Quiet 25mg Tablet

✔️ Quiet 25mg Tablet is used to treat:

• Bipolar Disorder
• Schizophrenia
• Depression (major depressive disorders)
• Autism

✔️ How does Quiet 25mg Tablet work?

Quiet 25mg Tablet works by inhibiting the release of certain chemical substances in the brain which are responsible for causing the symptoms associated with schizophrenia and bipolar disorder.

✔️ Side Effects of Quiet 25mg Tablet

• Dizziness
• Chills
• Confusion
• Blurred vision
• Loss of balance control
• Difficulty or painful urination
• Weight gain
• Constipation
• Headache
• Decreased appetite
• Cough
• Drowsiness
• Increased cholesterol and triglycerides

✔️ Quick Suggestions:

• You have been prescribed Quetiapine for the treatment of schizophrenia and mania.
• It is less likely to cause heart problems and movement disorders than other antipsychotics.
• It may take 4 to 6 weeks to see treatment effects. Keep taking it as prescribed.
• Use caution while driving or doing anything that requires concentration as Quetiapine can cause dizziness and sleepiness.
• To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
• It may increase your weight, blood sugar, and cholesterol. Eat healthy, exercise regularly, and monitor your blood levels regularly.
• Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
• Do not stop taking it without talking to your doctor first as it may cause worsening of symptoms.

✔️ Indication of Quiet 25mg Tablet

Quiet 25mg Tablet contains ‘quetiapine’, which is an antipsychotic drug used in the treatment of schizophrenia (a mental disorder that can result in hallucinations or delusions and also adversely affects a person’s ability to think and behave) and mania. It is also used to treat bipolar disorders. 

✔️ Pharmacology

Quetiapine is an atypical antipsychotic medication that acts as an antagonist at various neurotransmitter receptors in the brain, including serotonin 5-HT1A and 5-HT2, dopamine D1 and D2, histamine H1, and adrenergic a1 and a2 receptors.

Due to its broad receptor-binding profile, Quetiapine is effective in treating symptoms of schizophrenia and bipolar disorder. Its mechanism of action helps to regulate the levels of neurotransmitters in the brain, leading to improved management of these mental health conditions.

✔️ Dosage & Administration of Quiet 25mg Tablet

Schizophrenia (Acute and Chronic Psychoses):

• Initial dose: 50 mg (Day 1), 100 mg (Day 2), 200 mg (Day 3), 300 mg (Day 4).
• Maintenance dose: 300-450 mg/day (range 150 to 750 mg/day) from Day 4 onwards.

Manic Episodes Associated with Bipolar Disorder:

• Initial dose: 100 mg (Day 1), 200 mg (Day 2), 300 mg (Day 3), 400 mg (Day 4).
• Maintenance dose: 200-800 mg/day (range 200 to 800 mg/day) by Day 6.

Depressive Episodes Associated with Bipolar Disorder:

• Initial dose: 50 mg (Day 1), 100 mg (Day 2), 200 mg (Day 3), 300 mg (Day 4).
• Maintenance dose: 300-600 mg/day (range 400 to 600 mg/day) by Day 8.

Maintenance Treatment of Bipolar I Disorder (in combination with mood stabilizers):

• Continue the same dose that was effective during the acute treatment phase (400 to 800 mg/day).

Dosage Instructions:

• Administer Quetiapine twice daily with or without food for acute and manic episodes.
• Administer Quetiapine once daily at bedtime with or without food for depressive episodes.
• Take the medicine at least one hour before meals or before bedtime.
• Swallow the tablet whole with a glass of water. Do not crush or chew it.

Important Notes:

• Follow your doctor's instructions regarding the correct dose and duration of therapy.
• Do not stop taking Quetiapine without your doctor's advice, as it may cause withdrawal symptoms.

Quiet 25mg Tablet is not recommended for use in children younger than 18 years of age as the safety and efficacy data are not clinically established.

✔️ Interaction

Drug-Drug Interactions: Quiet 25mg Tablet may interact with the following medications:

1. Antidepressants: Citalopram, escitalopram, and bupropion.
2. Opioid pain or cough relievers: Codeine, hydrocodone.
3. Drugs for sleep or anxiety: Alprazolam, lorazepam, and zolpidem.
4. Muscle relaxants: Carisoprodol, cyclobenzaprine.
5. Antihistamines: Cetirizine, diphenhydramine.
6. Analgesics: Acetaminophen, hydrocodone, tramadol.

Drug-Food Interactions: Quiet 25mg Tablet may interact with grapefruit and alcohol. Consuming grapefruit or alcohol while on this medication can increase the risk of side effects.

Drug-Disease Interactions: Quiet 25mg Tablet should be used with caution in patients with the following conditions:

1. Heart problems: QT prolongation (heart rhythm problem).
2. Acute alcohol abuse.
3. Central nervous system (CNS) depression.
4. Dementia.
5. Stroke.
6. Seizures.
7. Diabetes.
8. Liver problems.

✔️ Contraindications

• If you are allergic to the active and/or inactive components in the Quiet 25mg Tablet
• If you have narrow-angle glaucoma, taking this medicine might worsen the condition
• If you are on medication for kidney diseases, take this medicine with caution
• If you have a history of urine retention, this medicine might elevate the risk of adverse effects
• If you are on medication for increased blood pressure, take this medicine with caution
• If you take monoamine oxidase inhibitors (MAOs) or have taken them in the last 15 days, you should not use Quiet 25mg Tablet.
• If you are actively suffering from liver disease, use it with caution

✔️ Pregnancy & Lactation

Pregnancy:

• The safety and effectiveness of Quetiapine during human pregnancy have not been established.
• Therefore, Quetiapine should only be used during pregnancy if the potential benefits to the mother outweigh the potential risks to the fetus.
• If Quetiapine is prescribed during pregnancy, the dosage and duration of treatment should be kept as low and as short as possible.

Breastfeeding:

• The extent to which Quetiapine is excreted into human breast milk is unknown.
• Women who are breastfeeding should be advised to avoid breastfeeding while taking Quetiapine.

✔️ Precautions & Warnings

• Inform your doctor about any liver, kidney, or heart problems before taking Quiet 25mg Tablet.
• Notify your doctor if you have diabetes, a history of blood clots, or a history of drug abuse in the past.
• Avoid alcohol and grapefruit juice consumption during treatment, as they may interact with the medication and increase the risk of side effects.
• Consult your doctor if you are pregnant or breastfeeding before taking Quiet 25mg Tablet.
• Use caution in elderly patients with dementia.
• Quiet 25mg Tablet may increase blood sugar levels even if you don't have diabetes, especially in patients with schizophrenia. So, it is recommended to immediately inform your doctor if you have symptoms such as increased thirst, frequent urination, fatigue, or increased appetite.
• If you are having a urine drug screen (an analysis to determine the presence of illegal drugs or drugs that are mostly abused, such as methadone or tricyclic antidepressants in the blood), the test results may show positive when certain test methods are used. A more specific test may be required in such cases.

✔️ Storage Conditions

Keep away from light and moisture in a cool, dry location (below 30° C). Keep out of children's reach.