraceptives, terfenadine, digoxin, and warfarin.
Contraindications
Montelukast is contraindicated for patients with hypersensitivity to any component of this product.
Side Effects
Generally, Montelukast is well-tolerated. Side effects include fever, headache, cough, abdominal pain, diarrhea, otitis media, influenza, rhinorrhea, and upper respiratory tract infection.
Pregnancy & Lactation
In Pregnancy: Montelukast is a pregnancy category B drug .There is no adequate and well-controlled studies in pregnant women. Montelukast should be used during pregnancy only if clearly needed.
In Lactation: It is not known if Montelukast is excreted in human milk. Caution should be exercised when Montelukast is given to a nursing mother.
Precautions & Warnings
Montelukast is not indicated for use in the reversal of bronchospasm in acute asthma attacks. Montelukast should not be abruptly substituted for inhaled or oral corticosteroids. Patients with known aspirin sensitivity should continue avoidance of aspirin or non-steroidal anti-inflammatory agents while taking Montelukast. Patients should be alert for neuropsychiatric events. Physicians should be alert to eosinophilia, vasculitic rash, worsening pulmonary symptoms, and cardiac complications presenting in their patients.
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.
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