Naproxen + Esomeprazole is used for Pain Relief.
🛒 How to order this item?
100% Genuine Products, Guaranteed
Safe & Secure Payments, Always
Fast, Secure & Efficient Delivery
Proper Packaging
Show More
Naprosyn Plus 500/20mg Tablet is a combination medication that belongs to the group of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). It contains Naproxen, which is an anti-inflammatory drug, and esomeprazole, an antacid.
Naproxen works by blocking the action of the body's cyclo-oxygenase (COX) enzyme, which reduces the production of certain chemicals called prostaglandins. These prostaglandins are responsible for pain and inflammation. By inhibiting their production, Naproxen helps alleviate mild to moderate pain, reduce swelling, and decrease joint stiffness.
However, Naproxen can cause gastric discomfort, acidity, and an increased risk of stomach ulcers. To mitigate these effects, Naprosyn Plus 500/20mg Tablet combines Naproxen with esomeprazole, which is a proton pump inhibitor. Esomeprazole reduces the amount of acid produced by the stomach, thereby protecting the stomach from damage caused by Naproxen.
It is important to take Naprosyn Plus 500/20mg Tablet as prescribed by your doctor and for the recommended duration. Common side effects may include indigestion, stomach pain, constipation, dizziness, nausea, and diarrhea. Most of these side effects are temporary and do not require medical attention. However, if they persist or worsen, it is advisable to consult your doctor.
Before taking Naprosyn Plus 500/20mg Tablet, inform your doctor about any known allergies to Naproxen, esomeprazole, NSAIDs, or other medications. If you are pregnant, breastfeeding, or have a history of heart rhythm problems or ulcers caused by painkillers, it is important to inform your doctor. Additionally, patients above the age of 65, and those with pre-existing cardiac, gastrointestinal, respiratory, liver, kidney diseases, or bleeding disorders should use Naprosyn Plus 500/20mg Tablet only under medical supervision. It is essential to keep your doctor informed about your health condition and all the medications you are taking to avoid any potential side effects.
You are recommended to avoid alcohol consumption with Naprosyn Plus 500/20mg Tablet as it may increase the risk of stomach bleeding and ulcer.
Pregnant women must consult a doctor before consuming Naprosyn Plus 500/20mg Tablet.
Women who are breastfeeding must consult a doctor before consuming Naprosyn Plus 500/20mg Tablet.
Naprosyn Plus 500/20mg Tablet may cause dizziness, tiredness, drowsiness, or vision problems in some people. Do not drive or operate machinery during the course of medication.
Caution should be used in patients with severe renal impairment.
Naprosyn Plus 500/20mg Tablet is to be used with caution in people having liver diseases. Dose adjustments may be necessary. So, you should use it only with your doctor's prescription.
Naprosyn Plus 500/20mg Tablet is a combination of two medicines: Naproxen is a non-steroidal anti-inflammatory drug (NSAID) that works by blocking the release of certain chemical messengers that cause fever, pain, and inflammation (redness and swelling). Esomeprazole is a proton-pump inhibitor. which reduces the amount of acid in the stomach and prevents damage to the stomach lining caused by Naproxen.
The common side effects of taking Naprosyn Plus 500/20mg Tablet may include:
Uncommon side effects may include:
Rare side effects may include:
If you experience any of the following serious side effects, stop taking Naprosyn Plus 500/20mg Tablet and consult your doctor immediately:
It is important to consult your doctor if you experience any of these side effects or have any concerns while taking Naprosyn Plus 500/20mg Tablet.
In addition to medication, there are lifestyle measures you can take to manage painful conditions:
On the other hand, it is advisable to avoid foods or drinks that can trigger acid reflux or heartburn, such as onions, peppermint, chocolate, caffeinated beverages, citrus fruits or juices, tomatoes, and high-fat and spicy foods. Additionally, it is recommended to avoid smoking and limit alcohol consumption.
Remember to follow your doctor's advice and instructions regarding the use of Naprosyn Plus 500/20mg Tablet and any lifestyle modifications. If you have any concerns or experience adverse effects, consult your doctor for further guidance.
Naprosyn Plus 500/20mg Tablet is indicated for the relief of -
Naprosyn Plus 500/20mg Tablet is a combination medication that consists of an enteric-coated Naproxen core and an instant-release Esomeprazole Magnesium coating. This unique formulation allows for the sequential release of the two active ingredients.
Naproxen is classified as a nonsteroidal anti-inflammatory drug (NSAID) and possesses analgesic (pain-relieving) and antipyretic (fever-reducing) properties. It works by inhibiting the production of prostaglandins, which are substances involved in pain, inflammation, and fever.
Esomeprazole, on the other hand, belongs to a class of medications called proton pump inhibitors (PPIs). It selectively inhibits the H+/K+-ATPase, an enzyme responsible for acid secretion in the gastric parietal cells of the stomach. By specifically targeting the proton pump, Esomeprazole effectively reduces the production of stomach acid, resulting in a decrease in gastric acidity.
The sequential release of Esomeprazole followed by Naproxen allows Esomeprazole to exert its acid-reducing effects in the stomach first, protecting the stomach lining from potential irritation by Naproxen. Naproxen, then released in the small intestine, can exert its anti-inflammatory and pain-relieving effects.
