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Napexa 375mg+20mg Tablet
Napexa is a combination of two medicines: Naproxen and Esomeprazole, which relieve pain. Naproxen is a non-steroidal anti-inflammatory drug (NSAID) that works by blocking the release of certain chemical messengers that cause fever, pain, and inflammation (redness and swelling). Esomeprazole is a proton-pump inhibitor, which reduces the amount of acid in the stomach and prevents damage to the stomach lining caused by Naproxen.
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Regular Delivery: 24-48 Hours, Dhaka City* Charge Tk.39-59- Regular Delivery: 48-96 Hours, Other Cities* Charge Tk.99-125
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100% Genuine Products, Guaranteed
Safe & Secure Payments, Always
Fast, Secure & Efficient Delivery
Proper Packaging
- Cash on Delivery - All over Bangladesh
- Regular Delivery: 24-48 Hours, Dhaka City* Charge Tk.39-59
- Regular Delivery: 48-96 Hours, Other Cities* Charge Tk.99-125
- ফ্রি ডেলিভারিঃ - ১৯৯৯ টাকা+ অর্ডারে, ঢাকা
শহরে
- ফ্রি ডেলিভারিঃ - ৪৯৯৯ টাকা+ অর্ডারে, ঢাকার
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- Google Play Store থেকে ডাউনলোড
- Apple Store থেকে ডাউনলোড
📲 মোবাইল অ্যাপ অর্ডারে সাশ্রয় বেশী
✅ Description:
Napexa is a combination medication used for the relief of pain and inflammation. It is effective in conditions such as arthritis, muscle pain, back pain, toothache, and ear or throat pain.
It should be taken with food to minimize stomach irritation. The dosage depends on the condition being treated and individual response. Always follow your doctor’s instructions and avoid exceeding the recommended dose or duration.
Common side effects include headache, nausea, vomiting, diarrhea, indigestion, gas, and abdominal discomfort. If these persist or worsen, consult your doctor.
Before starting treatment, inform your physician if you have a history of stomach ulcers, bleeding disorders, high blood pressure, or heart, kidney, or liver disease. Also disclose all other medications you are taking to avoid potential interactions. Pregnant or breastfeeding women should seek medical advice before use. Alcohol consumption should be avoided as it may increase side effects.
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✔️ Uses of naproxen and esomeprazole
The combination of naproxen and esomeprazole is used to manage the signs and symptoms of:
- Osteoarthritis
- Rheumatoid arthritis
- Ankylosing spondylitis
It is also prescribed to reduce the risk of NSAID-induced gastric ulcers in patients who require long-term anti-inflammatory therapy.
✔️ Side Effects:
- Indigestion and gastritis
- Diarrhea
- Gastric ulcer
- Upper abdominal pain
- Nausea
✔️ This formulation consists of a rapid-release layer of esomeprazole magnesium and an enteric-coated core of naproxen.
- Esomeprazole is released first in the stomach, reducing acid secretion by inhibiting the proton pump (H+/K+ ATPase) in gastric parietal cells. This lowers stomach acidity.
- Naproxen, a non-steroidal anti-inflammatory drug (NSAID), is released later in the small intestine and works by inhibiting prostaglandin synthesis, thereby reducing pain, inflammation, and fever.
✔️ Interaction
- NSAIDs may reduce the effectiveness of ACE inhibitors, diuretics, and beta-blockers
- Increased risk of bleeding when used with warfarin
- Esomeprazole may alter the absorption of drugs affected by gastric pH
✔️ Dosage & Administration
Use the lowest effective dose for the shortest duration based on individual treatment goals.
Adults (Rheumatoid arthritis, Osteoarthritis, Ankylosing spondylitis):
- One tablet twice daily of either:
- 375 mg naproxen / 20 mg esomeprazole
- 500 mg naproxen / 20 mg esomeprazole
Adolescents (≥12 years):
- >50 kg: Same as adult dose
- 38–50 kg: One tablet (375 mg/20 mg) twice daily
If a lower dose of esomeprazole (below 40 mg daily) is required, alternative therapy should be considered.
✔️ Pregnancy & Lactation
- Classified as pregnancy category C
- Should be avoided in late pregnancy due to the risk of premature closure of the fetal ductus arteriosus
- Not recommended for use during breastfeeding due to the naproxen component
✔️ Contraindications:
- Patients with hypersensitivity to naproxen, esomeprazole, or other similar drugs
- Individuals with a history of allergic reactions to NSAIDs (e.g., asthma, urticaria)
- Patients undergoing coronary artery bypass graft (CABG) surgery
✔️ Precautions & Warnings
- Use cautiously in patients with cardiovascular disease or risk factors
- Monitor patients with fluid retention or heart failure
- Long-term use should be carefully evaluated due to potential risks
✔️ Storage:
- Store below 30°C
- Protect from light and moisture
- Keep out of reach of children
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
