Pregan ER 165mg Tablet

✔️ Uses of Pregan ER 165

• neuropathic pain
• peripheral neuropathic pain
• fibromyalgia syndrome
• peripheral and central neuropathic pain
• certain forms of epilepsy
• anxiety disorders

✔️ Side Effects of Pregan ER 165

• dizziness, drowsiness, headache
• increased appetite
• elevated mood, confusion, disorientation, irritability
• lack of attention, clumsiness, memory impairment
• tremor, difficulty in speaking
• tingling or numbness, sedation, lethargy
• difficulty in sleeping, tiredness
• visual disturbances
• spinning sensation, problems with balance
• dry mouth, constipation, vomiting, flatulence, diarrhoea, nausea, swelling in the abdomen
• muscle cramps, joint or back pain, pain in limbs
• sore throat

✔️ Dosage of Pregan ER

Neuropathic Pain Associated with Diabetic Peripheral Neuropathy

For adults with creatinine clearance ≥60 mL/min:

• Start Pregan ER at 165 mg once daily.
• Depending on response and tolerability, the dose may be increased to 330 mg once daily within 1 week.
• Maximum recommended dose: 330 mg once daily.

Postherpetic Neuralgia

For adults with creatinine clearance ≥60 mL/min:

• Start with 165 mg once daily.
• The dose may be increased to 330 mg once daily within 1 week, depending on response and tolerability.
• If adequate pain relief is not achieved after 2–4 weeks at 330 mg/day, and the medicine is well tolerated, the dose may be increased to as much as 660 mg once daily.
• Doses above 330 mg/day should generally be reserved for patients with persistent pain who tolerate 330 mg/day because higher doses are associated with more adverse effects.
• Maximum recommended dose: 660 mg once daily.

Fibromyalgia

The usual total daily pregabalin dose is 300–450 mg/day with the immediate-release formulation.

When using the extended-release formulation, the appropriate equivalent dose should be selected by the prescribing physician based on the patient's response and tolerability.

✔️ Dosage | Pregan ER

Neuropathic Pain Associated with Spinal Cord Injury

The usual pregabalin dose range is 150–600 mg/day with the immediate-release formulation.

Treatment is generally started at a lower dose and gradually increased according to effectiveness and tolerability. The extended-release equivalent should be determined by the physician.

Switching from Pregabalin Immediate-Release to Pregan ER

When changing from immediate-release pregabalin to the extended-release formulation:

• Take the usual morning dose of immediate-release pregabalin on the day of switching.
• Start the extended-release tablet after the evening meal.
• The extended-release formulation is then taken once daily according to the prescribed dose.

Immediate-Release to Extended-Release Dose Equivalents

Important Note

Pregabalin is primarily eliminated through the kidneys, so dose adjustment is necessary in patients with renal impairment. The appropriate dose for Pregan ER 165 mg should therefore be determined based on kidney function.

✔️ Drug-Drug interactions:

Before taking Pregan ER, inform your doctor if you are taking any of the following medicines:

• Strong opioids (Ex., oxycodone)
• Benzodiazepines (e.g., lorazepam)
• Oral contraceptives (Ex., ethinyl estradiol)

✔️ Before taking Pregan ER, inform your doctor if you:

• have or had constipation
• have a history of drug abuse

✔️ Stop taking Pregan ER and consult your doctor immediately if you experience any of the following side effects:

• Serious skin reaction involving reddish, non-elevated, target-like, or circular patches on the trunk, often with central blisters, skin peeling, ulcers of the mouth, throat, nose, genitals, and eyes (Stevens-Johnson syndrome, toxic epidermal necrolysis)
• Yellow discoloration of the skin and whites of the eyes
• self-harming thoughts

✔️ Storage:

• Store below 25°C.