Mirovan 5mg Tablet 1 Strip

✔️ Pharmacology / How Mirovan Works

Mirogabalin belongs to the gamma-amino acid and related compound class. It selectively binds to the α2δ subunit of voltage-gated calcium channels (VGCCs) in the nervous system.

By reducing calcium entry into nerve cells, mirogabalin decreases the release of certain neurotransmitters from presynaptic nerve endings. This reduces excessive neuronal activity and helps relieve pain associated with nerve damage.

After oral administration, mirogabalin is rapidly absorbed, reaching peak blood concentrations in approximately 0.5–1.5 hours. About 25% is bound to plasma proteins. The medicine is distributed throughout the body and is eliminated predominantly through the kidneys, largely in unchanged form. A smaller proportion undergoes hepatic metabolism. Its reported elimination half-life is approximately 2–4.9 hours.

✔️ Side Effects:

• Sleepiness or drowsiness
• Dizziness
• Peripheral edema
• Weight gain

Other possible reactions include:

• Blurred or double vision
• General weakness or malaise
• Loss of appetite
• Nausea
• Vomiting
• Liver dysfunction or jaundice

✔️ Interaction

• Cimetidine and probenecid: May increase mirogabalin concentrations in the blood.
• Lorazepam: Concomitant use may increase central nervous system depressant effects.
• Mirogabalin is a substrate for transporters including OAT1, OAT3, OCT2, MATE1, MATE2-K, and certain UGT enzymes. Medicines that inhibit these pathways may increase mirogabalin exposure.
• Mirogabalin does not significantly inhibit or induce major CYP enzyme systems.
• Taking mirogabalin with food does not produce a clinically significant change in its overall absorption.
• Alcohol should be avoided, as it may increase sedation, dizziness, and impairment of motor coordination.

✔️ Dose Adjustment in Renal Impairment

Because mirogabalin is primarily eliminated through the kidneys, dose adjustment may be required in patients with reduced renal function.

• Mild renal impairment: Start with 5 mg twice daily and gradually increase by 5 mg at intervals of at least 1 week, up to 10 mg twice daily.
• Moderate renal impairment: Start with 2.5 mg twice daily and gradually increase by 2.5 mg at intervals of at least 1 week, up to 7.5 mg twice daily.
• Severe renal impairment: Start with 2.5 mg once daily and gradually increase by 2.5 mg at intervals of at least 1 week, up to 7.5 mg once daily.

Dose selection should be individualized according to renal function and medical advice.

✔️ Mirovan should not be used in patients with:

• Known hypersensitivity to mirogabalin or any component of the formulation.

Patients with renal or hepatic impairment require appropriate assessment and dose adjustment rather than routine use at standard doses.

✔️ Hepatic Impairment

A single 15 mg dose has not been associated with significant additional adverse reactions in patients with mild to moderate hepatic impairment. There is limited information regarding its use in patients with severe hepatic impairment, so medical supervision is recommended.

✔️ Pregnancy & Lactation

Pregnancy:
Mirovan should be used during pregnancy only when the expected therapeutic benefit is considered to outweigh the potential risk to the fetus. Animal studies have indicated placental transfer.

Breastfeeding:
Animal studies have reported transfer of mirogabalin into milk. A healthcare professional should assess the benefits of treatment against the benefits of breastfeeding before deciding whether to continue or discontinue breastfeeding.

✔️ Safety Information:

• Mirovan may cause dizziness, drowsiness, blurred vision, double vision, or, rarely, loss of consciousness.
• Avoid driving, operating machinery, or performing hazardous activities until you know how the medicine affects you.
• Elderly patients should take particular care because dizziness may increase the risk of falls and fractures.
• Mirogabalin may cause weight gain, particularly during prolonged treatment.
• Patients with renal impairment may require dose adjustment.
• If blurred or double vision develops or persists, consult your doctor.
• Stop the medicine and seek immediate medical attention if signs of a serious allergic reaction occur.
• Inform your doctor about all medicines and supplements you are taking before starting treatment.

✔️ Storage:

• Store below 30°C.
• Keep in a dry place away from direct light and moisture.
• Keep out of reach of children.
• Use the medicine only according to the prescribed dose and duration.