Nintoin 50mg Capsule 10pcs

Uses of Nintoin 50mg Capsule

• Treatment of Bacterial infections of urinary tract

How does Nintoin 50mg Capsule work?

Nintoin 50mg Capsule effectively treats and prevents urinary tract infections by killing bacteria present in the urethra, bladder, and/or kidneys. It mainly acts by disrupting the production of genetic material present in the bacterial cell.

Side Effects of Nintoin 50mg Capsule

• Skin rash
• Fever and chills
• Burning or tingling sensation
• Headache
• Drowsiness
• Diarrhea
• Excessive gas in the stomach

Quick Suggestions:

• Nintoin 50mg Capsule treats and prevents uncomplicated urinary tract infections.
• Finish the prescribed course of medicine, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.
• Take it with food to avoid nausea, which is a common side effect.
• It can turn your urine a dark yellow or brown color. This is normal and nothing to worry about.
• Do not take it for longer or more often than prescribed by your doctor.

Indication of Nintoin 50mg Capsule

Nintoin 50mg Capsule is an antibiotic medicine. It is used for the treatment and prevention of uncomplicated urinary tract infections.

Pharmacology

Nitrofurantoin is an antibacterial agent that works particularly well for infections of the urinary tract. Extremely solvent in urination, nitrofurantoin may give poop a brown hue. Ribosomal proteins and other macromolecules produced by bacteria are inactivated or altered by nitrofurantoin. It has been demonstrated that nitrofurantoin is effective against pursuing microscopic organisms: Grass-Feeding Aerobes Enterococcus faecalis, Staphylococcus aureus, Streptococcus agalactiae, Gather D streptococci, and Viridans gather streptococci are among the staphylococci that are Coagulase-negative and include Staphylococcus epidermidis. Escherichia coli, Citrobacter amalonaticus, Citrobacter diversus, Citrobacter freundii, Klebsiella oxytoca, and Klebsiella ozaena are examples of Gram-negative Aerobes.

Dosage & Administration of Nintoin 50mg Capsule

For adults, the recommended dosage of Nitrofurantoin capsules is as follows:

• Acute Uncomplicated Urinary Tract Infections (UTIs): The typical dosage is 50 mg taken four times daily for a duration of 7 days. This regimen is used to treat acute episodes of UTIs.
• Long-Term Suppression: For long-term suppression of UTIs, the usual dosage is 50-100 mg taken once a day. This regimen is used to prevent recurrent UTIs and may be prescribed for a prolonged period of time as determined by your doctor.
• Prophylaxis: In certain situations, such as before urological procedures, Nitrofurantoin may be used as prophylaxis to prevent UTIs. The recommended dosage is 50 mg taken four times daily. It should be taken starting before the procedure and continued for three days afterward.

Take Nintoin 50mg Capsule as advised by your physician. Swallow Nintoin 50mg Capsule with a glass of water and do not crush or chew it. Nintoin 50mg Capsule should always be taken with food or milk for effective working and to avoid stomach upset. It's important to note that these dosage recommendations are general guidelines and may vary depending on individual factors and the specific instructions provided by your healthcare provider. Always follow your doctor's instructions regarding the dosage and duration of Nitrofurantoin treatment.

Interaction

When Nitrofurantoin is taken together with antacids containing Magnesium Trisilicate, it can interfere with the absorption and effectiveness of certain uricosuric medicines, such as Probenecid and Sulfinpyrazone. Uricosuric medicines are used to treat conditions like gout by increasing the excretion of uric acid from the body.

The presence of Magnesium Trisilicate in antacids can reduce the absorption rate and extent of these uricosuric medicines, making them less effective in lowering uric acid levels. Additionally, Nitrofurantoin can also be affected by the interaction with Magnesium Trisilicate, as it can limit the secretion of Nitrofurantoin in the renal tubules (part of the kidney involved in urine formation and excretion).

To ensure the optimal effectiveness of both Nitrofurantoin and uricosuric medicines, it is advisable to separate their administration. It is recommended to take Nitrofurantoin and uricosuric medicines at different times, with an appropriate time interval between them. This helps to avoid any potential interactions and allows for proper absorption and effectiveness of each medication.

Contraindications

Severe Renal Impairment: If you have severe renal impairment, such as anuria (absence of urine production), oliguria (reduced urine production), significantly elevated serum creatinine levels, or creatinine clearance (CrCl) below 60 ml/min, the use of nitrofurantoin may be contraindicated or require dosage adjustment. Your healthcare provider will determine the appropriate course of action.

Hypersensitivity to Nitrofurans: If you have a known hypersensitivity or allergic reaction to nitrofurans or any components of nitrofurantoin, its use should be avoided. Allergic reactions can range from mild skin rashes to severe systemic reactions, including anaphylaxis.

G6PD Deficiency: Nitrofurantoin use should be avoided in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. G6PD deficiency is an enzyme deficiency that can lead to hemolysis (destruction of red blood cells) when exposed to certain medications, including nitrofurantoin.

Infants Under 3 Months of Age: Nitrofurantoin is not recommended for use in infants younger than 3 months old. Safety and efficacy data in this age group are limited.

Pregnancy at Term, During Labor and Delivery, or Imminent Onset of Labor: Nitrofurantoin should not be used in pregnant women at term (near the end of pregnancy), during labor and delivery, or when the onset of labor is imminent. There is a potential risk to the baby during these stages.

Pregnancy & Lactation

Pregnancy Category B. Limited and inconclusive studies have been conducted on the use of this medication in pregnant women. It should only be used during pregnancy if it is absolutely necessary. Small amounts of nitrofurantoin have been detected in human breast milk. Considering the potential for significant side effects in nursing infants under one month old, a decision should be made regarding whether to discontinue breastfeeding or discontinue the medication, taking into account the importance of the drug to the mother.

Precautions & Warnings

In elderly patients, caution should be exercised when using Nitrofurantoin. It is important to monitor hepatic (related to the liver) and pulmonary (related to the lungs) function during prolonged therapy to ensure the medication is well-tolerated and does not cause any adverse effects.

If a patient has pre-existing pulmonary, hepatic, neurological, or allergic disorders or a predisposition to peripheral neuropathy (damage to the nerves in the extremities), special care should be taken when considering the use of Nitrofurantoin. This includes individuals with conditions such as renal impairment (kidney dysfunction), anemia, diabetes mellitus (high blood sugar), electrolyte imbalance, debility (weakness), and vitamin B deficiency.

If signs of peripheral neuropathy, such as numbness, tingling, or pain in the hands or feet, occur during treatment with Nitrofurantoin, the medication should be discontinued.

Regarding lactation, Nitrofurantoin enters breast milk. Therefore, it is recommended to discontinue the drug or avoid nursing while taking Nitrofurantoin to prevent potentially adverse effects on the breastfed infant.

Storage Conditions

Do not store above 30°C. Keep away from light and out of the reach of children.