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NFT 100mg Capsule
NFT is specifically indicated for both the treatment and prevention of urinary tract infections (UTIs) caused by susceptible strains of Escherichia coli, Enterococci, Staphylococcus aureus, Staphylococcus saprophyticus, and selected Klebsiella and Enterobacter species.
Contraindicated in infants under 1 month of age
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✅ Description:
Nitrofurantoin is a bactericidal agent specifically active in the urinary tract. It is rapidly excreted into the urine, where it exerts its antibacterial effects by altering bacterial ribosomal proteins and other macromolecules, disrupting vital bacterial processes. Its spectrum includes gram-positive (e.g., Staphylococcus saprophyticus, Enterococcus faecalis) and gram-negative bacteria (e.g., Escherichia coli, Klebsiella species). The urine may appear brownish due to the drug's presence—this is harmless.
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✔️ Composition
- Capsule 50 mg: Contains Nitrofurantoin (as macrocrystals) USP 50 mg
- Capsule 100 mg: Contains Nitrofurantoin (as macrocrystals) USP 100 mg
- Oral Suspension: Each 5 ml contains Nitrofurantoin Monohydrate USP equivalent to Nitrofurantoin 25 mg
✔️ Dosage & Administration
Adults
Acute uncomplicated UTIs: 50–100 mg four times daily for 7 days or at least 3 days after urine becomes sterile
Long-term prophylaxis: 50–100 mg at bedtime
Surgical prophylaxis: 50 mg four times daily during the procedure and for 3 days after
Sustained Release (SR) 100 mg: One capsule every 12 hours for 7 days
✔️ Side Effects
Common: Nausea, headache, flatulence
Less common: Diarrhea, abdominal pain, dizziness, drowsiness, dyspepsia
Rare but serious: Peripheral neuropathy, hepatotoxicity, pulmonary fibrosis, and hypersensitivity reactions
✔️ Children
Therapeutic dose: 5–7 mg/kg/day in four divided doses
Prophylaxis: 1–2 mg/kg/day in single or divided doses
✔️ Drug Interactions
- Magnesium trisilicate reduces absorption
- Probenecid and sulfinpyrazone reduce renal excretion
- Quinolones may show antagonistic effects
- Urinary alkalinizers or carbonic anhydrase inhibitors can reduce Nitrofurantoin’s efficacy
✔️ Contraindications
- Severe renal impairment (e.g., anuria, oliguria, CrCl <60 mL/min)
- Late pregnancy (38–42 weeks), during labor, or imminent delivery
- Known hypersensitivity to Nitrofurantoin
- Infants less than 1 month of age
✔️ Pregnancy & Lactation
Pregnancy Category B
Use only when clearly necessary, especially in early pregnancy. Avoid during the last trimester.
Small amounts may be present in breast milk—not recommended while breastfeeding infants under 1 month.
✔️ Precautions & Warnings
- Monitor hepatic, pulmonary, and neurological function during prolonged use
- Discontinue immediately if signs of pulmonary reactions or peripheral neuropathy occur
- Use cautiously in the elderly, diabetics, or those with renal impairment, anaemia, or vitamin B deficiency
- Avoid magnesium trisilicate-containing antacids during treatment
✔️ Storage Conditions
Store below 30°C, protect from light, and keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
