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Nitrofur SR is specifically indicated for the treatment and prevention of urinary tract infections (UTIs) caused by susceptible strains of Escherichia coli, Enterococci, Staphylococcus aureus, Staphylococcus saprophyticus, and selected strains of Klebsiella and Enterobacter species.
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✅ Description:
Nitrofurantoin is a urinary tract-specific antibacterial agent. It dissolves readily in urine, sometimes causing a brownish tint. The drug exerts its effect by interfering with bacterial ribosomal proteins and other vital macromolecules, inhibiting bacterial growth.
Active Against:
Gram-Positive Aerobes: Staphylococcus saprophyticus, Coagulase-negative Staphylococci (e.g., S. epidermidis), Enterococcus faecalis, Streptococcus agalactiae, Group D and Viridans group Streptococci.
Gram-Negative Aerobes: Escherichia coli, Citrobacter spp., Klebsiella spp.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Dosage & Administration
Adults (Tablets/Capsules)
Uncomplicated UTIs: 50–100 mg four times daily for 7 days or 3 days after urine becomes sterile.
Long-term suppression: 50–100 mg at bedtime.
Prophylaxis: 50 mg four times daily during the procedure and for 3 days post-procedure.
Nitrofurantoin SR Capsule
Adults & children >12 years: One 100 mg capsule every 12 hours for 7 days.
Surgical prophylaxis: One capsule twice daily on the day of procedure and for the following 3 days.
Children (Oral Suspension)
Dosage: 5–7 mg/kg/day divided into 4 doses.
Not recommended for infants under 1 month.
| Weight (kg) | Dose (4x daily) |
|---|---|
| 7–11 | ½ tsp (2.5 ml) |
| 12–21 | 1 tsp (5 ml) |
| 22–30 | 1½ tsp (7.5 ml) |
| 31–41 | 2 tsp (10 ml) |
Pediatric long-term therapy: As low as 1 mg/kg/day, in one or two divided doses.
✔️ Overdose Management
- Overdose is rare but may cause gastric irritation and vomiting.
- Induce vomiting if necessary and seek medical attention.
✔️ Side Effects
Common: Nausea, headache, flatulence
Less frequent: Diarrhea, indigestion, abdominal discomfort, dizziness, constipation, drowsiness, vomiting
✔️ Drug Interactions
Antacids (especially those with magnesium trisilicate): Can reduce drug absorption.
Probenecid, Sulfinpyrazone: Can decrease renal clearance of Nitrofurantoin.
Other interactions: Use caution with drugs that slow gastric emptying or affect urine pH.
✔️ Contraindications
- Severe renal impairment (anuria, oliguria).
- Late-stage pregnancy (38–42 weeks), during labor and delivery.
- Known allergy to Nitrofurantoin.
✔️ Use in Pregnancy & Breastfeeding
Pregnancy Category B: Should be used only when clearly necessary. Avoid use close to delivery.
Breastfeeding: Excreted in small amounts in breast milk. Avoid in nursing infants under one month due to potential risks.
✔️ Precautions
Discontinue immediately if pulmonary reactions (acute or chronic) occur.
Avoid use with magnesium-containing antacids.
Use with caution in the elderly and in patients with lung, liver, or kidney disorders.
✔️ Storage
- Store below 30°C, protect from light.
- Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
