N-Bion 100mg+200mg+200mcg Tablet

N-Bion is a combination of vitamins B1, B6, and B12 used when there is a deficiency of these vitamins. It may be prescribed as supportive treatment for various nerve-related conditions, including:

• Polyneuropathy, including diabetic, alcoholic, or toxic neuropathy
• Neuritis and neuralgia
• Cervical syndrome
• Shoulder-arm syndrome
• Lumbago and sciatica
• Myalgia
• Intercostal neuralgia
• Herpes zoster-associated nerve pain
• Trigeminal neuralgia
• Supportive treatment of facial nerve palsy

Composition

Each film-coated tablet contains:

• Vitamin B1 (Thiamine Mononitrate) — 100 mg
• Vitamin B6 (Pyridoxine Hydrochloride) — 200 mg
• Vitamin B12 (Cyanocobalamin) — 200 mcg

Tablet:
The usual dose is 1–3 tablets daily, or as directed by the physician.

Children:
There is insufficient information regarding the safety and appropriate use of this medicine in children.

Drug Interactions

No significant drug interactions have been reported. However, vitamin B6 may interfere with the action of levodopa when levodopa is used without a peripheral dopa-decarboxylase inhibitor.

Contraindications

N-Bion should not be used in patients who:

• Are allergic or hypersensitive to any of its ingredients
• Are receiving levodopa therapy without an appropriate peripheral dopa-decarboxylase inhibitor

Side Effects

N-Bion is generally well tolerated. However, allergic or hypersensitivity reactions may occur in some individuals.

Pregnancy & Lactation

The oral tablet formulation is generally preferred during pregnancy and breastfeeding when supplementation is clinically necessary. The injection formulation may contain benzyl alcohol and should therefore be avoided during pregnancy and lactation unless specifically advised by a physician.

Precautions & Warnings

• Use N-Bion only as directed by a healthcare professional.
• Cyanocobalamin should be used cautiously or avoided in certain neurological conditions such as subacute combined degeneration of the spinal cord, according to the underlying cause.
• Prolonged or excessive intake of vitamin B6 can itself cause nerve-related symptoms; therefore, do not exceed the recommended dose without medical supervision.

Overdose

At recommended doses, significant overdose-related problems are not generally expected. If an excessive amount is taken, treatment should be symptomatic and supportive, with medical assessment when necessary.

Therapeutic Class

Specific combined vitamin preparations

Storage

• Store in a cool, dry place below 25°C.
• Protect from light.
• Keep out of reach and sight of children.
• Do not use after the expiry date.