This combination of Naproxen and Esomeprazole provides the dual benefit of relieving pain and inflammation while reducing the risk of stomach irritation and ulcers associated with Naproxen use alone.
Before using Naprosyn-Plus® (containing Naproxen and Esomeprazole), it is important to carefully consider the potential benefits and risks associated with the medication. It is recommended to discuss with your healthcare provider or doctor the available treatment options and determine if Naprosyn-Plus® is the most suitable choice for your individual treatment goals.
When using Naprosyn-Plus®, it is advised to use the lowest effective dose for the shortest duration necessary to achieve the desired therapeutic outcomes. If a lower dose of Esomeprazole (less than a total daily dose of 40 mg) is more appropriate for your condition, alternative treatment options should be considered.
For elderly patients, studies have shown that while the total plasma concentration of naproxen remains unchanged, the unbound plasma fraction of naproxen increases in the elderly population. Caution should be exercised when higher doses are required, and dosage adjustments may be necessary in elderly patients. Similar to other medications used in the elderly, the lowest effective dose should be used.
Patients with moderate to severe or severe renal impairment (creatinine clearance less than 30 ml/min) should not use Naproxen-containing products. These medications are not recommended for individuals with significant renal impairment.
In patients with mild to moderate hepatic impairment, close monitoring is necessary, and a possible dose reduction may be considered based on the Naproxen component of Naprosyn-Plus®. However, Naprosyn-Plus® is not recommended for individuals with severe hepatic impairment, as the Esomeprazole dosage should not exceed 20 mg daily in such cases.
The use of Naprosyn-Plus® has not been established for children under 18 years of age, and therefore, the dosage for this age group has not been determined. It is important to follow the specific dosage instructions provided by your physician or healthcare provider. Swallow the Naprosyn Plus 500/20mg Tablet with a glass of water and do not crush or chew the medication. The correct dose and duration of treatment will be determined by your doctor based on factors such as your age, body weight, and the specific condition being treated.
Naprosyn Plus 500/20mg Tablet can potentially interact with various medications and medical conditions. It is important to be aware of these interactions and consult with your doctor before taking Naprosyn Plus 500/20mg Tablet:
Drug-Drug Interactions: Naprosyn Plus 500/20mg Tablet may interact with anti-inflammatory medicines (such as aspirin, ibuprofen), blood thinners (like warfarin, rivaroxaban), steroids (such as prednisolone), diuretic medicines (like furosemide), medicines used to treat heart problems and high blood pressure (such as propranolol, enalapril, losartan, candesartan), antidepressants (like citalopram), and medicines used to treat rheumatoid arthritis (such as methotrexate). These interactions can affect the effectiveness or increase the risk of side effects of either Naprosyn Plus 500/20mg Tablet or other medications. It is important to inform your doctor about all the medications you are taking to avoid potential interactions.
Drug-Food Interactions: Naprosyn Plus 500/20mg Tablet may interact with alcohol. It is recommended to avoid alcohol intake while taking Naprosyn Plus 500/20mg Tablet as it can increase the risk of stomach bleeding, as well as enhance drowsiness and dizziness associated with the medication.
Drug-Disease Interactions: Individuals with certain medical conditions should consult their doctor before taking Naprosyn Plus 500/20mg Tablet. These conditions include diabetes, stomach ulcer, gastrointestinal bleeding, asthma, kidney or liver problems, heart problems, and autoimmune conditions such as systemic lupus erythematosus (characterized by joint pain, fever, and skin rashes), colitis, or Crohn's disease (conditions causing swelling of the bowel, diarrhea, bowel pain, vomiting, and weight loss). Your doctor will assess the risks and benefits of using Naprosyn Plus 500/20mg Tablet in these situations and may adjust the dosage or recommend alternative treatments if necessary.
It is important to have open communication with your healthcare provider or doctor regarding your medical history, current medications, and any potential interactions or concerns before starting or changing any medication regimen, including Naprosyn Plus 500/20mg Tablet.
Known hypersensitivity: If you have a known hypersensitivity or allergic reaction to any component of Naprosyn-Plus® or substituted benzimidazoles, it is important to avoid using this medication.
History of asthma or allergic reactions: If you have a history of asthma, urticaria (hives), or other allergic-type reactions after taking aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs), Naprosyn-Plus® should be avoided as it may trigger similar reactions.
The peri-operative period in CABG surgery: Naprosyn-Plus® should not be used during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery. This is because it may increase the risk of cardiovascular events and impair the healing process.
Late pregnancy: Naprosyn-Plus® should not be used in the late stages of pregnancy. It is generally recommended to avoid NSAIDs, including Naprosyn-Plus®, in the third trimester of pregnancy due to the potential risks to the fetus and the potential to delay labor.
Naprosyn-Plus® is classified as Pregnancy Category C. It means that there may be potential risks to the fetus, and its use should be avoided in late pregnancy. Naproxen, one of the components of Naprosyn-Plus®, has been associated with the premature closure of the ductus arteriosus in the fetus.
Regarding lactation, Naprosyn-Plus® should not be used by nursing mothers due to the Naproxen component. It is possible for Naproxen to pass into breast milk and may have adverse effects on the nursing infant.
It is important to discuss any concerns or questions about medication use during pregnancy or lactation with your healthcare provider. They can provide personalized advice and suggest alternative treatment options that are safer for you and your baby.
Store in a cool & dry place, and protect from light. Keep out of reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.